A5015366089- Vector-borne infectious diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Dermatological diseases and infestations
- Zoonotic diseases and public health
- Cytomegalovirus and herpesvirus research
- COVID-19 epidemiological studies
- Vector-Borne Animal Diseases
- Herpesvirus Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Assisted Reproductive Technology and Twin Pregnancy
- Health disparities and outcomes
- Parvovirus B19 Infection Studies
- Malaria Research and Control
- Bartonella species infections research
- Food Security and Health in Diverse Populations
- Mycobacterium research and diagnosis
- Neonatal and Maternal Infections
- Psychosomatic Disorders and Their Treatments
- Escherichia coli research studies
- Travel-related health issues
- Maternal and Perinatal Health Interventions
- Reproductive Health and Technologies
- Urinary Tract Infections Management
- COVID-19 and healthcare impacts
Duke University
2015-2024
Duke Institute for Health Innovation
2017-2024
Duke Medical Center
2010-2021
Princeton University
2021
Duke University Hospital
2017-2020
New York University
2020
Case Western Reserve University
2020
Johns Hopkins University
2020
Yale University
2020
VA Northeast Ohio Healthcare System
2020
Abstract This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing Infectious Diseases Society America (IDSA), American Academy Neurology (AAN), College Rheumatology (ACR). The scope this includes prevention disease, diagnosis presenting as erythema migrans, complicated neurologic, cardiac, rheumatologic manifestations, Eurasian manifestations coinfection with other tick-borne...
The conventional 2-tiered serologic testing protocol for Lyme disease (LD), an enzyme immunoassay (EIA) followed by immunoglobulin M and G Western blots, performs well in late-stage LD but is insensitive patients with erythema migrans (EM), the most common manifestation of illness. blots are also complex, difficult to interpret, relatively expensive. In effort improve test performance simplify early LD, we evaluated several modified (MTTT) protocols, which use 2 assays designed as first-tier...
Abstract The purpose of this guideline is to provide evidence-based guidance for the most effective strategies diagnosis and management babesiosis. treatment co-infection with babesiosis Lyme disease will be addressed in a separate Infectious Diseases Society America (IDSA), American Academy Neurology (AAN), College Rheumatology (ACR) [1]. Recommendations human granulocytic anaplasmosis can found recent rickettsial developed by Centers Disease Control Prevention [2]. target audience includes...
Studies elucidating determinants of residential neighborhood-level health inequities are needed.
In April 2008, the Infectious Diseases Society of America (IDSA) entered into an agreement with Connecticut Attorney General Richard Blumenthal to voluntarily undertake a special review its 2006 Lyme disease guidelines. This ended General's investigation process by which guidelines were developed. The IDSA agreed convene independent panel conduct one-time Review Panel members, vetted ombudsman for potential conflicts interest, reviewed entirety guidelines, particular attention...
Bartonella vinsonii subsp. berkhoffii is an important, emerging, intravascular bacterial pathogen that has been recently isolated from immunocompetent patients with endocarditis, arthritis, neurological disease and vasoproliferative neoplasia. Vector transmission suspected among dogs wild canines, which are the primary reservoir hosts. This investigation was initiated to determine if pets family members were infected one or more species. PCR enrichment blood culture in alpha Proteobacteria...
Abstract The purpose of this guideline is to provide evidence-based guidance for the most effective strategies diagnosis and management babesiosis. treatment co-infection with babesiosis Lyme disease will be addressed in a separate Infectious Diseases Society America (IDSA), American Academy Neurology (AAN), College Rheumatology (ACR) [1]. Recommendations human granulocytic anaplasmosis can found recent rickettsial developed by Centers Disease Control Prevention [2]. target audience includes...
This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing Infectious Diseases Society North American (IDSA), Academy Neurology (AAN), College Rheumatology (ACR). The scope this includes prevention disease, diagnosis presenting as erythema migrans, complicated neurologic, cardiac, rheumatologic manifestations, Eurasian manifestations coinfection with other tick-borne pathogens. does not...
The diagnosis of chronic Lyme disease has been embroiled in controversy for many years. This is exacerbated by the lack a clinical or microbiologic definition, and commonality symptoms general population. An accumulating body evidence suggests that appropriate only minority patients whom it suspected. In prospective studies disease, very few go on to have syndrome dominated subjective complaints. There no systematic Borrelia burgdorferi, etiology can be identified with following treated...
Background. The majority of Lyme disease cases in the United States are acquired on east coast between northern Virginia and New England. In recent years geographic extent has been expanding, raising prospect becoming endemic southeast. Methods. We collected confirmed probable from 2000 through 2014 Department Health North Carolina Public entered them a information system. performed spatial spatiotemporal cluster analyses to characterize expansion. Results. There was marked increase...
Bartonella species are important emerging pathogens in human and veterinary medicine. In the context of their daily activities, professionals have frequent animal contact arthropod exposures. Detection spp. using traditional culture methods has been limited by poor sensitivity, making it difficult to determine prevalence infection this population. We developed a detection method combining enrichment molecular amplification, which increases testing sensitivity.We performed cross-sectional...
Approximately 1 to 2 of every 1000 American newborns has hearing loss identified by newborn screening. This study was designed determine if infant is more common in socioeconomically disadvantaged communities.In this retrospective study, we analyzed electronic medical record data using geostatistical models.Infants were residents Durham County, North Carolina, born hospitals the Duke University Health System. county includes city and surrounding suburban rural communities.Subjects...
This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing Infectious Diseases Society America (IDSA), American Academy Neurology (AAN), College Rheumatology (ACR). The scope this includes prevention disease, diagnosis presenting as erythema migrans, complicated neurologic, cardiac, rheumatologic manifestations, Eurasian manifestations coinfection with other tick-borne pathogens. does...
Although Lyme disease is the most common vector-borne infection in United States, diagnostic accuracy within community settings not well characterized.A retrospective observational cohort study of patients referred to an academic center with a presumed diagnosis or concern for between 2000 and 2013 was performed analyze diagnoses treatments. Characteristics those misdiagnosed as having were compared.Of 1261 patients, 911 (72.2%) did have disease, 184 (14.6%) had active recent 150 (11.9%)...
Abstract Only indirect or circumstantial evidence has been published to support transmission of Rickettsia rickettsii by Amblyomma americanum (lone star) ticks in North America. This study provides molecular that A. can function, although most likely infrequently, as vectors Rocky Mountain spotted fever for humans.
Background. Lyme disease is diagnosed by 2-tiered serologic testing in patients with a compatible clinical illness, but the significance of positive test results low-prevalence regions has not been investigated. Methods. We reviewed medical records who tested for standardized between 2005 and 2010 at single hospital system region little endemic disease. Based on findings, we calculated predictive value serology. Next, outcome select syndromes disseminated (arthritis, cranial neuropathy, or...
Cytomegalovirus (CMV) is the most common infectious cause of fetal malformations and childhood hearing loss. CMV more among socially disadvantaged groups, it clusters geographically in poor communities. We conducted a geospatial analysis chronic primary infection pregnant women around Durham, NC. performed subjects from an ongoing study using geographic information systems spatial statistics. Subjects were categorized on basis results their immunoglobulin G avidity testing as seronegative,...
Nocardia is a genus of pathogens that most commonly afflict immunocompromised hosts but may be an emerging infection among persons with bronchiectasis.To examine the epidemiology and clinical presentation adult patients bronchiectasis relative to other patient groups.We examined retrospectively assembled cohort adults at Duke University Hospital in Durham, North Carolina least one positive culture from bodily fluid or tissue specimen for between January 1996 December 2013. Denominator data...