A5002417145- Vector-borne infectious diseases
- Viral Infections and Vectors
- Dermatological diseases and infestations
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Vector-Borne Animal Diseases
- Antimicrobial Resistance in Staphylococcus
- Data-Driven Disease Surveillance
- Insect and Pesticide Research
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Use and Resistance
- Ocular Infections and Treatments
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- Neonatal and Maternal Infections
- Research on Leishmaniasis Studies
- Antifungal resistance and susceptibility
- Toxin Mechanisms and Immunotoxins
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial biofilms and quorum sensing
Westchester Medical Center
1996-2024
New York Medical College
2002-2024
New York University
2013-2023
NYU Langone Health
2012-2023
City University of New York
2022
Long Island University
2019-2020
Johns Hopkins University
1996-2020
Yale University
2013-2020
Duke University
2020
Case Western Reserve University
2020
It is unclear whether antimicrobial treatment after an Ixodes scapularis tick bite will prevent Lyme disease.
Abstract This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing Infectious Diseases Society America (IDSA), American Academy Neurology (AAN), College Rheumatology (ACR). The scope this includes prevention disease, diagnosis presenting as erythema migrans, complicated neurologic, cardiac, rheumatologic manifestations, Eurasian manifestations coinfection with other tick-borne...
The recent emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has posed formidable challenges for clinical laboratories seeking reliable laboratory diagnostic confirmation. swift advance crisis in United States led to Emergency Use Authorization (EUA) facilitating availability molecular assays without more rigorous examination which tests are normally subjected prior FDA approval. Our currently uses two real-time reverse transcription-PCR (RT-PCR)...
Infection with the agent of human granulocytic ehrlichiosis occurs in areas which Borrelia burgdorferi and Babesia microti are endemic.1–4 The most likely vector is deer tick, Ixodes scapularis, also Lyme disease babesiosis.3,4 Coinfection humans both B. can be anticipated because ixodes ticks infected two organisms have been identified several locales.3–5 diagnosis simultaneous infection important natural history . . .
Background: Human granulocytic ehrlichiosis (HGE) is a newly described illness with few reports in the literature. Objective: To describe clinical and laboratory features of HGE. Design: Case series. Setting: Tertiary care facility New York State. Patients: 18 adult patients Measurements: Epidemiologic, clinical, features; treatment; outcome Results: Patients presented such symptoms as fever (94%) myalgia or arthralgia (78%). Thirteen (71%) recalled being bitten by tick before onset...
We describe the rapid and ongoing emergence across multiple US cities of a new multidrug-resistant Escherichia coli clone—sequence type (ST) 1193—resistant to fluoroquinolones (100%), trimethoprim-sulfamethoxazole (55%), tetracycline (53%). ST1193 is associated with younger adults (age <40 years) currently comprises quarter fluoroquinolone-resistant clinical E. urine isolates.
Effective public response to a pandemic relies upon accurate measurement of the extent and dynamics an outbreak. Viral genome sequencing has emerged as powerful approach link seemingly unrelated cases, large-scale surveillance can inform on critical epidemiological parameters. Here, we report analysis 864 SARS-CoV-2 sequences from cases in New York City metropolitan area during COVID-19 outbreak spring 2020. The majority had no recent travel history or known exposure, genetically linked were...
Recently, a number of refinements in diagnostic modalities for detection Borrelia burgdorferi infection have been developed. These include large-volume blood cultures, quantitative polymerase chain reaction (PCR) techniques, and 2-stage serologic testing. In the present study, we compared 6 47 adult patients who had clinical diagnosis erythema migrans. Quantitative PCR on skin biopsy-derived material was most sensitive method (80.9%), followed by testing convalescent-phase samples (66.0%),...
Standard 2-tiered immunoglobulin G (IgG) testing has performed well in late Lyme disease (LD), but IgM early the illness been problematic. IgG VlsE antibody testing, by itself, improves sensitivity, may lower specificity. We studied whether elements of 2 approaches could be combined to produce a second-tier blot that performs throughout infection.Separate serum sets from LD patients and control subjects were tested independently at medical centers using whole-cell enzyme immunoassays...
Babesiosis is usually acquired from a tick bite or through blood transfusion. We report case of babesiosis in an infant for whom vertical transmission was suggested by evidence Babesia spp. antibodies the heel-stick sample and confirmed detection DNA placenta tissue.
Background. Lyme disease is transmitted by the bite of Ixodes scapularis tick, which can also transmit Anaplasma phagocytophilum, cause human granulocytic anaplasmosis (HGA). Conflicting data exist on frequency coinfection and whether Lyme-HGA coinfected patients have more symptoms than with alone.
