A5027850301- Metabolomics and Mass Spectrometry Studies
- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Health, Environment, Cognitive Aging
- Fungal and yeast genetics research
- Biofuel production and bioconversion
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Fungal Biology and Applications
- Per- and polyfluoroalkyl substances research
- Carcinogens and Genotoxicity Assessment
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Diet and metabolism studies
- Advanced biosensing and bioanalysis techniques
- Trace Elements in Health
- Advanced Chemical Sensor Technologies
- Selenium in Biological Systems
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Radioactivity and Radon Measurements
- RNA Interference and Gene Delivery
- Child Nutrition and Water Access
Emory University
2016-2025
Peking University
2001-2024
University of Atlanta
2024
Zhejiang University
2023
State Key Laboratory of Digital Medical Engineering
2021-2022
Southeast University
2021-2022
First Affiliated Hospital of Xinjiang Medical University
2022
Xinjiang Medical University
2022
Pulmonary and Allergy Associates
2020
Shandong University of Science and Technology
2018-2019
Influenza is a significant health concern worldwide. Viral infection induces local and systemic activation of the immune system causing attendant changes in metabolism. High-resolution metabolomics (HRM) uses advanced mass spectrometry computational methods to measure thousands metabolites inclusive most metabolic pathways. We used HRM identify pathways clusters association related inflammatory cytokines lungs mice with H1N1 influenza virus infection. Infected showed progressive weight loss,...
Omics-based technologies have enabled comprehensive characterization of our exposure to environmental chemicals (chemical exposome) as well assessment the corresponding biological responses at molecular level (eg, metabolome, lipidome, proteome, and genome). By systematically measuring personal exposures linking these stimuli perturbations, researchers can determine specific chemical concern, identify mechanisms biomarkers toxicity, design interventions reduce exposures. However, further...
Abstract Complementing the genome with an understanding of human exposome is important challenge for contemporary science and technology. Tens thousands chemicals are used in commerce, yet cost targeted environmental chemical analysis limits surveillance to a few hundred known hazards. To overcome limitations which prevent scaling chemicals, we develop single-step express liquid extraction gas chromatography high-resolution mass spectrometry operationalize exposome. We show that workflow...
Manganese (Mn) is an abundant redox-active metal with well-characterized mitochondrial accumulation and neurotoxicity due to excessive exposures. Mn also essential co-factor for the antioxidant protein, superoxide dismutase-2 (SOD2), range adequate intake established by Institute of Medicine Food Nutrition Board 20% interim guidance value toxicity Agency Toxic Substances Disease Registry, leaving little margin safety. To study toxic mechanisms over this critical dose range, we treated human...
Acylcarnitines transport fatty acids into mitochondria and are essential for β-oxidation energy metabolism. Decreased mitochondrial activity results in increased plasma acylcarnitines, acylcarnitines activate proinflammatory signaling associate with age-related disease. Changes associated healthy aging, however, not well characterized. In the present study, we examined associations of age (range: 20-90) 163 healthy, non-diseased individuals from predictive medicine research cohort...
Since the early 1990s, there has been a dramatic rise in gastrointestinal cancers diagnosed patients under age 50 for reasons that remain poorly understood. The most significant change increase incidence rates of early-onset colorectal cancer, especially left-sided colon and rectal cancers. Increases gastric, pancreatic, other cancer diagnoses have further contributed to this trend. We formed multidisciplinary Think Tank develop strategic, coordinated approach studying This area research is...
Exposure to per- and polyfluoroalkyl substances (PFAS), a prevalent class of persistent pollutants, may increase the risk type 2 diabetes.We examined associations between PFAS exposure glucose metabolism in youth.Overweight/obese adolescents from Study Latino Adolescents at Risk Type Diabetes (SOLAR; n=310) participated annual visits for an average 3.3±2.9y. Generalizability findings were tested young adults Southern California Children's Health (CHS; n=135) who clinical visit with similar...
Antagonistic interaction refers to opposing beneficial and adverse signaling by a single agent. Understanding is important because pathologic outcomes can result from causative agents or the failure of mechanisms. To test for responses at systems level, we used transcriptome–metabolome-wide association study (TMWAS) with rationale that metabolite changes provide phenotypic readout gene expression, expression provides metabolites. We incorporated measures mitochondrial oxidative stress (mtOx)...
Cadmium (Cd) is a toxic environmental metal that interacts with selenium (Se) and contributes to many lung diseases. Humans have widespread exposures Cd through diet cigarette smoking, studies in rodent models show Se can protect against toxicities. We sought identify whether an antagonistic relationship existed between burdens determine this may associate metabolic variation within human lungs. performed metabolomics of 31 lungs, including 25 end-stage disease due idiopathic pulmonary...
Recent studies have linked exposure to road traffic noise or air pollution with incident type 2 diabetes (T2D), but investigation on their co-exposure was limited and underlying mechanisms remain unclear. We hypothesized that long-term increases the risk of T2D via development metabolic syndrome (MetS).This prospective study included 390,834 participants in UK Biobank. Cumulative index (CRI), health-based weighted levels multiple exposures, applied characterize 24-hour (Lden), particulate...
Despite the continued presence of PCBs in indoor and ambient air, few studies have investigated inhalation route exposure. While dietary exposure has declined, semivolatile, lower-chlorinated risen importance. We measured uptake, distribution, time course elimination inhaled PCB congeners to characterize pulmonary after short-term Vapor-phase were generated from Aroclor 1242 a nose-only system characterized for congener levels profiles. Rats exposed via acutely (2.4 mg/m3 2 h) or subacutely...
Although inhalation of atmospheric polychlorinated biphenyls (PCBs) is the most universal exposure route and has become a substantial concern in urban areas, research lacking to determine body burden inhaled PCBs consequent health effects. To reflect Chicago airshed environment mimic PCB profile air, we generated vapors from air mixture (CAM). Sprague-Dawley rats were exposed CAM vapor for 1.6 h/day via nose-only 4 weeks, 520 ± 10 μg/m(3). Congener-specific quantification tissue samples was...