A5036569823- Reproductive Biology and Fertility
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- Sperm and Testicular Function
- Pluripotent Stem Cells Research
- Renal and related cancers
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Ovarian function and disorders
- DNA Repair Mechanisms
- Animal Genetics and Reproduction
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Plant Molecular Biology Research
- Genetics, Aging, and Longevity in Model Organisms
- Genetic Syndromes and Imprinting
- CRISPR and Genetic Engineering
- Reproductive System and Pregnancy
- RNA modifications and cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Reproductive Health and Technologies
- Ubiquitin and proteasome pathways
Guangdong Provincial People's Hospital
2017-2025
Jinan University
2024-2025
Technion – Israel Institute of Technology
2025
First Affiliated Hospital of Hebei Medical University
2025
Guangdong Technion-Israel Institute of Technology
2025
Jiangxi Provincial Cancer Hospital
2025
Qingdao Agricultural University
2014-2024
Tianjin University
2024
Bridge University
2024
Institute of Zoology
2014-2023
The global prevalence of prediabetes and type 2 diabetes (T2D) is increasing, it contributing to the susceptibility its related epidemic in offspring. Although impacts paternal impaired fasting blood glucose intolerance on metabolism offspring have been well established, exact molecular mechanistic basis that mediates these remains largely unclear. Here we show increases through gametic epigenetic alterations. In our findings, led insulin resistance Relative controls, prediabetic fathers...
Background: Maternal obesity has adverse effects on oocyte quality, embryo development, and the health of offspring.Objectives: To understand underlying mechanisms responsible for negative maternal obesity, we investigated DNA methylation status several imprinted genes metabolism-related genes.Methods: Using a high-fat-diet (HFD)-induced mouse model analyzed in oocytes from control obese dams liver their offspring. Analysis was performed using combined bisulfite restriction analysis (COBRA)...
In animals, mtDNA is always transmitted through the female and this termed “maternal inheritance.” Recently, autophagy was reported to be involved in maternal inheritance by elimination of paternal mitochondria Caenorhabditis elegans ; moreover, immunofluorescence, P62 LC3 proteins were also found colocalize sperm after fertilization mice. Thus, it has been speculated that may an evolutionary conserved mechanism for mitochondrial elimination. However, using two transgenic mouse strains, one...
BACKGROUNDInsulin resistance (IR) and hyperinsulinemia compromise fertility in females are well-recognized characteristics of anovulatory women with polycystic ovary syndrome. Patients IR undergoing ovarian stimulation for IVF at increased risks impaired oocyte developmental competence, implantation failure pregnancy loss. However, the precise underlying mechanism remains unknown.
Icaritin, a compound from Epimedium Genus, has selective estrogen receptor (ER) modulating activities, and posses anti-tumor activity. Here, we examined icaritin effect on cell growth of human endometrial cancer Hec1A cells found that potently inhibited proliferation cells. Icaritin-inhibited was associated with increased levels p21 p27 expression reduced cyclinD1 cdk 4 expression. Icaritin also induced apoptosis accompanied by activation caspases as evidenced the cleavage endogenous...
SUN (Sad1 and UNC84 domain containing)-domain proteins are reported to reside on the nuclear membrane playing distinct roles in dynamics. SUN5 is a new member of family, with little knowledge regarding its function. Here, we generated Sun5-/- mice found that male were infertile. Most Sun5-null spermatozoa displayed globozoospermia-like phenotype but they actually acephalic spermatozoa. Additional studies revealed was located neck spermatozoa, anchoring sperm head tail, without functional...
The duration of a woman's reproductive period is determined by the size and persistence dormant oocyte pool. Specific genes are essential for follicle maintenance female fertility. mechanisms that regulate expression these poorly understood. We found cullin-ring finger ligase-4 (CRL4) complex was crucial in this process. Oocyte-specific deletion CRL4 linker protein DDB1 or its substrate adaptor VPRBP (also known as DCAF1) caused rapid loss, premature ovarian insufficiency, silencing...
The quality of metaphase II oocytes will undergo a time-dependent deterioration following ovulation as the result oocyte aging process. In this study, we determined that expression sirtuin family members (SIRT1, 2, 3) was dramatically reduced in mouse aged vivo or vitro. Increased intracellular ROS observed when SIRT1, 3 activity inhibited. frequency spindle defects and disturbed distribution mitochondria were also MII vitro after treatment with Nicotinamide (NAM), indicating inhibition may...