A5029848306- Gastrointestinal motility and disorders
- Microscopic Colitis
- Inflammatory Bowel Disease
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Eosinophilic Esophagitis
- Clostridium difficile and Clostridium perfringens research
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Celiac Disease Research and Management
- Probiotics and Fermented Foods
- Dysphagia Assessment and Management
- Colorectal Cancer Screening and Detection
- Intestinal and Peritoneal Adhesions
- Congenital gastrointestinal and neural anomalies
- Pediatric health and respiratory diseases
- Digestive system and related health
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Esophageal Cancer Research and Treatment
- Anorectal Disease Treatments and Outcomes
- Immunodeficiency and Autoimmune Disorders
Cedars-Sinai Medical Center
2016-2025
Tarbiat Modares University
2023-2025
Associated Research (United States)
2024
Washington University in St. Louis
2023
Mashhad University of Medical Sciences
2023
University of Rochester
2023
Durham University
2023
Pacific Standard
2023
University of California, San Diego
2023
Motility (United States)
2017-2022
Breath tests (BTs) are important for the diagnosis of carbohydrate maldigestion syndromes and small intestinal bacterial overgrowth (SIBO). However, standardization is lacking regarding indications testing, test methodology interpretation results. A consensus meeting experts was convened to develop guidelines clinicians research.Pre-meeting survey questions encompassing five domains; indications, preparation, performance, results, knowledge gaps, were sent 17 clinician-scientists, 10...
Background & AimsInflammatory bowel diseases (IBDs) exist worldwide, with high prevalence in North America. IBD is complex and costly, its increasing places a greater stress on health care systems. We aimed to determine the past current, future prevalences of Canada.MethodsWe performed retrospective cohort study using population-based administrative data from Alberta (2002–2015), British Columbia (1997–2014), Manitoba (1990–2013), Nova Scotia (1996–2009), Ontario (1999–2014), Quebec...
INTRODUCTION: Irritable bowel syndrome (IBS) includes diarrhea-predominant (IBS-D) and constipation-predominant (IBS-C) subtypes. We combined breath testing stool microbiome sequencing to identify potential microbial drivers of IBS METHODS: IBS-C IBS-D subjects from 2 randomized controlled trials (NCT03763175 NCT04557215) were included. Baseline carbon dioxide, hydrogen (H ), methane (CH 4 sulfide S) levels measured by gas chromatography, baseline composition was analyzed 16S rRNA...
OBJECTIVES: Colectomy rates for ulcerative colitis (UC) have been inconsistently reported. We assessed temporal trends of colectomy UC, stratified by emergent vs. elective indication. METHODS: From 1997 to 2009, we identified adults hospitalized a flare UC. Medical charts were reviewed. Temporal changes evaluated using linear regression models estimate the average annual percent change (AAPC) in surgical rates. Logistic analysis compared: (i) UC patients responding medical management...
Diarrhea-predominant irritable bowel syndrome (IBS) is diagnosed through clinical criteria after excluding "organic" conditions, and can be precipitated by acute gastroenteritis. Cytolethal distending toxin B (CdtB) produced bacteria that cause gastroenteritis, a post-infectious animal model demonstrates host antibodies to CdtB cross-react with vinculin in the gut, producing an IBS-like phenotype. Therefore, we assessed circulating anti-CdtB anti-vinculin as biomarkers for D-IBS human...
Although diabetic hepatopathy is potentially less common, it may be appropriate for addition to the list of target organ conditions related diabetes. This study was designed evaluate hepatoprotective properties green tea extract (GTE) in STZ-induced diabetes rats. Wistar rats were made through single injection STZ (75 mg/kg i.p.). The randomly divided into four groups 10 animals each: Group 1, healthy control; 2, nondiabetics treated with GTE administered orally (1.5%, w/v); 3, diabetics; 4,...
Gut microbial diversity decreases with aging, but existing studies have used stool samples, which do not represent the entire gut. We analyzed duodenal microbiome in 251 subjects aged 18-35 (n = 32), 36-50 41), 51-65 96), and 66-80 82). Decreased older is associated combinations of chronological age, number concomitant diseases, medications used, also correlated increasing coliform numbers (p < 0.0001). Relative abundance (RA) phylum Proteobacteria increases subjects, increased RA family...
Summary Background Medical therapy is standard treatment for ulcerative colitis with colectomy reserved medically refractory disease or malignancy. The introductions of ciclosporin in 1994 and anti‐ TNF 2005 have extended medical management options. Aim To determine whether the incidence rate has changed since introduction therapy. Methods Adult patients a diagnosis who subsequently underwent an urgent elective Edmonton, Canada between 1 January 1998 31 December 2011 were identified....
Small intestinal bacterial overgrowth (SIBO) is highly prevalent and associated with numerous gastrointestinal disorders, but the microbes involved remain poorly defined. Moreover, existing studies of microbiome alterations in SIBO have utilized stool samples, which are not representative entire tract. Therefore, we aimed to determine compare duodenal composition non-SIBO subjects, using aspirates from subjects undergoing standard-of-care esophagogastroduodenoscopy without colon preparation....
Most gut microbiome studies have been performed using stool samples. However, the small intestine is of central importance to digestion, nutrient absorption, and immune function, characterizing its microbial populations essential for elucidating their roles in human health disease.To characterize different intestinal segments contrast these microbiome.Male female subjects undergoing esophagogastroduodenoscopy without colon preparation were prospectively recruited. Luminal aspirates obtained...
This cross-sectional study investigates the association between glucagon-like peptide-1 receptor agonists and food retention during esophagogastroduodenoscopy.