There have been multiple descriptions of seizures during the acute infectious period in patients with COVID-19. However, there no reports status epilepticus after recovery from COVID-19 infection. Herein, we discuss a patient refractory 6 weeks initial infection Extensive workup demonstrated elevated inflammatory markers, recurrence positive nasopharyngeal SARS-CoV-2 polymerase chain reaction, and hippocampal atrophy. Postinfectious inflammation may triggered manner similar to multisystemic...
The extended-spectrum-β-lactamase (ESBL)- and Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae represent serious urgent threats to public health. In a retrospective study of multidrug-resistant K. pneumoniae, we identified three clinical isolates, CN1, CR14, NY9, carrying both blaCTX-M blaKPC genes. complete genomes these isolates were de novo assembled by using short- long-read whole-genome sequencing. CR14 carried on two different plasmids. contrast, CN1 had one copy...
This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing Infectious Diseases Society North American (IDSA), Academy Neurology (AAN), College Rheumatology (ACR). The scope this includes prevention disease, diagnosis presenting as erythema migrans, complicated neurologic, cardiac, rheumatologic manifestations, Eurasian manifestations coinfection with other tick-borne pathogens. does not...
Understanding antibody responses to SARS-CoV-2 is indispensable for the development of containment measures overcome current COVID-19 pandemic. Recent studies showed that serum from convalescent patients can display variable neutralization capacities. Still, it remains unclear whether there are specific signatures be used predict neutralization. Here, we performed a detailed analysis sera cohort 101 recovered healthcare workers and addressed their response by ELISA against Spike receptor...
OBJECTIVE: Current data suggest that the transplacental passage of immunoglobulin (Ig) G antibodies to SARS-CoV-2 virus occurs following natural infection,1Flannery DD Gouma S Dhudasia MB et al.Assessment maternal and neonatal cord blood placental transfer ratios.JAMA Pediatr. 2021; 175: 594-600Crossref PubMed Scopus (174) Google Scholar there is emerging evidence antibody may occur COVID-19 messenger RNA (mRNA) vaccination.2Mithal LB Otero Shanes ED Goldstein JA Miller ES. Cord coronavirus...
The agent of human granulocytic ehrlichiosis (HGE), Ehrlichia phagocytophila, and equi are very similar. HGE is variable severity. Genetic antigenic differences among 3 isolates (Webster, Spooner, NY-8) 1 horse isolate (MRK) were evaluated. 16S rRNA gene sequences identical in all isolates. By use 5 homologous antisera from these humans an additional heterologous reactions, the immunodominant antigens each noted to differ molecular size: 43 kDa Webster (Wisconsin) isolate, 46 Spooner 42 45...
Human granulocytic ehrlichiosis was first described in the United States, northern Midwest, 1994.1 is caused by an organism, still referred to as agent of human ehrlichiosis, that similar two animal pathogens, Ehrlichia phagocytophila and E. equi. 2–4 Transmission occurs through bites ixodes ticks, which are arthropod vectors for Borrelia burgdorferi Babesia microti. 5,6 acute, febrile, nonspecific illness may be severe enough cause hospitalization even death, particularly elderly.1,7,8 We...
ABSTRACT We determined the frequencies of antibodies to Anaplasma phagocytophila , agent human granulocytic ehrlichiosis (HGE), in different groups adults and children from Westchester County, New York. The included 159 adult blood donors 215 who were seronegative for Borrelia burgdorferi antibodies, 118 patients 57 seropositive B. 42 with culture-confirmed erythema migrans. Eighteen (11.3%) 11 (5.1%) -seronegative found have A. by indirect immunofluorescent-antibody assay (IFA). Nine...
As the 100th anniversary of Flexner report nears, medical student education is being reviewed at many levels. One area concern, expressed in recent reports from some national health care organizations, adequacy training discipline laboratory medicine (also termed clinical pathology). The Academy Clinical Laboratory Physicians and Scientists appointed an ad hoc committee to review this topic develop a suggested curriculum, which was subsequently forwarded entire membership for review....
Since the year 2000, linezolid has been used in United States to treat infections caused by antimicrobial-resistant Gram-positive cocci. At present, linezolid-resistant (Linr) Staphylococcus aureus and epidermidis strains are rare diversity of their genetic backgrounds is unknown. We performed sequence-based strain typing resistance gene characterization 46 Linr isolates that were collected from local national sources between years 2004 2007. Resistance was found occur at least three clonal...