A5028223203- Gallbladder and Bile Duct Disorders
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Blood donation and transfusion practices
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Lipid metabolism and disorders
- Organ Donation and Transplantation
- Nutrition and Health in Aging
- Protein Tyrosine Phosphatases
- Folate and B Vitamins Research
- Pancreatitis Pathology and Treatment
- Cytokine Signaling Pathways and Interactions
- Diabetes Treatment and Management
- Diet and metabolism studies
- Liver Diseases and Immunity
- Pituitary Gland Disorders and Treatments
- Systemic Sclerosis and Related Diseases
- Grief, Bereavement, and Mental Health
- Organ Transplantation Techniques and Outcomes
- Bariatric Surgery and Outcomes
- Adrenal and Paraganglionic Tumors
- Endoplasmic Reticulum Stress and Disease
- Iron Metabolism and Disorders
Geisinger Health System
2018-2025
Commonwealth Medical College
2024
University of Cincinnati
2024
University of Cincinnati Medical Center
2024
Geisinger Medical Center
2023
Philadelphia College of Osteopathic Medicine
2022
Regeneron (United States)
2021-2022
ORCID
2021
Elucidation of the genetic factors underlying chronic liver disease may reveal new therapeutic targets.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) promote weight loss by suppressing appetite, enhancing satiety, regulating glucose metabolism, and delaying gastric motility. We sought to determine whether GLP-1 RA use could affect medical procedures such as EGD.
Background Using common clinical parameters, we aimed to noninvasively identify and predict metabolic dysfunction – associated steatohepatitis (MASH)/MASH with clinically significant fibrosis.
Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering intraocular pressure (IOP), risk factor for glaucoma, but most treatments do not directly target the pathological changes to increased IOP, which can manifest as medication resistance disease progresses. To identify physiological modulators we performed genome- and exome-wide association analysis in >129,000 individuals with IOP measurements extended these findings an risk. We report identification...
Despite the initial benefit from treating ERBB2-positive breast cancer with tyrosine kinase inhibitor lapatinib, resistance develops inevitably. Since expression of protein phosphatase receptor-type O (PTPRO), a member R3 subfamily receptor phosphatases (PTPs), is inversely correlated aggressiveness multiple malignancies, we decided to explore correlation between PTPRO and lapatinib in cancer. Results immunohistochemical (IHC) staining analysis levels clinicopathological parameters indicate...
Introduction: Paragangliomas are rare neuroendocrine tumors and often grouped with pheochromocytomas, a combined estimated annual incidence of approximately 900 cases in the United States. Many these incidentally discovered during autopsies, indicating that significant proportion remain undiagnosed. The limited detection rate paragangliomas can be attributed to several factors, including lack secretory function, small size, location within complex anatomical structures, variable enhancement...
Introduction: Increased serum ferritin is a commonly used blood test that reflects iron stores including liver overload. However, the interpretation of levels influenced both by and inflammation. In patients with obesity, may be elevated overload This study investigated clinical factors associated hyperferritinemia in severe obesity hepatic Methods: included 4359 had wedge biopsy documented pre-operative at time primary metabolic surgery between 2004 2021. The standard Perls’/Prussian Blue...
Abstract Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering intraocular pressure (IOP), risk factor for glaucoma, but most treatments do not directly target the pathological changes to increased IOP, which can manifest as medication resistance disease progresses. To identify physiological modulators we performed genome- and exome-wide association analysis in >129,000 individuals with IOP measurements extended these findings an risk. We report...