A5101805447- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Stroke Rehabilitation and Recovery
- Diabetes and associated disorders
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Immune Cell Function and Interaction
- Chinese history and philosophy
- Functional Brain Connectivity Studies
- Blood transfusion and management
- Hepatitis B Virus Studies
- Transcranial Magnetic Stimulation Studies
- Economic Zones and Regional Development
- DNA Repair Mechanisms
- Platelet Disorders and Treatments
- Brain Tumor Detection and Classification
- Advanced Computational Techniques and Applications
- Complement system in diseases
- Advanced MRI Techniques and Applications
- Advanced Data and IoT Technologies
- Employer Branding and e-HRM
- Educational Technology and Pedagogy
- IoT Networks and Protocols
- Urinary Bladder and Prostate Research
Tianjin Medical University General Hospital
2017-2024
Jishou University
2024
Yale University
2012-2021
Tianjin University
2021
Guangxi University of Science and Technology
2011
Shaanxi Normal University
2008-2011
Jiangsu University of Science and Technology
2009
Sun Yat-sen University
2009
Jiamusi University
2005-2007
Abstract Accurate lesion segmentation is critical in stroke rehabilitation research for the quantification of burden and accurate image processing. Current automated methods T1-weighted (T1w) MRIs, commonly used research, lack accuracy reliability. Manual remains gold standard, but it time-consuming, subjective, requires neuroanatomical expertise. We previously released an open-source dataset T1w MRIs manually-segmented masks (ATLAS v1.2, N = 304) to encourage development better algorithms....
Red blood cell (RBC) transfusion is a life-saving therapeutic tool. However, major complication in recipients the generation of antibodies against non-ABO alloantigens on donor RBCs, potentially resulting hemolysis and renal failure. Long-lived antibody responses typically require CD4(+) T help and, murine models, alloimmunization requires spleen. Yet, it not known how RBC-derived antigens are presented to naive cells We sought answer whether splenic dendritic (DCs) were essential for...
Abstract Penetration of the bladder permeability barrier (BPB) is a major challenge when treating diseases via intravesical delivery. To increase transurothelial migration and tissue tumor cell uptake, poly(lactic-co-glycolic acid; PLGA) nanoparticles (NP) were modified by addition low molecular weight (2.5 or 20 kDa) positively charged mucoadhesive polysaccharide, chitosan, to NP surface. In designing these NPs, we balanced adhesive properties chitosan with release bioactivity siRNA....
Fanconi anemia (FA) is characterized by developmental abnormalities, bone marrow failure, and cancer predisposition. FA cells are hypersensitive to DNA replicative stress accumulate co-transcriptional R-loops. Here, we use the Damage At RNA Transcription assay reveal colocalization of FANCD2 with R-loops in a highly transcribed genomic locus upon damage. We further demonstrate that purified human FANCI-FANCD2 (ID2) complex binds synthetic single-stranded (ssRNA) R-loop substrates high...
Abstract During RBC transfusion, production of alloantibodies against non-ABO Ags can cause hemolytic transfusion reactions and limit availability compatible blood products, resulting in anemia-associated morbidity mortality. Multiple studies have established that certain inflammatory disorders stimuli promote alloimmune responses to Ags. However, the molecular mechanisms underlying these findings are poorly understood. Type I IFNs (IFN-α/β) induced conditions associated with increased...
Motor deficit is the most common disability after stroke, and early prediction of motor outcome critical for interventions. Here, we constructed a fine map corticospinal tract (CST) understanding secondary brain changes subcortical stroke.Diffusion spectrum imaging data from 50 healthy adults were used to reconstruct maps CST with different origins, including primary area (M1), sensory (S1), premotor cortex, supplementary (SMA). Their diffusion properties correlated functions in adults. The...
This study aims to propose a comparison model of Chinese and Japanese traditional opera tunes based on deep learning (DL) artificial intelligence technology, which can be used effectively analyze classify the tune characteristics opera. To achieve this aim, multi-layered DL model, including Convolutional Neural Network, Long Short-Term Memory, Recurrent Gated Unit, is constructed In extensive experimental verification, proposed has achieved remarkable results in task classifying tunes....
RBC alloimmunization represents a significant immunological challenge for patients requiring lifelong transfusion support. The majority of clinically relevant non-ABO(H) blood group antigens have been thought to drive antibody formation through T cell–dependent immune pathways. Thus, we initially sought define the role CD4+ cells in alloantibodies KEL, one leading causes hemolytic reactions. Unexpectedly, our findings demonstrated that KEL RBCs actually possess ability induce independent or...
Red blood cell (RBC) alloimmunization can make it difficult to procure compatible RBCs for future transfusion, directly leading increased morbidity and mortality in transfusion-dependent patients. However, the factors that regulate RBC remain incompletely understood. As complement has been shown serve as a key adjuvant development of antibody responses against microbes, we examined impact on alloimmunization. In contrast component 3 (C3) an immune response following microbial exposure,...
