A5028349320- Inflammatory Bowel Disease
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Gut microbiota and health
- Eosinophilic Esophagitis
- Pharmaceutical studies and practices
- Pregnancy and Medication Impact
- Intestinal Malrotation and Obstruction Disorders
- Diverticular Disease and Complications
- Helicobacter pylori-related gastroenterology studies
- Celiac Disease Research and Management
- Diagnosis and treatment of tuberculosis
- Clostridium difficile and Clostridium perfringens research
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- Childhood Cancer Survivors' Quality of Life
- Appendicitis Diagnosis and Management
- Gastrointestinal motility and disorders
- Gastrointestinal disorders and treatments
- Anorectal Disease Treatments and Outcomes
- Microbial Metabolites in Food Biotechnology
- Gastroesophageal reflux and treatments
- Viral gastroenteritis research and epidemiology
University of Alberta
2016-2025
Stollery Children's Hospital
2017-2024
Emory University
2024
University of California, Irvine
2022
Canadian Association of Gastroenterology
2021
Monash Health
2019-2020
Monash University
2019-2020
Tel Aviv Sourasky Medical Center
2020
Auckland University of Technology
2020
University of Dundee
2019
Linezolid has antimycobacterial activity in vitro and is increasingly used for patients with highly drug-resistant tuberculosis.We enrolled 41 who had sputum-culture-positive extensively (XDR) tuberculosis not a response to any available chemotherapeutic option during the previous 6 months. Patients were randomly assigned linezolid therapy that started immediately or after 2 months, at dose of 600 mg per day, without change their background regimen. The primary end point was time...
The incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing worldwide. We used population-based health administrative data to determine national Canadian IBD incidence, prevalence, and trends over time childhood-onset IBD.We identified children <16 years (y) diagnosed with 1999-2010 from in five provinces (Alberta, Manitoba, Nova Scotia, Ontario, Quebec), comprising 79.2% the population. Standardized prevalence were calculated per 100,000 children. Annual percentage...
Background and Aims:Ulcerative colitis [UC] is associated with colonic mucosa barrier defects bacterial dysbiosis, but these features may simply be the result of inflammation. Therefore, we sought to assess whether are inherently abrogated in terminal ileum [TI] UC patients, where inflammation absent.
Inflammatory bowel diseases (IBD) are a group of complex and multifactorial disorders with unknown etiology. Chronic intestinal inflammation develops against resident bacteria in genetically susceptible hosts. We hypothesized that host immunoglobulin (Ig) G can be used to identify involved IBD pathogenesis. IgG-bound -unbound microorganisms were collected from 32 pediatric terminal ileum aspirate washes during colonoscopy [non-IBD (n = 10), Crohn disease 15), ulcerative colitis 7)],...
<h3>Background & aims</h3> Inflammatory bowel diseases (IBD) are affected by dietary factors, including nondigestible carbohydrates (fibers), which fermented colonic microbes. Fibers overall beneficial, but not all fibers alike, and some patients with IBD report intolerance to fiber consumption. Given reproducible evidence of reduced fiber-fermenting microbes in IBD, we hypothesized that remain intact select can then bind host cell receptors, subsequently promoting gut inflammation....
INTRODUCTION: Canada has a high burden of inflammatory bowel disease (IBD). Historical trends IBD incidence and prevalence were analyzed to forecast the Canadian over next decade. METHODS: Population-based surveillance cohorts in 8 provinces derived from health administrative data assessed national (2007–2014) (2002–2014) IBD. Autoregressive integrated moving average models used prevalence, stratified by age, with 95% prediction intervals (PI), 2035. The annual percentage change (AAPC)...
Evolving epidemiological data and increasing antibiotic resistance mandate an update of the European North American Societies Pediatric Gastroenterology, Hepatology Nutrition guidelines.
Definitive clinical trials of new chemotherapies for treating tuberculosis (TB) require following subjects until at least 6 months after treatment discontinuation to assess durable cure, making these expensive and lengthy. Surrogate endpoints relating failure relapse are currently limited sputum microbiology, which has sensitivity specificity. We prospectively assessed radiographic changes using 2-deoxy-2-[(18)F]-fluoro-D-glucose (FDG) positron emission tomography/computed tomography...
Canada has among the highest rates of childhood-onset IBD in world. Over 7000 children and youth under 18 years old are living with Canada, 600 to 650 16 diagnosed annually. While peak age onset is second third decades life, over past two incidence risen most rapidly 5 old. The treatment presents important challenges including therapeutic choices, risk adverse events medications, psychosocial impact on child family, increased cost health care implications transition from pediatric adult...
To determine the association between inflammatory bowel disease (IBD) and rural/urban household at time of diagnosis, or within first 5 years (y) life.Population-based cohorts residents four Canadian provinces were created using health administrative data. Rural/urban status was derived from postal codes based on population density distance to metropolitan areas. Validated algorithms identified all incident IBD cases data (Alberta: 1999-2008, Manitoba Ontario: 1999-2010, Nova Scotia:...
Background Diabetes mellitus is a risk factor for tuberculosis (TB) disease. There evidence that diabetes also influences TB severity and treatment outcomes but information incomplete some published results have been inconsistent. Methods A longitudinal cohort study was conducted at the National Masan Tuberculosis Hospital in Republic of Korea. Subjects presenting with first episode or retreatment were followed from enrollment through completion treatment. Demographic, clinical,...
