A5100409276- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Bone health and treatments
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Chemokine receptors and signaling
- RNA modifications and cancer
- Hemoglobinopathies and Related Disorders
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- RNA Interference and Gene Delivery
- Pancreatic and Hepatic Oncology Research
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Mechanisms of cancer metastasis
- Cancer-related Molecular Pathways
- AI in cancer detection
University of Arkansas for Medical Sciences
2004-2025
Traditional Chinese Medicine Hospital of Kunshan
2012-2025
Shanghai University of Traditional Chinese Medicine
2012-2025
Shaoxing Second Hospital
2022-2025
Winthrop Rockefeller Foundation
2021-2024
Fifth Affiliated Hospital of Zhengzhou University
2023-2024
Yangzhou University
2024
Shandong First Medical University
2022-2024
University of Electronic Science and Technology of China
2024
Academy of Medical Sciences
2024
Abstract Anti-multiple myeloma B cell maturation antigen (BCMA)-specific chimeric receptor (CAR) T-cell therapies represent a promising treatment strategy with high response rates in myeloma. However, durable cures following anti-BCMA CAR-T of are rare. One potential reason is that small subset minimal residual cells seeds relapse. Residual BCMA-CAR-T-mediated show less-differentiated features and express stem-like genes, including CD24. CD24-positive large fraction after BCMA-CAR-T therapy....
Aerobic glycolysis, a hallmark of cancer, is characterized by increased metabolism glucose and production lactate in normaxia. Recently, pyruvate kinase M2 (PKM2) has been identified as key player for regulating aerobic glycolysis promoting tumor cell proliferation survival. Tandem affinity purification followed up mass spectrometry (TAP-MS) co-immunoprecipitation (Co-IP) were used to study the interaction between NIMA (never mitosis gene A)-related 2 (NEK2) heterogeneous nuclear...
Abstract Iron homeostasis is disrupted in multiple myeloma, a difficult-to-cure plasma cell malignancy with lytic bone lesions. Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA of exporter ferroportin (FPN1) significantly downregulated myeloma cells correlates negatively clinic outcome. Restoring FPN1 reduces intracellular liable pool, inhibits STAT3-MCL-1 signaling, suppresses growth. Furthermore, also at the initial stages osteoclast...
Here we demonstrate the crucial role of CKS1B in multiple myeloma (MM) progression and define CKS1B-mediated SKP2/p27 Kip1 -independent down-stream signaling pathways.Forced-expression MM cells increased cell multidrug-resistance. activates STAT3 MEK/ERK pathways.In contrast, SKP2 knockdown or p27 over-expression resulted activation pathways.Further investigations showed that BCL2 is a downstream target signaling.Stimulation pathways partially abrogated induced death growth...
Ibrutinib (Imbruvica), a small-drug inhibitor of Bruton tyrosine kinase (BTK), is currently undergoing clinical testing in patients with multiple myeloma, yet important questions on the role BTK myeloma biology and treatment are outstanding. Using flow-sorted side population cells from human cell lines primary samples as surrogate for elusive stem cell, we found that elevated expression leads to AKT/WNT/β-catenin-dependent upregulation key stemness genes (OCT4, SOX2, NANOG, MYC) enhanced...
To strengthen the development of enterprises and optimize knowledge management strategies, current situation enterprise (EKM) is investigated evaluation indicators EKM strategies are analyzed. The specific structure principles neural network algorithms studied using big data. Finally, networks (NNs) technology used to evaluate calculate weight strategy application results show that with support data, use NNs can analyze not only but also different by enterprises. When analyzing collected...
Many patients with hepatocellular carcinoma (HCC) do not respond to the first-line immune checkpoint inhibitor treatment. Immunization effective cancer vaccines is an attractive alternative approach immunotherapy. However, its efficacy remains insufficiently evaluated in preclinical studies. Here, we investigated HCC-associated self/tumor antigen, α-fetoprotein-based (AFP-based) vaccine immunization for treating AFP (+) HCC mouse models. We found that effectively induced AFP-specific CD8+ T...
