A5102914995- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Autophagy in Disease and Therapy
- Innovations in Medical Education
- Cardiac Arrest and Resuscitation
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Hydrogen's biological and therapeutic effects
- Cardiac Ischemia and Reperfusion
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiac tumors and thrombi
- Respiratory Support and Mechanisms
- Lung Cancer Treatments and Mutations
- Cardiovascular Function and Risk Factors
- Sulfur Compounds in Biology
- Sepsis Diagnosis and Treatment
- Hormonal Regulation and Hypertension
Second Military Medical University
2015-2024
Shanghai Changzheng Hospital
2014-2024
Guangxi University
2022
Guangxi Medical University
2022
University of Shanghai for Science and Technology
2022
Changhai Hospital
2004-2014
Washtenaw Community College
2012
University of Michigan–Ann Arbor
2012
UiT The Arctic University of Norway
2012
Fistula Foundation
2012
Abstract Background Autophagy plays a significant role in myocardial ischemia-reperfusion (IR) injury. So it is important to inhibit autophagy protect cardiomyocytes besides anti-apoptosis. MiRNA has been demonstrated against apoptosis during IR, while whether anti-autophagy effect not known. The aim of this study was investigate miR-204 regulated by regulating LC3-II protein, which the marker autophagosome IR Methods Adult SD rats were randomized Control and groups. group treated with 30...
We identified a gene (PRKAG2) that encodes the gamma-2 regulatory subunit of AMP-activated protein kinase (AMPK) with mutation (Arg302Gln) responsible for familial Wolff-Parkinson-White (WPW) syndrome. The human phenotype consists ventricular preexcitation, conduction abnormalities, and cardiac hypertrophy.
Background/Aims: Caffeic acid (CA) is known to possess multiple biological activities including anti-cancer activities. However, the molecular mechanisms underlying these in non-small-cell lung cancer (NSCLC) cells are not fully understood. We attempted clarify whether CA could enhance paclitaxel (PTX)-induced cytotoxicity H1299 cells. Methods: First, we tested cytotoxic effects both and normal human Bease-2b by cell proliferation experiments. Next, use Annexin V/propidium iodide apoptosis...
Background:Myxomas are the most common primary heart tumors and closely associated with embolic events.Cardiac myxomas typically arise from interatrial septum at border of fossa ovalis in left atrium.Any other location is considered atypical.Embolism, one complications myxoma, high morbidity mortality.The aim this study was to investigate risk factors for embolism patients cardiac myxoma. Material/Methods:In retrospective study, a cohort 162 surgically treated between January 1998 June 2014...
Background: Autophagy plays a significant role in myocardial ischemia reperfusion (IR) injury. Hydrogen sulfide (H2S) has been demonstrated to protect cardiomyocytes against IR injury, while whether it anti-autophagy effect not known. The aim of this study was investigate H2S regulates autophagy during injury and its possible mechanism. Methods Results: neonatal rats were randomized into Con, hypoxia-reoxygenation (HR) protection groups. severity cell evaluated by vitality (MTT) lactate...
This study aimed to evaluate whether galectin-3 (Gal-3) contributes actively atrial fibrosis both in patients and experimental fibrillation (AF) models.Mouse HL-1 cardiomyocytes were subjected rapid electrical stimulation (RES) explore Gal-3 expression secretion levels by western blotting (WB) enzyme linked immunosorbent assay (ELISA). Neonatal rat cardiac fibroblasts treated with conditioned culture medium recombinant human the activation of transforming growth factor (TGF)-β1/α-smooth...
Background. Although the neutrophil percentage-to-albumin ratio (NPAR) has proven to be a robust systemic inflammation-based predictor of mortality in wide range diseases, prognostic value NPAR critically ill patients with cardiogenic shock (CS) remains unknown. This study aimed at investigating association between admission and clinical outcomes CS using real-world data. Methods. Critically diagnosed Medical Information Mart for Intensive Care-III (MIMIC-III) database were included our...
Objective Clinical use of CHADS2 and CHA2DS2-VASc scoring systems for predicting AF following cardiac surgery have been reported in previous studies demonstrated well-validated predictive value. We sought to investigate whether the two are effective new-onset valve demonstrate its potential utility clinical assessment. Methods Medical records all patients underwent surgeries during period January 2003 December 2013 without preoperative at center our university were reviewed. The main outcome...
