A5081618889- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Synthesis and Characterization of Pyrroles
- Oxidative Organic Chemistry Reactions
- Carbohydrate Chemistry and Synthesis
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Plant-based Medicinal Research
- Synthetic Organic Chemistry Methods
- Catalytic Cross-Coupling Reactions
- Fluorine in Organic Chemistry
- Asymmetric Synthesis and Catalysis
- Cancer Treatment and Pharmacology
- Synthesis and Reactivity of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cyclopropane Reaction Mechanisms
- Synthesis and Reactions of Organic Compounds
- Vanadium and Halogenation Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Hydrogenation and Catalysis
- Multicomponent Synthesis of Heterocycles
Henan University of Science and Technology
2015-2025
University of Wisconsin–Madison
2017-2020
Henan University
2015-2016
Nankai University
2011-2012
An effective and simple solvent-controlled synthesis of thiocyanated enaminones 2-aminothiazoles has been demonstrated from enaminones, potassium thiocyanate, N-bromosuccinimide. This process features mild reaction conditions, easy operation, short time, high yield chemoselectivity thereby provides an efficient protocol for the divergent substituted controlled by simply varying solvent. All components are commercially available or easily accessible at low cost. The potential utility these...
烯胺酮是一类非常重要的有机合成砌块, 具有易获得、储存方便、反应多样性等优点. 更重要的是, 烯胺酮是许 多杂环化合物的重要前体.最近
Comprehensive Summary Chemodivergent synthesis of benzofurans and 2,3‐dihydrobenzofurans has been realized. Under a reaction system consisting DBDMH K 2 CO 3 as promotors, controlled conditions enabled the formation two sets valuable heterocycles from tandem transformation enaminones salicylaldehydes. The key to success was identification parameters, in which imine intermediate formed by transient halogenation coupling substitution processes underwent either aldol condensation/annulation or...
Carbohydrates are synthetically challenging molecules with vital biological roles in all living systems. Selective synthesis and functionalization of carbohydrates provide tremendous opportunities to improve our understanding on the functions this fundamentally important class molecules. However, selective seemingly identical hydroxyl groups remains a long-standing challenge chemical synthesis. We herein describe practical predictable method for site-selective stereoselective alkylation...
Acute lung injury (ALI) is a respiratory failure disease associated with high mortality rates in patients. The primary pathological damage attributed to the excessive release of pro-inflammatory mediators pulmonary tissue. However, specific therapy for ALI has not been developed. In this study, series novel ferulic acid-parthenolide (FA-PTL) and acid-micheliolide (FA-MCL) hybrid derivatives were designed, synthesized, evaluated their anti-inflammatory activities vitro. Compounds 2, 4, 6...
Abstract Glycosyl isoquinoline‐1‐carboxylate was developed as a novel benchtop stable and readily available glycosyl donor. The glycosylation reaction promoted by the inexpensive Cu(OTf) 2 salt under mild conditions. copper precipitated from solution thus rendered traceless leaving group. Surprisingly, proton acceptor absorbed metal complex mixture remained at neutral pH. copper‐promoted also proven to be completely orthogonal gold‐promoted glycosylation, an iterative synthesis of...
A novel strategy to synthesize highly functionalized oxazoles has been successfully developed via a base-mediated intermolecular substitution between 2-acyloxy-2H-azirines and N-nucleophile or O-nucleophile with subsequent ring expansion of 2H-azirine intermediate. This method provides straightforward access substituted high efficiency excellent functional group compatibility under metal-free reaction conditions.
Chemodivergent synthesis of polysubstituted pyrroles and pyridines from N -allyl enaminones via tandem site-selective bromination the highly regioselective Heck reaction.
By varying the halide type and its addition rate, divergent synthesis of dibromo 1-pyrrolines, 3-azabicyclo[3.1.0]hex-2-enes, α, α-dibromo imines from N-allyl enamine was successfully achieved. 1-Pyrrolines 3-azabicyclo[3.1.0]hex-2-enes are...
