A5036599739- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Glycosylation and Glycoproteins Research
- Evolution and Genetic Dynamics
- Lung Cancer Research Studies
- Pulmonary Hypertension Research and Treatments
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Nitric Oxide and Endothelin Effects
- Genomics and Phylogenetic Studies
- Cholinesterase and Neurodegenerative Diseases
- Congenital Diaphragmatic Hernia Studies
- Medical Imaging Techniques and Applications
- Mycobacterium research and diagnosis
- Helicobacter pylori-related gastroenterology studies
- Sodium Intake and Health
- Thermoregulation and physiological responses
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Renal function and acid-base balance
- Synthesis and Biological Evaluation
- Inhalation and Respiratory Drug Delivery
- Heart Rate Variability and Autonomic Control
- Cardiac Ischemia and Reperfusion
- Pediatric health and respiratory diseases
Georgia Institute of Technology
2023-2025
Centre Chirurgical Marie Lannelongue
1989-1999
Centre National de la Recherche Scientifique
1990-1999
Hôpital Marie Lannelongue
1998
Abstract Background Microbiome restoration through fecal microbiota transplantation (FMT) is a promising decolonization approach that leads to reduction in multidrug resistant organism (MDRO) colonization and infections. The precise mechanisms by which FMT reduces MDRO are not well elucidated, long-term follow up (LTF) data from patients treated with for lacking. We enrolled participants of recently conducted trial (PREMIX, NCT02922816) LTF study estimate engraftment dynamics donor derived...
Abstract Recent genomic analyses have revealed that microbial communities are predominantly composed of persistent, sequence-discrete species and intraspecies units (genomovars), but the mechanisms create maintain these remain unclear. By analyzing closely-related isolate genomes from same or related samples identifying recent recombination events using a novel bioinformatics methodology, we show high ecological cohesiveness coupled to frequent-enough unbiased (i.e., not selection-driven)...
ABSTRACT Recent analyses of metagenomes and genomes have revealed that microbial communities are predominantly composed persistent, sequence-discrete species intraspecies units (genomovars). To advance the concept underlying genetic or ecological mechanisms maintain these discrete need to be elucidated. By analyzing closely related isolate from same samples we show high cohesiveness coupled frequent-enough unbiased (i.e., not selection driven) horizontal gene flow, mediated by homologous...
This study was performed to evaluate the morphological effects of sulfur mustard on human lung parenchyma in vitro and measure metabolites arachidonic acid which are released during acute exposure alkylating agent. Histological analysis tissue following for a period 45 min at 10 mM revealed presence paranuclear vacuoles epithelium, specifically, ciliated cells. The release were determined bath fluids by an enzymo-immunoassay. basal prostaglandin E 2 (PGE :1.36±0.33 ng/g tissue) 6- keto F 1α...
A series of monoclonal antibodies which bind to a mucin known as M1 (anti-M1 MAbs) have also been shown detect the product human gene MUC5AC. The aim this investigation was determine concentration in surface epithelium bronchial preparations by means immunohistochemistry and fluid derived from airways an immunoradiometric assay. Human ring resection material 20 patients were challenged with methacholine, leukotriene D4, or anti-immunoglobulin E. Experiments performed intact well tissues had...
Abstract There is a surfeit of bioinformatic data showing that bacteriophages abound in the enteric microbiomes humans. What contribution these viruses shaping bacterial strain and species composition gut microbiome how are phages maintained over time? To address questions, we performed experiments with Escherichia coli isolated from four fecal microbiota transplantation (FMT) doses as representative samples non-dysbiotic develop analyze properties mathematical model population evolutionary...
The aim of this study was to examine glycoconjugate secretion in human airways with and without an epithelium. Glycoconjugate release supernatants derived from vitro determined using ELISA assay anti-human mucin monoclonal antibody (MAb 3D3). This reacted strongly Le(b) antigen but also recognized Le(a) Le(y) determinants. In 11 the 34 different lung samples (32%) studied levels were below threshhold detection for assay. mean basal glycoconjugates 100+/-28 microg/g tissue (Period I; n = 23...
The circulating levels of leukotriene E4 in infants with congenital heart defects, increased pulmonary blood flow and arterial hypertension, were determined compared decreased (Tetralogy Fallot). There was no correlation (r=0.38) between the pressure (56+/-4 mmHg) (1.37+/-0.67 ng/ml blood) measured peripheral samples from hypertensive group prior to surgery. considerable variation detectable different patients. detected two groups patients similar. These data suggest that neither surgical...
Abstract Background Fecal microbiota transplantation (FMT) is a procedure that has gained popularity due to the high efficacy in treating recurrent Clostridioides difficile infections (RCDI) and other conditions associated with dysbiotic gut microbiome. Despite widespread acceptance of technique, repeating its success RCDI treatment diseases been difficult individual-level variation disease effects on emphasis taxonomic, rather than functional, microbiome analyses. We present metagenomic...