Alloantibodies to red blood cell (RBC) antigens can cause significant hemolytic events. Prior studies have demonstrated that inflammatory stimuli in animal models and states humans, including autoimmunity viremia, promote alloimmunization. However, molecular mechanisms underlying these findings are poorly understood. Given Type 1 interferons (IFN-α/β) regulate antiviral immunity autoimmune pathology, the hypothesis IFN-α/β regulates RBC alloimmunization was tested a murine model.Leukoreduced...
Lesion load of the corticospinal tract (CST-LL), a measure overlap between stroke lesion and CST, is one strongest predictors motor outcomes following stroke. CST-LL typically calculated by using probabilistic map CST originating from primary cortex (M1). However, higher order areas also have projections that contribute to control. In this retrospective study, we examined whether evaluating additional origins more strongly associated with post-stroke severity than M1 only. We found both...
Abstract Stroke is the leading cause of adult disability worldwide, with up to two-thirds individuals experiencing long-term disabilities. Large-scale neuroimaging studies have shown promise in identifying robust biomarkers (e.g., measures brain structure) stroke recovery following rehabilitation. However, analyzing large rehabilitation-related datasets problematic due barriers accurate lesion segmentation. Manually-traced lesions are currently gold standard for segmentation on T1-weighted...
Abstract Fifty‐three lactic acid bacteria ( LAB ) strains from five species of were isolated and identified yogurt C hinese pickled vegetables. Susceptibility all the isolates to antibiotics (ampicillin, erythromycin, tetracycline, vancomycin, streptomycin) was tested with disc diffusion methods. All resistant streptomycin. Thirty‐seven seven tetracycline six ampicillin. The corresponding genetic determinants characterized by polymerase chain reaction. No antibiotic gene detected among...
Background and Purpose—Interhemispheric imbalance may provide a framework for developing new strategies to facilitate post-stroke motor recovery especially patients in chronic stage. Using effective connectivity analysis, we aimed investigate interactions between the bilateral primary cortices (M1) their correlations with M1-related structural functional changes well-recovered subcortical ischemic stroke. Methods—Twenty stroke 20 normal controls underwent multimodal magnetic resonance...
Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity spared brain areas compensate for damaged tissue. Deep grey matter structures play a critical role in control and regulation circuits. The goal this work is identify associations between volumes subcortical nuclei behaviour at different timepoints after stroke. We pooled high-resolution T1-weighted MRI scans behavioural data 828 individuals with unilateral from 28 cohorts...
Approximately 3-10% of human red blood cell (RBC) transfusion recipients form alloantibodies to non-self, non-ABO group antigens expressed on donor RBCs, with these having the potential be clinically significant in and pregnancy settings. However, majority transfused individuals never detectable alloantibodies. Expanding upon observations that children initially RBCs at a young age are less likely throughout their lives, we hypothesized "non-responders" may not only ignorant but instead...
BACKGROUND Only a fraction of red blood cell (RBC) transfusion recipients form alloantibodies, and variables determining responsiveness or nonresponsiveness are poorly understood. We others have previously shown in animal models that pretreatment with toll‐like receptor agonists mimic different types infections impacts the magnitude frequency RBC alloantibody responses. hypothesized influenza infection, coexistent transfusion, would impact responses to transfused RBCs manner dependent on...
Ultraviolet (UV) illumination/pathogen reduction effectively inactivates white blood cells (WBCs) in whole blood. Given that cotransfused WBCs may impact recipient immune responses, we hypothesized pathogen of alter responses to RBC antigens.Transgenic mice expressing a model (HOD) antigen, authentic human (hGPA or KEL) antigens, natural fluorescence (uGFP) on their RBCs were utilized as donors. Recipients transfused with fresh which riboflavin had been added treated by UV treatment after...
Few therapeutic options currently exist to prevent or mitigate transfusion-associated red blood cell (RBC) alloimmunization. We hypothesized that bortezomib, a proteasome inhibitor being utilized for HLA alloantibody and ADAMTS13 autoantibody reduction, may be beneficial in transfusion setting. Herein, we reductionist murine model test our hypothesis bortezomib would decrease RBC alloimmune responses.Wild-type mice were treated with saline transfused RBCs expressing the human KEL...
Cortical beta oscillations are reported to serve as robust measures of the integrity human motor system. Their alterations after stroke, such reduced movement-related desynchronization in primary cortex, have been repeatedly related level impairment. However, there is only little data whether brain function might directly relate structural changes stroke.This multimodal study investigated 18 well-recovered patients with stroke (mean age 65 years, 12 males) by means task-related EEG and...