Epicardial adipose tissue (EAT) is associated with the incidence, perpetuation, and recurrence of atrial fibrillation (AF), elusive underlying mechanisms. We analyzed adipokine expression in samples from 20 patients sinus rhythm (SR) 16 AF. Quantitative real-time PCR showed that connective growth factor (cTGF) was significantly higher EAT than subcutaneous (SAT) or paracardial (PAT) AF, SR (P < 0.001). Galectin-3 SAT PAT 0.001), no significant differences between AF > 0.05). Leptin vaspin...
Dysregulated methylation of the promoter lncRNA LINC00472 reduces expression and subsequently up-regulates its competing endogenous RNA miR-24. In addition, JP2 can stabilize RyR2, whereas deregulation RyR2 may contribute to pathogenesis atrial fibrillation (AF). this study, we aimed study role in AF.125 AF patients 168 healthy controls were enrolled compare their miR-24, LINC00472, RyR2. A dual-luciferase reporter gene assay accompanied by real-time PCR, Western blot IHC was conducted...
Exosomes are small (30-150 nm) membrane vesicles released by cells that transmit intercellular information. As one of the contents exosomes, microRNAs (miRNAs) may play an important role in pathogenesis atrial fibrillation (AF). Exosomal miRNAs potentially function as biomarkers AF, shown many other diseases.To identify different expression level plasma exosomal between persistent AF and sinus rhythm (SR) patients, we performed high-throughput sequencing RNAs exosomes (n=4) SR patients....
Log odds of positive lymph nodes (LODDS) is a novel and promising ratio-based node (LN) staging system in many malignancies. This study aimed to evaluate the prognostic value LODDS, comprehensively compare predictive performance LODDS with American Joint Committee on Cancer (AJCC) N classification, number (NPLN), ratio (LNR) among node-positive lung squamous cell carcinoma (SCC) patients after surgery.We identified 2,561 N1/N2 stage SCC diagnosed between 2004 2014 from Surveillance,...
Molecular hydrogen has been exhibited a protective function in heart diseases. Our previous study demonstrated that hydrogen-rich saline (HRS) could scavenge free radicals selectively and alleviate the inflammatory response myocardial ischaemia/reperfusion (I/R) injury, but underlying mechanism not fully clarified.Adult (10 weeks) C57BL/6 male mice neonatal rat cardiomyocytes were used to establish I/R hypoxia/reoxygenation (H/R) injury models. H/R models treated with HRS classify mechanisms...
Cardiac tumors are rare but manifested with various clinical presentations and often cause unexpected symptoms or sudden death. The objective is to review the presentation, histopathological spectrum, mortality follow-up data of patients cardiac following surgery treatment over a period 5 years.We retrospectively collected medical records all diagnosed in between January 2008 December 2013 at center our university. Clinical histories, perioperative data, surgical findings, efficacy were...
The optimal surgical strategy for early-stage non-small cell lung cancer (NSCLC) with visceral pleural invasion (VPI) remains unclear. Due to limited prospective comparative data these modalities, the objective of current study was compare long-term survival outcomes sublobectomy (Sub) versus lobectomy (Lob) NSCLC a tumor size ≤2 cm and VPI.Patients characterized by VPI diagnosed between 2004 2013 were identified from Surveillance, Epidemiology, End Results (SEER) program. baseline...
Although serum calcium has been proven to be a predictor of mortality in wide range diseases, its prognostic value critically ill patients with cardiogenic shock (CS) remains unknown. This retrospective observational study is aimed at investigating the association admission among CS patients.Critically diagnosed Medical Information Mart for Intensive Care-III (MIMIC-III) database were included our study. The endpoints 30-day, 90-day, and 365-day all-cause mortalities. First, ionized (iCa)...
This study aims to construct and validate several machine learning (ML) algorithms predict long-term mortality identify risk factors in unselected patients post-cardiac surgery.The Medical Information Mart for Intensive Care (MIMIC-III) database was used perform a retrospective administrative study. Candidate predictors consisted of the demographics, comorbidity, vital signs, laboratory test results, scoring systems, treatment information on first day ICU admission. Four-year set as outcome....