A5014028674- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Renal and related cancers
- Image Enhancement Techniques
- Emergency and Acute Care Studies
- Radio Wave Propagation Studies
- Optical measurement and interference techniques
- Image and Signal Denoising Methods
- Congenital Diaphragmatic Hernia Studies
- Forecasting Techniques and Applications
- Maritime Navigation and Safety
- Neonatal Respiratory Health Research
- Diabetes and associated disorders
- Statistical Methods in Epidemiology
- Platelet Disorders and Treatments
- Computational Physics and Python Applications
Albert Einstein College of Medicine
2024
Columbia University Irving Medical Center
2023
Yale University
2017-2019
Approximately 3-10% of human red blood cell (RBC) transfusion recipients form alloantibodies to non-self, non-ABO group antigens expressed on donor RBCs, with these having the potential be clinically significant in and pregnancy settings. However, majority transfused individuals never detectable alloantibodies. Expanding upon observations that children initially RBCs at a young age are less likely throughout their lives, we hypothesized "non-responders" may not only ignorant but instead...
Factors influencing the development of alloantibodies against blood group antigens on transfused red cells are poorly defined. We hypothesised that platelets may act as a danger signal to recipients and affect humoral immune responses cells.Platelet-rich plasma prepared from wild-type C57BL/6 or CD40L knock-out donors was into recipients. Leucoreduced transgenic expressing high levels human KEL glycoprotein in an erythrocyte-specific manner (KELhi donors) were after platelets, anti-KEL...