A5100408560- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- DNA and Nucleic Acid Chemistry
- Histone Deacetylase Inhibitors Research
- Neuroscience and Neuropharmacology Research
- Biosensors and Analytical Detection
- Ion channel regulation and function
- Nanoparticle-Based Drug Delivery
- RNA Research and Splicing
- MicroRNA in disease regulation
- Gut microbiota and health
- Biochemical Analysis and Sensing Techniques
- Neurotransmitter Receptor Influence on Behavior
- Radio Astronomy Observations and Technology
- Plant Gene Expression Analysis
- Molecular Sensors and Ion Detection
- Electrochemical sensors and biosensors
- Genomics and Chromatin Dynamics
- Proteoglycans and glycosaminoglycans research
- Pulsars and Gravitational Waves Research
- Metal-Organic Frameworks: Synthesis and Applications
- RNA modifications and cancer
- Advanced Frequency and Time Standards
- Metalloenzymes and iron-sulfur proteins
Taizhou University
2023-2025
Institute of Genetics and Developmental Biology
2020-2024
Chinese Academy of Sciences
2004-2024
University of Chinese Academy of Sciences
2020-2024
Sichuan University
2020-2024
China University of Petroleum, East China
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Qingdao University of Science and Technology
2022-2023
National Astronomical Observatories
2023
First Affiliated Hospital of Zhengzhou University
2023
Radiotherapy is one of the most widely used clinical treatments for tumors, but it faces limitations, such as poor X-ray retention at tumor site. The use radiosensitizers containing high Z elements an effective way to enhance absorption. Here, we demonstrate a simple one-step method synthesis UiO-66-NH2(Hf) metal-organic framework nanoparticles in radiotherapy. had diameter less than 100 nm and were stable physiological environment. induced apoptosis by enhancing absorption, confirmed vitro...
An effective and simple solvent-controlled synthesis of thiocyanated enaminones 2-aminothiazoles has been demonstrated from enaminones, potassium thiocyanate, N-bromosuccinimide. This process features mild reaction conditions, easy operation, short time, high yield chemoselectivity thereby provides an efficient protocol for the divergent substituted controlled by simply varying solvent. All components are commercially available or easily accessible at low cost. The potential utility these...
Abstract We have carried out the Galactic Plane Pulsar Snapshot (GPPS) survey by using Five-hundred-meter Aperture Spherical radio Telescope (FAST), most sensitive systematic pulsar in plane. In addition to more than 500 pulsars already discovered through normal periodical search, we report here discovery of 76 new transient sources with sporadic strong pulses, detected newly developed module for a single-pulse search. Their small DM values suggest that they all are rotating transients...
Plant growth and survival in nature, its process, will be affected by various factors from the environment, among which temperature has a greater impact. In recent years, extreme weather frequently appeared, of crops been increasingly environment. As an important flavoring Chinese herbal medicine crop, Zanthoxylum bungeanum is also facing harm low-temperature stress. hormones play vital role response plants to low temperatures. this study, ultra-performance liquid chromatography-tandem mass...
Blood-brain barrier (BBB) is a major to drug delivery into the brain in treatment of central nervous system (CNS) diseases. penetrating peptides (BBPs), class that can cross BBB through various mechanisms without damaging BBB, are effective candidates for CNS However, identification BBPs by experimental methods time-consuming and laborious. To discover more as drugs disease, it urgent develop computational quickly accurately identify non-BBPs. In present study, we created training dataset...
Vernicia fordii is a monoecious and diclinous species with male female flowers on the same inflorescence. Low to flower ratio one of main reasons for low yield in this species. However, little known its floral development sex determination. Here, according results scanning electron microscopy histological analysis, V. was divided into 12 stages first morphological divergence between found occur at stage 7. The are always unisexual, but present bisexual characteristics, sterile stamen...
