A5023134201- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Microscopic Colitis
- Mycobacterium research and diagnosis
- Gastrointestinal motility and disorders
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Cytomegalovirus and herpesvirus research
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Antibiotics Pharmacokinetics and Efficacy
- Metabolomics and Mass Spectrometry Studies
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- Actinomycetales infections and treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- Antifungal resistance and susceptibility
- Diet and metabolism studies
- Streptococcal Infections and Treatments
- Herpesvirus Infections and Treatments
- Toxoplasma gondii Research Studies
- Bacteriophages and microbial interactions
- Infectious Diseases and Mycology
Emory University
2017-2025
University of Washington
2024
University of California, San Francisco
2024
San Francisco General Hospital
2024
Christ University
2024
AID Atlanta
2023
Georgia Urology
2022
Grady Health System
2022
University of Oregon
2021
The University of Texas at Austin
2021
Multidrug-resistant organism (MDRO) colonization is a fundamental challenge in antimicrobial resistance. Limited studies have shown that fecal microbiota transplantation (FMT) can reduce MDRO colonization, but its mechanisms are poorly understood. We conducted randomized, controlled trial of FMT for decolonization renal transplant recipients called PREMIX (NCT02922816). Eleven participants were enrolled and randomized 1:1 to or an observation period followed by delayed if stool cultures...
Fecal microbiota transplant (FMT) is recommended for Clostridium difficile infection (CDI) treatment; however, use in solid organ transplantation (SOT) patients has theoretical safety concerns. This multicenter, retrospective study evaluated FMT safety, effectiveness, and risk factors failure SOT patients. Primary cure overall were defined as resolution of diarrhea or negative C stool test after a single subsequent FMT(s) ± anti-CDI antibiotics, respectively. Ninety-four underwent FMT, 78%...
Abstract The intestinal tract is a recognized reservoir of antibiotic-resistant organisms (ARO), and potential target for strategies to reduce ARO colonization. Microbiome therapies such as fecal microbiota transplantation (FMT) have been established an effective treatment recurrent Clostridioides difficile infection may be approach reducing In this article, we review the current published literature on role FMT eradication colonization, benefit limitations use in setting, outline research...
The acquisition of skills to recognize and redress adverse social determinants disease is an important component undergraduate medical education. In this article, the authors justify define "social justice curriculum" then describe school curriculum designed by multidisciplinary Social Justice Vertical Integration Group (SJVIG) at Geisel School Medicine Dartmouth. SJVIG addressed five goals: (1) core competencies in education, (2) identify key topics that a should cover, (3) assess curricula...
Nocardia are uncommon pathogens that disproportionately afflict the immunocompromised host. Epidemiology and outcome data of infections in transplant recipients limited.We performed a retrospective chart review all patients at Duke University Hospital with history solid organ (SOT) or hematopoietic cell (HCT) least one positive culture for between 1996 2013. Our aim was to describe epidemiology outcomes transplanted host.During 18-year study period, 51 (14 HCT 37 SOT recipients) had...
Fecal microbiota transplant (FMT) appears safe and effective for treatment of recurrent Clostridium difficile infection (RCDI). However, durability, long-term clinical outcomes, patient satisfaction after FMT are not well described. Eligible patients who received RCDI at Emory Hospital between 1 July 2012 31 December 2016 were contacted via telephone a follow-up survey. Of 190 eligible patients, 137 (72%) completed the Median time from last to was 22 months. Overall, 82% (113/137) had no...
Abstract Background Microbiome restoration through fecal microbiota transplantation (FMT) is a promising decolonization approach that leads to reduction in multidrug resistant organism (MDRO) colonization and infections. The precise mechanisms by which FMT reduces MDRO are not well elucidated, long-term follow up (LTF) data from patients treated with for lacking. We enrolled participants of recently conducted trial (PREMIX, NCT02922816) LTF study estimate engraftment dynamics donor derived...
With the increase in placement of prosthetic joints and other hardware body has come an associated infections. These infections are particularly difficult to treat due underlying bacteria generating matrices which resist clearance by immune system effectors or antibiotics. matrices, biofilms, have two primary ways being eradicated, either physical removal debridement killing bacteria. The viruses kill bacteria, bacteriophage, readily capable entering into biofilms eradicating therein....
While the inhibitory receptor FcγRIIB has been shown to be upregulated on activated CD8+ T cells in both mice and humans, its effect cell fate during infection not fully elucidated. We identified an increase FcγRIIB-expressing patients with COVID-19 relative healthy controls as well mouse models of viral infection. Despite well-known role Fc receptor, also ligates immunosuppressive cytokine Fgl2, resulting apoptosis. Both chronic LCMV humans resulted a significant plasma Fgl2. Transfer into...
Nocardia is a genus of pathogens that most commonly afflict immunocompromised hosts but may be an emerging infection among persons with bronchiectasis.To examine the epidemiology and clinical presentation adult patients bronchiectasis relative to other patient groups.We examined retrospectively assembled cohort adults at Duke University Hospital in Durham, North Carolina least one positive culture from bodily fluid or tissue specimen for between January 1996 December 2013. Denominator data...
Abstract Advances in genomics have revealed many of the genetic underpinnings human disease, but exposomics methods are currently inadequate to obtain a similar level understanding environmental contributions disease. Exposomics limited by low abundance xenobiotic metabolites and lack authentic standards, which precludes identification using solely mass spectrometry-based criteria. Here, we develop validate method for enzymatic generation use with high-resolution spectrometry (HRMS) chemical...
Toxoplasma gondii can cause severe opportunistic infection in immunocompromised individuals, but diagnosis is often delayed. We conducted a retrospective review of solid organ transplant (SOT) and hematopoietic stem cell (HSCT) recipients with toxoplasmosis between 2002 2018 at two large US academic centers. Patients were identified by ICD-9 or ICD-10 codes, positive polymerase chain reaction test result, pathologic diagnosis. Data collected regarding type, time from to diagnosis, clinical...
Abstract Food and Drug Administration approval of the first microbiome therapies represents a true expansion treatment paradigm for Clostridioides difficile but raises new questions about future role fecal microbiota transplantation. The authors outline advances in therapeutic development that have addressed transplantation’s (FMT's) inherent limitations safety scalability. also suggest as continues other indications, FMT will likely remain necessary model human dynamics translational research.
Abstract Background Fecal microbiota transplantation (FMT) is recommended for the treatment of recurrent Clostridioides difficile infection (rCDI). In current study, we evaluated rates rCDI and subsequent FMT in a large metropolitan area. We compared demographic clinical differences recipients nonrecipients quantified outcomes based on modality. Methods A retrospective community-wide cohort study was conducted using surveillance data from Georgia Emerging Infections Program, Discharge Data...