// Yi Tao 1, * , Guang Yang Hongxing 2, 3, Dongliang Song 1 Liangning Hu Bingqian Xie Houcai Wang Lu Gao Minjie Hongwei Xu 4 Zhijian 5 Xiaosong Wu Yiwen Zhang Weiliang Zhu Fenghuang Zhan Jumei Shi Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School Medicine, 200072, China 2 Key Laboratory Plant Functional Genomics and Resources, Chenshan Botanical Garden, 201602, 3 Science Research Center, Chienes Academy Sciences, Internal Iowa, Iowa City, IA 52242, USA CAS...
The AAA-ATPase TRIP13 drives multiple myeloma progression. Here, we present the crystal structure of wild-type human at a resolution 2.6 Å. A small-molecule inhibitor targeting was identified on basis structure. inhibitor, designated DCZ0415, confirmed to bind using pull-down, nuclear magnetic resonance spectroscopy, and surface plasmon resonance-binding assays. DCZ0415 induced antimyeloma activity in vitro, vivo, primary cells derived from drug-resistant patients with myeloma. impaired...
Multiple myeloma (MM) growth is supported by an immune-tolerant bone marrow microenvironment. Here, we find that loss of Never in mitosis gene A (NIMA)-related kinase 2 (NEK2) tumor microenvironmental cells associated with MM suppression. The absence NEK2 leads to both fewer tumor-associated macrophages (TAMs) and inhibitory T cells. expression myeloid progenitor promotes the generation functional TAMs when stimulated conditional medium. Clinically, high increased CD8+ effector memory cells,...
In our previous study, significantly high expression levels of matrix-remodeling associated 5 (MXRA5) were identified in fresh-cultured colorectal cancer (CRC) tissues compared with their normal adjacent mucosa by differential secretome analysis. Whether MXRA5 is a potential serum biomarker CRC has not been evaluated. The aim this study was to investigate the association between and clinicopathological characteristics patients. determined quantitative real-time PCR (qRT-PCR)...
Dysregulated expression of microRNAs is often found in gastric cancer, and it contributes to the pathogenesis cancer via regulation cell cycle, proliferation, apoptosis, migration, invasion.In this study, we aimed investigate role miR-367 invasion metastasis cancer.The correlation between level clinicopathologic features 37 patients with was analyzed by using real-time polymerase chain reaction (RT-PCR). In addition, investigated effect on migration lines HS746T SGC-7901 transwell...
CKS1B is significantly upregulated in multiple myeloma and associated with poor prognosis. The identification of novel therapies essential for effective treatment patients resistant to chemotherapy. NEDD8 inhibitor MLN4924 selectively targets SCF(Skp2) activation offers a more specific approach protein degradation inhibition than total proteasomal inhibition. goal this study was evaluate whether high conditions identify mechanisms regulating drug potency.Bortezomib sensitivity assessed...
Multiple myeloma (MM), a terminally differentiated B cell malignancy, remains difficult to cure. Understanding the molecular mechanisms underlying progression of MM may identify therapeutic targets and lead fundamental shift in treatment disease. Deubiquitination, like ubiquitination, is highly regulated process, implicated almost every cellular process. deubiquitinating enzymes (DUBs) have been identified, but their regulation poorly defined. Here, we determined that TRIP13 increases...
A novel serum direct SMOS-qPCR method enables amplification of multiple miRNAs from samples without requiring separate extraction and purification steps.
To identify imaging biomarkers of primary tumors and lymph nodes in patients with stage III-IV non-small cell lung cancer (NSCLC) assess their predictive ability for treatment response (response vs. non-response) to immune checkpoint inhibitors (ICIs) after 6 months. Retrospective analysis 83 NSCLC treated ICIs. Quantitative features the maximum on contrast-enhanced CT were extracted at baseline (time point 0, TP0) 2-3 cycles immunotherapy 1, TP1). Delta-radiomics (delta-RFs) defined as net...
Abstract Introduction: Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of abnormal monoclonal plasma cells and osteolytic bone disease. The latter key feature MM, which associated with worse clinical outcomes. We have found that high cystatin E/M (CST6) expression linked to absence lytic lesions in human MM patients CST6 suppresses formation blocking osteoclast differentiation function MM. also developed B cell maturation antigen (BCMA)- chimeric...