A5087876632- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Stroke Rehabilitation and Recovery
- Motor Control and Adaptation
- Schizophrenia research and treatment
- Obsessive-Compulsive Spectrum Disorders
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- RNA Interference and Gene Delivery
- Mental Health Research Topics
- Neurological disorders and treatments
- Neural and Behavioral Psychology Studies
- Hallucinations in medical conditions
- Botulinum Toxin and Related Neurological Disorders
- Infant Health and Development
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Neural dynamics and brain function
- Music Therapy and Health
- Infant Development and Preterm Care
- CRISPR and Genetic Engineering
- Neuroscience and Music Perception
University of Bern
2020-2025
Alnylam Pharmaceuticals (United States)
2022-2025
University Hospital of Bern
2023
Dimagi (United States)
2022
Saskatchewan Health Authority
2022
Inserm
2020-2021
Centre Hospitalier Le Vinatier
2021
Université Claude Bernard Lyon 1
2021
Centre de Recherche en Neurosciences de Lyon
2021
Centre National de la Recherche Scientifique
2016-2021
Stroke is the leading cause of adult disability worldwide, with up to two-thirds individuals experiencing long-term disabilities. Large-scale neuroimaging studies have shown promise in identifying robust biomarkers (e.g., measures brain structure) stroke recovery following rehabilitation. However, analyzing large rehabilitation-related datasets problematic due barriers accurate lesion segmentation. Manually-traced lesions are currently gold standard for segmentation on T1-weighted MRIs, but...
Homology-directed repair (HDR)–based genome editing is an approach that could permanently correct a broad range of genetic diseases. However, its utility limited by inefficient and imprecise DNA mechanisms in terminally differentiated tissues. Here, we tested Repair Drive, platform technology for selectively expanding HDR-corrected hepatocytes adult mice vivo. Drive involves transient conditioning the liver knocking down essential gene, fumarylacetoacetate hydrolase ( Fah ), delivering...
Since motor learning is a key component for stroke recovery, enhancing skill crucial challenge neurorehabilitation. Transcranial direct current stimulation (tDCS) promising approach improving learning. The aim of this trial was to test the hypothesis that dual-tDCS applied bilaterally over primary cortices (M1) improves online with paretic hand and its long-term retention.Eighteen chronic patients participated in randomized, cross-over, placebo-controlled, double bind trial. During separate...
Rehabilitation for stroke patients with severe motor impairments (e.g., inability to perform wrist or finger extension on the affected side) is burdensome and difficult because most current rehabilitation options require some volitional movement retrain side. However, although these participate in therapy requiring movement, previous research has shown that they may receive modest benefits from action observation, virtual reality (VR), brain-computer interfaces (BCIs). These approaches have...
The majority of patients with schizophrenia suffer from hallucinations. While the triple-network model, which includes default mode network (DMN), central executive (CEN) and salience (SAL), has recently been applied to schizophrenia, how this framework could explain emergence hallucinations remains unclear. Therefore, complementary brain regions that have linked hallucinations, such as left hippocampus, should also be considered added model. Accordingly, present study explored effective...
Abstract Up to 70% of patients with major depressive disorder present psychomotor disturbance (PmD), but at the time understanding its pathophysiology is limited. In this study, we capitalized on a large sample examine neural correlates PmD in depression. This study included 820 healthy participants and 699 remitted ( n = 402) or current 297) Patients were further categorized as having retardation, agitation, no PmD. We compared resting-state functional connectivity (ROI-to-ROI) between...
Importance Psychomotor slowing is a frequent symptom of psychosis, impairing gross and fine motor behavior. It associated with poor outcomes functioning, no treatment available. Objective To investigate whether 15 sessions inhibitory repetitive transcranial magnetic stimulation (rTMS) may reduce psychomotor slowing. Design, Setting, Participants This was 4-arm, double-blind, randomized, sham-controlled trial at university hospital in Switzerland. Enrollment took place from March 2019 to...
Motor skill learning is one of the key components motor function recovery after stroke, especially driven by neurorehabilitation. Transcranial direct current stimulation can enhance neurorehabilitation and in stroke patients. However, neural mechanisms underlying retention stimulation-enhanced involving a paretic upper limb have not been resolved. These substrates were explored means functional magnetic resonance imaging. Nineteen chronic hemiparetic patients participated double-blind,...
