A5034639674- Metabolomics and Mass Spectrometry Studies
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Advanced Chemical Sensor Technologies
- Vanadium and Halogenation Chemistry
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gut microbiota and health
- Sperm and Testicular Function
- Heme Oxygenase-1 and Carbon Monoxide
- Reproductive Biology and Fertility
- Selenium in Biological Systems
- Diet and metabolism studies
- Sulfur Compounds in Biology
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Pesticide and Herbicide Environmental Studies
- Weed Control and Herbicide Applications
- Air Quality and Health Impacts
- Diet, Metabolism, and Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health, Environment, Cognitive Aging
- Phytoestrogen effects and research
- Superconductivity in MgB2 and Alloys
Emory University
2020-2025
University of Atlanta
2024
University of Georgia
2018-2022
Pulmonary and Allergy Associates
2020
The adoption of genetically engineered (GE) crops in agriculture has increased dramatically over the last few decades. Among transgenic plants, those tolerant to herbicide glyphosate are among most common. Weed resistance glyphosate-based herbicides (GBHs) been on rise, leading applications. This, turn, led residues feed. Although considered be generally safe animal health, recent studies have shown that GBHs potential cause adverse effects reproduction, including disruption key regulatory...
Acylcarnitines transport fatty acids into mitochondria and are essential for β-oxidation energy metabolism. Decreased mitochondrial activity results in increased plasma acylcarnitines, acylcarnitines activate proinflammatory signaling associate with age-related disease. Changes associated healthy aging, however, not well characterized. In the present study, we examined associations of age (range: 20-90) 163 healthy, non-diseased individuals from predictive medicine research cohort...
Cadmium (Cd) is a toxic environmental metal that interacts with selenium (Se) and contributes to many lung diseases. Humans have widespread exposures Cd through diet cigarette smoking, studies in rodent models show Se can protect against toxicities. We sought identify whether an antagonistic relationship existed between burdens determine this may associate metabolic variation within human lungs. performed metabolomics of 31 lungs, including 25 end-stage disease due idiopathic pulmonary...
Abstract Early-life respiratory syncytial virus (RSV) infection (eRSV) is a major cause of severe illness in children and increases the risk asthma lung dysfunction later life. Cadmium (Cd), toxic environmental metal, exacerbates these risks when combined with eRSV. Our previous research demonstrated that eRSV reprograms metabolism amplifies Cd toxicity, driving inflammation metabolic disruption through protein palmitoylation. Recent studies showed inhibiting mTORC1 rapamycin (Rapa)...
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as NAFLD, is the most common in children. Liver biopsy remains gold standard for diagnosis, although more efficient screening methods are needed. We previously developed a novel NAFLD panel youth using machine learning applied to high-resolution metabolomics and clinical phenotype data. Our objective was validate this separate cohort, which consisted of combined cross-sectional sample 161 children with stored...
We used relevant dietary and environmental doses of Vanadium pentoxide (V +5 ) to examine its metabolic impact in vitro vivo. Using liquid chromatography-high-resolution mass spectrometry (LC-HRMS), we found significant perturbations, with similar dose-dependent patterns observed human lung fibroblasts male mouse lungs. Alterations lipid metabolism included inflammatory signaling, elevated hydroxyproline levels, excessive collagen deposition were present V -treated Our findings suggest that...
Electronic nicotine delivery system (ENDS) use has become a popular, generally regarded as safe, alternative to tobacco use. The e-liquids used for ENDS vapor generation commonly contain flavoring agents, such maltol, which have been subjected little investigation of their effects on lung health from usage. In the present study, we examined impacts firsthand (3.9 mM) and secondhand µM) exposure levels maltol-flavored vapors metabolism. Human bronchial epithelial cells were exposed using...
Abstract Respiratory syncytial virus (RSV) infection causes serious pulmonary disease and death in high-risk infants elderly. Cadmium (Cd) is a toxic environmental metal contaminant constantly exposed to humans. Limited information available on Cd toxicity after early-life respiratory infection. In this study, we examined the effects of low-dose exposure following RSV lung metabolism inflammation using mouse fibroblast culture models. C57BL/6J mice at 8 days old were 2 times with 4-week...
Abstract Early-life respiratory syncytial virus (RSV) infection (eRSV) is one of the leading causes serious pulmonary disease in children. eRSV associated with higher risk developing asthma and compromised lung function later life. Cadmium (Cd) a toxic metal, widely present environment food. We recently showed that reprograms metabolism potentiates Cd toxicity lung, our transcriptome-metabolome-wide study strong associations between S-palmitoyl transferase expression Cd-stimulated...
Electronic cigarettes (e-cig) are an increasingly popular alternative to traditional smoking but have been in use for too short of a period time fully understand health risks. Furthermore, associated risks difficult evaluate because large range flavoring agents and their combinations with e-cig. Many generally regarded as safe limited studies effects on lung. Vanillin, aromatic aldehyde, is one the most commonly used Vanillin electrophilic can be redox active, chemical properties expected...
Little is known about lipid changes that occur in the setting of metabolic-dysfunction-associated steatotic liver disease (MASLD) regression. We previously reported improvements hepatic steatosis, de novo lipogenesis (DNL), and metabolomic profiles associated with oxidative stress, inflammation, selected metabolism 40 adolescent boys (11–16 y) steatosis ≥5% (98% meeting definition MASLD). Participants were randomized to a low-free-sugar diet (LFSD) (n = 20) or usual for 8 weeks. Here, we...
Sperm mobility is a major determinant of sperm quality in the domesticated chicken (Gallus domesticus) and therefore an area interest for improving fertility. Sperm-associated antigen 6 (SPAG6) important flagellar protein implicated to be necessary function but negatively associated with rooster This study was aimed characterize expression SPAG6 investigate its utility as biomarker mobility. By western analysis, relative abundances were compared between testicular, epididymal, vasal tissues...
Primary sclerosing cholangitis (PSC) is a complex bile duct disorder. Its etiology incompletely understood, but environmental chemicals likely contribute to risk. Patients with PSC have an altered metabolome, which may be influenced by chemicals. This novel study utilized state-of-the-art high-resolution mass spectrometry (HRMS) samples provide the first characterization of and metabolomics (collectively, exposome) in patients located United States America (USA) (n = 24) Norway 30). First,...
This report identifies, for the first time, a phytochelatin compound, 2 [γ-E-C-γ-E-C-G], and related metabolites in human urine. Phytochelatins are metal-binding peptides produced by plants. They present nearly all diets, due to their ubiquity The urinary concentration of among 143 adults was low micromolar range, its had differential correlations with selenium toxic metals. Activities ingested phytochelatins largely undescribed. Observed metal interactions were investigated further cell...
Abstract A prospective metabolome-wide association study revealed widespread amino acid limitation in late pregnancy is associated with early onset breast cancer. Archival third trimester serum samples from 172 women who subsequently were diagnosed cancer within 38 years after compared to 351 without No individual metabolite differed false discovery rate adjustment, indicating that metabolites are unlikely be useful for classification or prediction. Despite this, pathway enrichment analysis...
In sexual reproduction, a male gamete or sperm cell fuses with female to bring about fertilization. However, large number of cells fertilizing ability are required interact ensure As such, the individual is critical for successful reproduction. Density gradient centrifugation has been utilized several decades as reproducible, fast, efficient, effective and extremely adaptable method collect only high-quality be used in assisted reproductive technology. The protocols we described herein focus...