Abstract We report the total synthesis of a triazole‐epothilone analogue 1 . The key step to generate macrocyclic ring and triazole was apply Cu 2 O nanoparticles (Cu O‐NPs) catalyze 1,3‐dipolar cycloaddition. conformation its bioactivity in MCF cancer cell lines were investigated.
Construction of C-N bond is one the most important areas in synthetic organic chemistry and medical chemistry.Many methods for construction have been reported over past few years.Copper-catalyzed Chan-Lam reactions represent powerful straightforward tools to construct bonds.In this paper, recent progress coupling N-compounds with (hetero)aryl boronates based on reaction mechanism, system, scope substrates, etc., reviewed.
Abstract The acyloxy group of 2‐acyloxy‐2 H ‐azirines has been displaced by carboxylic acids to generate the corresponding using potassium iodide as a promotor. This metal‐free method can be performed with wide scope substrates readily generating products in moderate high yields. It also represents an example nucleophilic substitution between esters and under reaction conditions for first time. magnified image
Various β-keto esters, 1,3-diketones, and β-oxo amides are directly converted into their corresponding α,α-dichloro-β-keto 2,2-dichloro-1,3-diketones, α,α-dichloro-β-oxo amides, respectively, in moderate to high yields, using iodobenzene dichloride dichloromethane the presence of 4 Å molecular sieves at room temperature. This process is postulated proceed via mediated sequential oxidative α-chlorination β-dicarbonyl substrates.
Abstract A NBS‐promoted C−H amination of enaminones has been developed with a variety N‐heterocycles. This methodology is highly practical as it employs inexpensive and simple NBS promotor under aerobic conditions without the additions any transition metal catalyst. The transformation proceeds by initial bromination subsequent intermolecular substitution N‐nucleophile to form C−N bond.
The collisionally activated dissociation mass spectra of the protonated and alkali metal cationized ions a triazole-epothilone analogue were studied in Fourier transform ion cyclotron resonance spectrometer. fragmentation pathway was characterized by loss unit C3H4O3. However, another with C3H2O2 identified for complex Na+, K+, Rb+, Cs+. branching ratio second increases increment size ions. Theoretical calculations based on density functional theory (DFT) method show difference binding...
A general method has been developed for the formation of glycosyl chlorides and bromides from picolinic esters under mild neutral conditions. Benchtop stable are activated by a copper(II) halide species to afford corresponding products in high yields with traceless leaving group. Rare β accessible via this route through neighboring group participation. Additionally, labile protecting groups previously not easily can be prepared.
Abstract We recently developed a novel Ir‐catalyzed dynamic kinetic isomerization reaction for Achmatowicz rearrangement products. In this update, we show that products derived from the can also undergo allylic etherification in presence of an appropriate ligand and additive to afford useful intermediates synthesis carbohydrates. The addition triphenyl phosphite shuts down pathway promotes pathway. diphenyl phosphate improved diastereoselectivity reaction. Interestingly, opposite was...
Abstract Glycosyl isoquinoline‐1‐carboxylate was developed as a novel benchtop stable and readily available glycosyl donor. The glycosylation reaction promoted by the inexpensive Cu(OTf) 2 salt under mild conditions. copper precipitated from solution thus rendered traceless leaving group. Surprisingly, proton acceptor absorbed metal complex mixture remained at neutral pH. copper‐promoted also proven to be completely orthogonal gold‐promoted glycosylation, an iterative synthesis of...
Abstract A simple and convenient one‐pot copper‐catalyzed synthesis of N ‐substituted enaminones has been demonstrated from ketones, aromatic nitriles halides. This transformation involves the aldol‐type reaction Ullmann‐type cross coupling, which features high efficient inexpensive Cu‐catalyst with broader diversification scope.
OAc) 2 /I 催化下转化成相应的酯.这个新颖的合成策略能够有效 地合成酯类化合物.该反应具有原料易得, 反应温和, 底物范围广, 非过渡金属催化等特点.