A5043272946- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Adolescent and Pediatric Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and Medication Impact
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Primary Care and Health Outcomes
- Pharmaceutical studies and practices
- Childhood Cancer Survivors' Quality of Life
- SARS-CoV-2 and COVID-19 Research
- Meta-analysis and systematic reviews
- Viral gastroenteritis research and epidemiology
- Celiac Disease Research and Management
- Diagnosis and treatment of tuberculosis
- Child and Adolescent Health
- Intestinal Malrotation and Obstruction Disorders
- COVID-19 and healthcare impacts
- Diverticular Disease and Complications
- Healthcare cost, quality, practices
- Tuberculosis Research and Epidemiology
- Vaccine Coverage and Hesitancy
- Colorectal Cancer Screening and Detection
- Gallbladder and Bile Duct Disorders
SickKids Foundation
2007-2025
University of Toronto
2010-2025
Hospital for Sick Children
2008-2025
International Council for the Exploration of the Sea
2021-2025
McGill University
2019-2025
Trillium Health Centre
2025
University College London
2019-2025
Great Ormond Street Hospital
2021-2025
Institute for Clinical Evaluative Sciences
2015-2024
Public Health Ontario
2021-2024
Routinely collected health data, obtained for administrative and clinical purposes without specific a priori research goals, are increasingly used research. The rapid evolution availability of these data have revealed issues not addressed by existing reporting guidelines, such as Strengthening the Reporting Observational Studies in Epidemiology (STROBE). REporting studies Conducted using Data (RECORD) statement was created to fill gaps. RECORD an extension STROBE address items observational...
In pharmacoepidemiology, routinely collected data from electronic health records (including primary care databases, registries, and administrative healthcare claims) are a resource for research evaluating the real world effectiveness safety of medicines. Currently available guidelines reporting using non-randomised, data—specifically REporting studies Conducted Observational Routinely Data (RECORD) Strengthening Reporting OBservational in Epidemiology (STROBE) statements—do not capture...
<h3>Objective:</h3> Health administrative databases can be used to track chronic diseases. The aim of this study was validate a case ascertainment definition paediatric-onset inflammatory bowel disease (IBD) using data and describe its epidemiology in Ontario, Canada. <h3>Methods:</h3> A population-based clinical database patients with IBD aged <15 years define cases, patient information linked health compare the accuracy various patterns healthcare use. most accurate algorithm validated...
Abstract Intestinal microbial dysbiosis is associated with Crohn’s disease (CD). However, the mechanisms leading to chronic mucosal inflammation that characterizes this remain unclear. In report, we use systems-level approaches study interactions between gut microbiota and host in new-onset paediatric patients evaluate causality of disease. We report an altered proteome CD indicative impaired mitochondrial functions. particular, proteins implicated H 2 S detoxification are downregulated,...
Background & AimsInflammatory bowel diseases (IBDs) exist worldwide, with high prevalence in North America. IBD is complex and costly, its increasing places a greater stress on health care systems. We aimed to determine the past current, future prevalences of Canada.MethodsWe performed retrospective cohort study using population-based administrative data from Alberta (2002–2015), British Columbia (1997–2014), Manitoba (1990–2013), Nova Scotia (1996–2009), Ontario (1999–2014), Quebec...
The incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing worldwide. We used population-based health administrative data to determine national Canadian IBD incidence, prevalence, and trends over time childhood-onset IBD.We identified children <16 years (y) diagnosed with 1999-2010 from in five provinces (Alberta, Manitoba, Nova Scotia, Ontario, Quebec), comprising 79.2% the population. Standardized prevalence were calculated per 100,000 children. Annual percentage...
The risk of inflammatory bowel disease (IBD) contributed by the environment can be elucidated assessing in migrants from low prevalence to Western countries. incidence IBD immigrants Canada and their Canadian-born children was compared with nonimmigrants.A population-based cohort patients derived health administrative data linked immigration determine standardized Ontario, Canada, region birth between 1994 2010. hazard younger age at determined. Incidence for Ontario-born immigrant mothers...
International cohort studies have reported increased incidence of inflammatory bowel disease (IBD) in recent years, and Canada has among the highest rates IBD world. This study assessed prevalence Ontario, most populous province Canada, to determine changing trends age onset.We used a population-based derived from validated health administrative data consisting all Ontario residents living with 1999 2008. We determined over time using Poisson regression analysis, assessing 10-year groups,...
Routinely collected health data, for administrative and clinical purposes, without specific a priori research questions, are increasingly used observational, comparative effectiveness, services research, trials. The rapid evolution availability of routinely data has brought to light issues not addressed by existing reporting guidelines. aim the present project was determine priorities stakeholders in order guide development REporting studies Conducted using Observational Routinely-collected...
Objectives: Temporal changes for intestinal resections Crohn's disease (CD) are controversial. We validated administrative database codes CD diagnosis and surgery in hospitalized patients then evaluated temporal trends surgical resection rates. Methods: First, we International Classification of Disease (ICD)-10-CM coding Canadian Health Intervention resections. Second, used these to conduct population-based surveillance between fiscal years 2002 2010 identify adult undergoing (n=981). Annual...
Objectives To better understand the real-world impact of biologic therapy in persons with Crohn’s disease (CD) and ulcerative colitis (UC), we evaluated effect marketplace introduction infliximab on population rates hospitalisations surgeries public payer drug costs. Design We used health administrative data to study adult CD UC living Ontario, Canada between 1995 2012. an interrupted time series design segmented regression analysis evaluate IBD-related hospitalisations, intestinal...
INTRODUCTION: Canada has a high burden of inflammatory bowel disease (IBD). Historical trends IBD incidence and prevalence were analyzed to forecast the Canadian over next decade. METHODS: Population-based surveillance cohorts in 8 provinces derived from health administrative data assessed national (2007–2014) (2002–2014) IBD. Autoregressive integrated moving average models used prevalence, stratified by age, with 95% prediction intervals (PI), 2035. The annual percentage change (AAPC)...
Despite the predominance of extensive disease in children with ulcerative colitis, data concerning severe paediatric colitis are sparse. We reviewed rates and predictors response to intravenous-corticosteroid therapy a single-centre cohort long-term follow-up.99 (49% males; age 2-17 years) were hospitalised (1991-2000) for treatment (90% extensive; 49% new onset colitis). Clinical, laboratory radiographic reviewed. A population-based subset was used assess incidence. Predictors...