A5019692561- Vector-borne infectious diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Dermatological diseases and infestations
- Insect and Pesticide Research
- Yersinia bacterium, plague, ectoparasites research
- Toxin Mechanisms and Immunotoxins
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Zoonotic diseases and public health
- Viral gastroenteritis research and epidemiology
- Insect symbiosis and bacterial influences
- Bartonella species infections research
- Inflammasome and immune disorders
- Viral Infections and Outbreaks Research
- Emergency and Acute Care Studies
- Immunodeficiency and Autoimmune Disorders
- Animal Virus Infections Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Drug-Induced Adverse Reactions
- Malaria Research and Control
- Viral Infections and Immunology Research
- Respiratory and Cough-Related Research
- SARS-CoV-2 and COVID-19 Research
Ljubljana University Medical Centre
2016-2025
University Medical Center
1992-2025
University of Ljubljana
1999-2025
Evelina London Children's Healthcare
2023
Guy's and St Thomas' NHS Foundation Trust
2023
University of California, Irvine
2022
New York State Department of Health
2022
Massachusetts Department of Public Health
2022
Duke University
2020
New York University
2020
Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as ehrlichiosis), and babesiosis were prepared by an expert panel Infectious Diseases Society America. These updated replace previous treatment published in 2000 (Clin Infect Dis 2000; 31[Suppl 1]:1-14). The are intended use health care providers who either have these infections or may be at risk them. For each Ixodes tickborne infections, information is provided about...
Abstract This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing Infectious Diseases Society America (IDSA), American Academy Neurology (AAN), College Rheumatology (ACR). The scope this includes prevention disease, diagnosis presenting as erythema migrans, complicated neurologic, cardiac, rheumatologic manifestations, Eurasian manifestations coinfection with other tick-borne...
Human granulocytic ehrlichiosis (HGE) was recently described in North America. It is caused by an Ehrlichia species closely related to phagocytophila and equi, recognized infect mostly ruminants horses, respectively. The vector America the tick Ixodes scapularis, which also of Lyme disease agent, Borrelia burgdorferi. Previous serologic studies patients with a diagnosis borreliosis indicate that HGE may exist Europe. We report first documented case established seroconversion E. equi agent...
Lyme borrelosis is a multi-systemic disease caused byBorrelia burgdorferisensu lato. A complete presentation of the an extremely unusual oberservation, in which skin lesion follows tick bite, itself followed by heart and nervous system involvement, later on arthritis; late involvement eye, system, joints may also occur. Information relative frequency individual clinical manifestations borreliosis limited; however, most frequently involved represent clues for diagnosis. The only sign that...
Background. Information on the course and outcome of early European Lyme neuroborreliosis is limited. Methods. The study comprised 77 patients (38 males, 39 females; median age, 58 years) diagnosed with painful meningoradiculitis (Bannwarth syndrome) who were followed up for 1 year at a single center. Results. Duration neurological symptoms before diagnosis was 30 (interquartile range, 14–50) days. most frequent symptoms/signs radicular pain (100%), sleep disturbances (75.3%), erythema...
Tick-borne encephalitis (TBE) developed in 3 persons Slovenia who drank raw milk; a fourth person, had been vaccinated against TBE, remained healthy. TBE virus RNA was detected serum and milk of the source goat. Persons TBE-endemic areas should be encouraged to drink only boiled/pasteurized vaccinated.
Background. The causes of post-Lyme disease symptoms are unclear. Herein, we investigated whether specific immune responses were correlated with such symptoms. Methods. levels 23 cytokines and chemokines, representative innate adaptive responses, assessed in sera from 86 antibiotic-treated European patients erythema migrans, 45 41 without symptoms, who evaluated prior to treatment 2, 6, 12 months thereafter. Results. At study entry, significant differences between groups observed for the...
Borrelia burgdorferi sensu stricto isolates from patients with erythema migrans in Europe and the United States were compared by genotype, clinical features of infection, inflammatory potential. Analysis outer surface protein C multilocus sequence typing showed that strains these 2 regions represent distinct genotypes. Clinical infection B. Slovenia similar to afzelii or garinii, other spp. cause disease Europe, whereas associated more severe disease. Moreover, induced peripheral blood...
Background The prescription rate of antibiotics is high for febrile children visiting the emergency department (ED), contributing to antimicrobial resistance. Large studies at European EDs covering diversity in antibiotic and broad-spectrum prescriptions all are lacking. A better understanding variability its relation with viral or bacterial disease essential development implementation interventions optimise use. As part PERFORM (Personalised Risk assessment Febrile illness Optimise...
Lyme disease is the most common vector-borne in North America and Europe. The clinical manifestations of vary based on genospecies infecting Borrelia burgdorferi spirochete, but microbial genetic elements underlying these associations are not known. Here, we report whole genome sequence (WGS) analysis 299 B . ( Bb ) isolates derived from patients Eastern Midwestern US Central We develop a WGS-based classification isolates, confirm extend findings previous single- multi-locus typing systems,...
Background: The clinical manifestations of Lyme borreliosis in North America and Europe seem to differ, but a systematic comparison has never been done. Objective: To compare European U.S. patients with culture-confirmed erythema migrans. Design: Prospective, cohort study. Setting: University medical centers Westchester County, New York, Ljubljana, Slovenia. Patients: 119 Borrelia burgdorferi sensu stricto infection 85 Slovenian B. afzelii infection. Measurements: Interview, physical...
Background. The most common cause of Lyme neuroborreliosis in Europe is Borrelia garinii, followed by afzelii. However, no series describing patients with culture-confirmed cases have been published, and comparison findings for B. garinii afzelii isolated from cerebrospinal fluid (CSF) has reported. Methods. All adult identified at a single medical center during 10-year period who had borreliae CSF typed as or (using large DNA fragment patterns obtained the MluI restriction endonuclease...
Borrelial infection may manifest with a wide range of clinical signs, and in many cases, microbiological findings are essential for proper diagnosis. This study included 48 patients working diagnosis Lyme neuroborreliosis, 45 suspected control group comprising 42 tick-borne encephalitis 21 neurosurgical patients. The aim the was to analyze compare two PCR methods Borrelia burgdorferi sensu lato culture results by examination prospectively collected cerebrospinal fluid (CSF) blood specimens...