Pulmonary lesions from active tuberculosis patients are thought to contain persistent, nonreplicating bacilli that arise hypoxic stress. Metronidazole, approved for anaerobic infections, has antituberculosis activity against anoxic in vitro and some animal models may target bacilli. In this double-blind, placebo-controlled trial, pulmonary multidrug-resistant subjects were randomly assigned receive metronidazole (500 mg thrice daily) or placebo 8 weeks addition an individualized background...
There is some evidence in adults that higher serum infliximab (IFX) levels are needed to adequately treat fistulizing perianal Crohn's disease (CD). However, data children lacking. We aimed determine postinduction trough IFX associated with healing of CD (PCD) at week 24. In a multicenter inception cohort study, consecutive younger than age 17 years treated between April 2014 and June 2017 who had titers measured before the fourth infusion were included. Area under receiver operating...
Canada has among the highest rates of IBD in world, and number people living with these disorders is growing rapidly. This placed a high burden on health care system Canadian economy-a that only expected to grow future. It important understand its impact society order appropriately plan for expenditures, reduce patients their families, improve quality life those afflicted IBD. In Canada, there lack public awareness Crohn's disease ulcerative colitis. Raising crucial reducing social stigma...
Objectives: Clostridium difficile(C. difficile) may worsen the prognosis of ulcerative colitis (UC). The objectives this study were to: (i) validate International Classification Diseases-10 (ICD-10) code forC. difficile; (ii) determine risk ofC. difficileinfection after diagnosis UC; (iii) evaluate effect on colectomy; and (iv) assess association betweenC. difficileand postoperative complications. Methods: sensitivity, specificity, positive predictive value (PPV), negative (NPV) calculated...
Background and aims: Canada's large geographic area low population density pose challenges in access to specialized health care for remote rural residents. We compared services use, surgical rate, specialist gastroenterologist urban inflammatory bowel disease (IBD) patients Canada. Methods: used validated algorithms that were applied population-based administrative data identify all people living with the following three Canadian provinces: Alberta, Manitoba, Ontario (ON). residents time...
Abstract Background and Aims Incidence of paediatric inflammatory bowel disease [IBD] in Canada is among the highest worldwide, age onset may be decreasing. In a multicentre nationwide inception cohort study, we examined variation phenotype IBD throughout spectrum. Methods Children aged ≥2 years [y] &lt;17y [A1 at diagnosis], with new IBD, were systematically evaluated sites Canadian Network. Prospectively recorded phenotypic data compared between groups. Results Among 1092 children (70%...
ABSTRACT Tuberculosis (TB) remains an immense public health problem in the Republic of Korea despite a more than fivefold decrease prevalence disease over last 3 decades. The rise drug-resistant TB has compounded situation. We analyzed 208 clinical isolates M. tuberculosis from National Masan Hospital by spoligotyping, IS 6110 restriction fragment length polymorphism (RFLP), and 24-locus-based mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing to...
Tuberculosis remains an important health concern in many countries. The aim of this study was to identify predictors unfavorable outcomes at the end treatment (EOT) and (EOS; 40 months after EOT) South Korea.New or previously treated tuberculosis patients were recruited into a prospective observational cohort two hospitals Korea. To EOT EOS, logistic regression analysis performed.The proportion multidrug-resistant (MDR-TB) 8.2% new cases 57.9% cases. Of cases, 68.6% cured, as 40.7% At EOT,...
Exclusive enteral nutrition (EEN) is an effective induction treatment for pediatric Crohn disease. Given the center-based variation in use and diversity practice, we constructed a survey aimed at sharing experience strategies administering EEN, stimulating further research, optimizing therapy.This was after consultation with experts designed to address key knowledge gaps. The disseminated through Pediatric IBD Porto Group of ESPGHAN, Canadian Children Network, selective experts, sent twice...
ABSTRACT Objectives: Celiac disease (CD) is an autoimmune that requires lifelong adherence to a gluten‐free diet (GFD). Adherence the GFD in childhood may be poor and adversely influence health‐related quality of life (HRQOL). The study purpose was determine sociodemographic socioeconomic factors influencing HRQOL multiethnic cohort youth with CD. Methods: A multisite (Edmonton, Hamilton, Toronto) examining child‐parent CD (n = 243) and/or mild gastrointestinal complaints (GI‐CON; n 148)...
Abstract Background Paediatric data on the association between diagnostic delay and inflammatory bowel disease [IBD] complications are lacking. We aimed to determine effect of stricturing/fistulising complications, surgery, growth impairment in a large paediatric cohort, identify predictors delay. Methods conducted national, prospective, multicentre IBD inception cohort study including 1399 children. Diagnostic was defined as time from symptom onset diagnosis &gt;75th percentile....
The aminoglycosides streptomycin, amikacin, and kanamycin the cyclic polypeptide capreomycin are all widely used in second-line therapy for patients who develop multidrug-resistant tuberculosis. We have characterized a set of 106 clinical isolates Mycobacterium tuberculosis using phenotypic drug susceptibility testing (DST) to determine extent resistance each agent cross-resistance between agents. These results were compared with polymorphisms DNA sequences ribosome-associated genes...
French Bulldogs develop a form of granulomatous colitis (GC) with histopathological resemblance to GC Boxer dogs (GCB). GCB is associated mucosally invasive Escherichia coli whose eradication correlates clinical remission.To characterize the and features, presence or absence colonic bacteria, response fluoroquinolones in GC.A total 6 histological diagnosis GC.Retrospective study medical records. Bacterial colonization was evaluated using 16S rRNA probes for eubacteria E. coli. Biopsy...