A5102860838- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Tuberculosis Research and Epidemiology
- Histone Deacetylase Inhibitors Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal and related cancers
- Renal and Vascular Pathologies
- Lung Cancer Treatments and Mutations
- Ion channel regulation and function
- RNA regulation and disease
- Autoimmune and Inflammatory Disorders
- Epilepsy research and treatment
- Infectious Diseases and Tuberculosis
- Genital Health and Disease
- Immune Cell Function and Interaction
- Innovations in Medical Education
- Signaling Pathways in Disease
- Whipple's Disease and Interleukins
- Neuroscience and Neuropharmacology Research
- RNA and protein synthesis mechanisms
- Histiocytic Disorders and Treatments
- Diversity and Career in Medicine
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
Rush University Medical Center
2024
University of Iowa Hospitals and Clinics
2024
Universidade de São Paulo
2024
University of Iowa
2016-2023
University of Massachusetts Chan Medical School
2005-2013
King's College Hospital
2003
Junctophilin-2 (JP2) is a structural protein required for normal excitation-contraction (E-C) coupling. After cardiac stress, JP2 cleaved by the calcium ion-dependent protease calpain, which disrupts E-C coupling ultrastructural machinery and drives heart failure progression. We found that stress-induced proteolysis of liberates an N-terminal fragment (JP2NT) translocates to nucleus, binds genomic DNA, controls expression spectrum genes in cardiomyocytes. Transgenic overexpression JP2NT mice...
Background Diabetes mellitus is a risk factor for tuberculosis (TB) disease. There evidence that diabetes also influences TB severity and treatment outcomes but information incomplete some published results have been inconsistent. Methods A longitudinal cohort study was conducted at the National Masan Tuberculosis Hospital in Republic of Korea. Subjects presenting with first episode or retreatment were followed from enrollment through completion treatment. Demographic, clinical,...
The aims of this study were to discover if increased circulating microRNA-21 (miR-21) expression in serum is associated with lymph node metastasis patients cervical cancer and look further into the molecular mechanism these. Whole-blood samples from 89 who have been histopathologically confirmed as having 20 control subjects collected, then association between level miR-21 was compared. Then cell lines HeLa (HPV-18 DNA, E6/E7RNA) HT-3 (HPV used confirm interaction RASA1. role RASA1 migration...
// Xin Zhan 1, * , Wenjie Yu 2, Reinaldo Franqui-Machin 3 Melissa L. Bates 4 Kalyan Nadiminti 1 Huojun Cao 5 Brad A. Amendt Yogesh Jethava Ivana Frech Fenghuang and Guido Tricot Division of Hematology, Oncology, Blood Marrow Transplantation, Department Internal Medicine, University Iowa, Iowa City, IA, USA 2 Anatomy Cell Biology Molecular & Cellular Program, Health Human Physiology, Endodontics These authors have contributed equally to this work Correspondence to: Zhan, email:...
The hippocampus is one of the most sophisticated structures in brain, owing to its complex anatomy, intriguing functions, relationship with other structures, and relevant associated symptoms. Despite being a structure analyzed for centuries, anatomy physiology human body are still extensively studied, as well pathologic conditions potential biomarkers. It can be affected by broad group diseases that classified congenital, degenerative, infectious or inflammatory, neoplastic, vascular,...
Abstract Prior DNA microarray studies suggested that IL-16 mRNA levels decrease following T cell activation, a property unique among cytokines. We examined pro-IL-16 and protein expression in resting anti-CD3 mAb-activated primary murine CD4+ cells. Consistent with the reports, fell within 4 h of this response is inhibited by cyclosporin A. Total cellular also fell, reaching nadir at 48 h. Pro-IL-16 comprises C-terminal cytokine domain an N-terminal prodomain are cleaved caspase-3. expressed...
e23282 Background: NEK2 (Never In Mitosis A-Related Kinase 2) is a centrosome/microtubule regulator that plays key role in cell cycle progression. Previous works including ours have shown also contributes to oncogenesis and cancer metastasis, its high expression correlates with poor prognosis drug resistance multiple myeloma (Zhou et al. Cancer Cell 2013). Here we investigate clinical implication adenocarcinoma of the lung. Methods: Lung lines H1299 A549 were used mechanistic studies. The...
Radiology is among the medical specialties that have made fewest gains in closing gap underrepresented minorities and women. Diversity, equity, inclusion (DEI) initiatives are important for promoting healthy learning environments trainees, health equity patients, equitable career development opportunities employees, all of which contribute to innovation today's competitive care environment. DEI committees can self-organize or form from institutional directives. These implement impactful...
Der Hippokampus kann von einer Vielzahl Erkrankungen betroffen sein, die ähnliche klinische Befunde aufweisen. Ein Bildgebungsalgorithmus zur Einteilung in noduläre (raumfordernde) und nicht bei der Eingrenzung Differenzialdiagnostik helfen. solcher Algorithmus wird im vorliegenden Beitrag vorgestellt.