Abstract Iron–sulfur clusters are essential cofactors found in all kingdoms of life and play roles fundamental processes, including but not limited to respiration, photosynthesis, nitrogen fixation. The chemistry iron–sulfur makes them ideal for sensing various redox environmental signals, while the physics its host proteins have been long overlooked. One such protein, MagR, has proposed as a putative animal magnetoreceptor. It forms rod-like complex with cryptochromes (Cry) possesses...
Understanding mitochondrial viscosity is crucial for comprehending cellular health and function. Therefore, accurate sensitive measurement of essential advancing medical diagnostics treatment strategies. In this study, a novel near-infrared (NIR) fluorescent probe SSN was developed, based on the dual mechanisms Excited-State Intramolecular Proton Transfer (ESIPT) Twisted Charge (TICT). incorporates thiophene-enhanced HBT structure hemicyanine moiety effective targeting. It exhibits large...
Accumulating evidence suggests that gut microbiota plays a crucial role in the development of metabolic diseases, especially type 2 diabetes mellitus (T2DM). The nutrient-rich resource Cornus Fructus (CF) showed curative effects on mellitus. However, mechanism underlying its hyperglycemic activity remains obscure. Herein, antidiabetic potential four extracts from CF, including saponin (CTS), iridoid glycoside (CIG), tannin (CT), and alcohol extract (CCA) was evaluated vivo. results all could...
Dioxygenase 12-lipoxygenase (12-LOX) plays an important role in tumorigenesis and promotes angiogenesis proliferation several tumors, including prostate breast tumors. Radiotherapy enhances the expression of 12-LOX esophageal squamous cell carcinoma (ESCC). Two types macrophages can be found tumor microenvironment. The M2 subtype accelerates progression; however, relationship between is not well established. Here, we explore this interaction its effect on ESCC to induce progression.RT-qPCR...
The Notch signaling is a key molecular pathway that regulates cell fate and development. Aberrant can lead to carcinogenesis progression of malignant tumors. However, current therapies targeting lack specificity induce high toxicity. In this report, tumor microenvironment-responsive injectable hydrogel designed load plasmid DNA complexes as cascade gene delivery system achieve precise Notch-targeted therapy colorectal cancer (CRC). hydrogels are prepared through cross-linking between...
The goal of our study was to screen tumor grade-related lncRNAs and mRNAs reveal the underlying molecular mechanism esophagus squamous cell carcinoma (ESCC).The lncRNA mRNA sequencing data were obtained from Cancer Genome Atlas (TCGA). Tumor grade correlation analysis executed, followed by functional enrichment all mRNAs. differentially expression (DEmRNAs) expressed (DElncRNAs) obtained. PPI network DEmRNA-DElncRNA interaction constructed. annotation DEmRNAs co-expressed with DElncRNAs...
Nanocrystals with high drug loading have become a viable strategy for solubilizing drugs poor aqueous solubility. It remains challenging, however, to synthesize nanocrystals sufficient stability and targeting potential. Here, we report novel nanocrystal platform synthesized using paclitaxel (PTX) Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-AEEA)-conjugated chondroitin sulfate (CS) (CS-Fmoc) via π-π stacking afford stable formulation CD44 targetability (PTX NC@CS-Fmoc). The PTX NC@CS-Fmoc...
The aim of this study was to evaluate the effects different proportions red and blue light on Toona sinensis sprouts. To end, white (WL) taken as control various qualities were compared. Vegetative parameters, bioactive components, antioxidant properties, volatile organic compounds (VOCs) examined. Results showed that (RL) significantly increased hypocotyl elongation by 59.8% compared with WL. Under (BL), fresh weight (FW) lowest but contents ascorbic acid (AsA), total phenolics (TP),...
Emerging molecular diagnostic methods are more sensitive and objective, which can overcome the intrinsic failings of morphological diagnosis. Here, a RT-PCR-based in vitro test kit (LungMe ® ) was developed characterized to simultaneously quantify DNA methylation SHOX2 RASSF1A FFPE tissue specimens. The clinical manifestations were evaluated 251 samples with specificity sensitivity 90.4 89.8%, respectively. Furthermore, quantitative analysis shows that degree correlated stages lung cancer,...