Background. After stroke, deregulated interhemispheric interactions influence residual paretic hand function. Anodal or cathodal transcranial direct current stimulation (tDCS) can rebalance these abnormal and improve motor Objective. We explored whether dual-hemisphere tDCS (dual-tDCS) in participants with chronic stroke fine function 2 important aspects: precision grip dexterity. Methods. In all, 19 hemiparetic individuals mild to moderate impairment participated a double-blind, randomized...
Electroencephalography (EEG)-based brain–computer interfaces (BCIs) for motor rehabilitation aim to “close the loop” between attempted commands and sensory feedback by providing supplemental information when individuals successfully achieve specific brain patterns. Existing EEG-based BCIs use various displays provide feedback, ranging from considered more immersive (e.g., head-mounted display virtual reality (HMD-VR)) less computer screens). However, it is not clear whether improve...
Abstract Paranoia is a frequent and highly distressing experience in psychosis. Models of paranoia suggest limbic circuit pathology. Here, we tested whether resting-state functional connectivity (rs-fc) the was altered schizophrenia patients with current paranoia. We collected MRI scans 165 subjects including 89 spectrum disorders (schizophrenia, schizoaffective disorder, brief psychotic schizophreniform disorder) 76 healthy controls. assessed using Positive And Negative Syndrome Scale...
Up to 50% of patients with schizophrenia are suffering from motor abnormalities, which may contribute decreased quality life, impaired work capacity, and a reduced life expectancy by 10-20 years. However, the effect abnormalities on social global functioning, as well as, functional capacity is not clear. We hypothesized, that presence associated poorer outcomes in schizophrenia.We collected data 5 different 156 spectrum disorders: parkinsonism, catatonia, dyskinesia, neurological soft signs...
Abstract Background and Hypothesis Formal thought disorder (FTD) is a core symptom of psychosis, but its neural correlates remain poorly understood. This study tested whether four FTD dimensions differ in their association with brain perfusion structure. Study Design cross-sectional investigated 110 patients schizophrenia spectrum disorders using 3T magnetic resonance imaging (MRI). The Thought Language Disorder scale (TALD) was utilized, which comprises subscales: Objective Positive (OP),...
Motor abnormalities are highly prevalent among patients with schizophrenia spectrum disorders. Very likely, motor control processes, such as dexterity and grip force (GF), impaired in schizophrenia. We aimed to explore associations between various processes investigate whether specific predict the performance of fine movements GF. Our analyses included 198 applied well-established standardized rating scales assess five different abnormalities: psychomotor slowing (PS), neurological soft...
Psychomotor slowing is a frequent symptom of schizophrenia. Short-interval intracortical inhibition assessed by transcranial magnetic stimulation demonstrated inhibitory dysfunction in The deficit results from additional noise during information processing the motor system psychosis. Here, we tested whether cortical was linked to psychomotor and network alterations. In this cross-sectional study, included 60 patients with schizophrenia determined Salpêtrière Retardation Rating Scale, 23...
Abstract The pathophysiology of visual hallucinations in Parkinson’s disease has yet to be characterized. Although stimulus-driven (“bottom-up”) processes are known impaired, the role “top-down” remains determined. Distinguishing between conscious and non-conscious detections (i.e. access consciousness) may a valuable way monitoring top-down processes. Conscious inputs was investigated identify neural substrates underlying susceptibility disease. Seventeen healthy controls, 18 patients with...
Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering intraocular pressure (IOP), risk factor for glaucoma, but most treatments do not directly target the pathological changes to increased IOP, which can manifest as medication resistance disease progresses. To identify physiological modulators we performed genome- and exome-wide association analysis in >129,000 individuals with IOP measurements extended these findings an risk. We report identification...
The neurobiology of catatonia is still poorly understood. Particularly structural MRI studies yielded conflicting results. Heterogeneity findings was suggested to stem from specifics different rating scales. This study sought test grey matter differences between patients with catatonia, without and healthy controls using the two main instruments rating. We included 98 schizophrenia spectrum disorders 42 controls. Catatonia measured Bush Francis Rating Scale Northoff Scale. According these...