A5082965289- Mitochondrial Function and Pathology
- Cardiomyopathy and Myosin Studies
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Circular RNAs in diseases
- ATP Synthase and ATPases Research
- Adipose Tissue and Metabolism
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Herpesvirus Infections and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Sexual Differentiation and Disorders
- Estrogen and related hormone effects
- Wnt/β-catenin signaling in development and cancer
- Cardiovascular Function and Risk Factors
- Pregnancy and preeclampsia studies
- Metabolism and Genetic Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Toxoplasma gondii Research Studies
- Signaling Pathways in Disease
- Pulmonary Hypertension Research and Treatments
- Endometriosis Research and Treatment
- Renal and related cancers
Jining Medical University
2019-2025
University of Iowa
2009-2024
Tianjin University of Traditional Chinese Medicine
2023
Shandong Normal University
2022
Institute of Zoology
2004-2009
Chinese Academy of Sciences
2004-2009
Zhejiang Gongshang University
2009
Louisiana State University
2006
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited understanding of intricate mechanisms underlying I/R hinders development effective therapeutic interventions. Wnt signaling pathway exhibits extensive crosstalk with various other pathways, forming a network system pathways involved in injury. This review article elucidates signaling, as well complex interplay between and including Notch,...
Junctophilin-2 (JP2) is a structural protein required for normal excitation-contraction (E-C) coupling. After cardiac stress, JP2 cleaved by the calcium ion-dependent protease calpain, which disrupts E-C coupling ultrastructural machinery and drives heart failure progression. We found that stress-induced proteolysis of liberates an N-terminal fragment (JP2NT) translocates to nucleus, binds genomic DNA, controls expression spectrum genes in cardiomyocytes. Transgenic overexpression JP2NT mice...
Cancer drug resistance stands as a formidable obstacle in the relentless fight against top five prevalent cancers: breast, lung, colorectal, prostate, and gastric cancers. These malignancies collectively account for significant portion of cancer-related deaths worldwide. In recent years, long non-coding RNAs (lncRNAs) have emerged pivotal players intricate landscape cancer biology, their roles driving are steadily coming to light. This comprehensive review seeks underscore paramount...
The devastating clinical consequences associated with human cytomegalovirus (HCMV) infection and reactivation underscores the importance of understanding triggers HCMV in dendritic cells (DC). Here we show that ERK-mediated is dependent on mitogen stress activated kinase (MSK) family. Furthermore, this MSK mediated response CREB binding to viral major immediate early promoter (MIEP). Specifically, MIEP provides target for recruitment. Importantly, phosphorylation histone H3 required promote...
CD9 is a cell surface protein that participates in many cellular processes, such as adhesion. Fertilization involves sperm and oocyte interactions including binding to oocytes sperm–oocyte fusion. Thus may play an essential role during fertilization mammals. The present study was conducted examine whether porcine gametes it the regulation of interactions. presence ovarian tissues, spermatozoa examined by immunohistochemistry, immunofluorescence immunoblotting. Sperm penetration treated with...
The triggering mechanisms underlying reactivation of human cytomegalovirus (HCMV) in latently infected persons are unclear. During latency, HCMV major immediate-early (MIE) gene expression breaks silence to initiate viral reactivation. Using quiescently HCMV-infected pluripotent embryonal NTera2 cells (NT2) model reactivation, we show that vasoactive intestinal peptide (VIP), an immunomodulatory neuropeptide, immediately and dose-dependently (1 500 nM) activates MIE expression. This response...
ABSTRACT The ways in which human cytomegalovirus (HCMV) major immediate-early (MIE) gene expression breaks silence from latency to initiate the viral replicative cycle are poorly understood. A delineation of signaling cascades that desilence HCMV MIE genes during quiescence pluripotent N-Tera2 (NT2) cell model provides insight into molecular mechanisms underlying reactivation. In this model, we show phorbol 12-myristate 13-acetate (PMA) immediately activates RNA and protein greatly increases...
Abstract Background Heat shock proteins (Hsps) are a set of highly conserved proteins, Hsp105, has been suggested to play role in reproduction. Methods Spatio-temporal expression Hsp105 rat uterus during peri-implantation period was examined by immunohistochemistry and Western blot, pseudopregnant used as control. Injection antisense oligodeoxynucleotides into pregnant uteri carried out look at effect on embryo implantation. Results Expression mainly the luminal epithelium day 1 pregnancy,...
Stanniocalcin-1 (STC-1) is a recently discovered polypeptide hormone, while stanniocalcin-2 (STC-2) subsequently identified homologue of stanniocalcin-1. Although previous studies have shown that both STC-1 and -2 are involved in various physiological processes, such as ion transport, reproduction development, their expression the uterus roles implantation early pregnancy unclear. Here we investigated regulation STC-2 rat during under conditions. We show only basal levels mRNA were detected...
Abstract Background Diabetes mellitus (DM) has been demonstrated to be a strong risk factor for development and perpetuation of atrial fibrillation (AF). However, how DM glycemic control affect the pathogenesis AF not sufficiently investigated, especially structural remodeling. Methods A total 86 patients undergoing coronary artery bypass graft surgery were enrolled in this study, with atrium sample collected operation. The divided into group ( n = 40) 46) accordingly. Demographics, clinical...
Triggers and regulatory pathways that effectively link human cytomegalovirus (HCMV) major immediate early (MIE) latent-lytic switch activation with progeny production are incompletely understood. In the quiescently infected NTera2 cell model of primitive neural stem cells, we found costimulation vasoactive intestinal peptide (V) phorbol ester (P) synergistically activated viral infection, but this effect waned over time. Coupling retinoic acid (R), an inducer neuronal differentiation, to VP...
Cancer remains a formidable adversary, challenging medical advancements with its dismal prognosis, low cure rates and high mortality rates. Within this intricate landscape, long non‑coding RNAs (lncRNAs) emerge as pivotal players, orchestrating proliferation migration of cancer cells. Harnessing the potential lncRNAs therapeutic targets prognostic markers holds immense promise. The present comprehensive review delved into molecular mechanisms underlying involvement in onset progression top...