A5113705868- Acne and Rosacea Treatments and Effects
- Pancreatitis Pathology and Treatment
- Herpesvirus Infections and Treatments
- Multiple Myeloma Research and Treatments
- Pharmacological Effects of Natural Compounds
- Pancreatic and Hepatic Oncology Research
- melanin and skin pigmentation
- Cancer therapeutics and mechanisms
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Dermatology and Skin Diseases
- Ubiquitin and proteasome pathways
- Lymphoma Diagnosis and Treatment
- Coccidia and coccidiosis research
- Bioactive Compounds and Antitumor Agents
- Pediatric Hepatobiliary Diseases and Treatments
- Skin Protection and Aging
- Phytochemical compounds biological activities
- T-cell and Retrovirus Studies
- Phagocytosis and Immune Regulation
- PI3K/AKT/mTOR signaling in cancer
- Toxin Mechanisms and Immunotoxins
Central South University
2019-2025
Xiangya Hospital Central South University
2019-2025
Beijing University of Chinese Medicine
2024
Shanghai First People's Hospital
2016-2024
Shanghai Jiao Tong University
2016-2024
Shanghai Tenth People's Hospital
2014-2023
Tongji University
2014-2023
Guangdong Provincial People's Hospital
2023
Henan Provincial People's Hospital
2021
Soochow University
2016
Abstract Background N6-methyladenosine (m6A) is the most abundant reversible methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This study aimed to explore role m6A demethylase ALKBH5 pancreatic cancer (PC). Methods The expression its clinicopathological impact were evaluated PC cohorts. effects on biological characteristics cells investigated basis gain-of-function loss-of-function analyses. Subcutaneous orthotopic models further uncovered tumour...
Rosacea is a chronic inflammatory skin disorder whose pathogenesis unclear. Here, several lines of evidence were provided to demonstrate that mTORC1 signaling hyperactivated in the skin, especially epidermis, both rosacea patients and mouse model rosacea-like inflammation. Both deletion epithelium inhibition by its specific inhibitors can block development inflammation LL37-induced model. Conversely, hyperactivation aggravated features. Mechanistically, regulates cathelicidin through...
Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin (NHL). Pterostilbene, a natural dimethylated analog resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, best our knowledge, there no study effects pterostilbene upon hematological malignancies. Herein, we report antitumor activity mechanism against DLBCL cells both in vitro vivo . We found that treatment...
Abstract Rosacea is a chronic inflammatory skin disorder with high incidence rate. Although genetic predisposition to rosacea suggested by existing evidence, the basis remains largely unknown. Here we present integrated results of whole genome sequencing (WGS) in 3 large families and exome (WES) 49 additional validation families. We identify single rare deleterious variants LRRC4, SH3PXD2A SLC26A8 families, respectively. The relevance SH3PXD2A, LRR family genes underscored presence...
Circadian disruption has been implicated in tumour development, but the underlying mechanism remains unclear. Here, we show that molecular clockwork within malignant human pancreatic epithelium is disrupted and this mediated by miR-135b-induced BMAL1 repression. miR-135b directly targets 3'-UTR thereby disturbs oscillator, downregulation of essential for realignment cellular clock. Asynchrony between expression impairs local circadian gating control suppression significantly promotes...
The AAA-ATPase TRIP13 drives multiple myeloma progression. Here, we present the crystal structure of wild-type human at a resolution 2.6 Å. A small-molecule inhibitor targeting was identified on basis structure. inhibitor, designated DCZ0415, confirmed to bind using pull-down, nuclear magnetic resonance spectroscopy, and surface plasmon resonance-binding assays. DCZ0415 induced antimyeloma activity in vitro, vivo, primary cells derived from drug-resistant patients with myeloma. impaired...
Rosacea is a chronic inflammatory cutaneous disease which mainly affects central face, leading to cosmetic disfigurement and compromised social psychology in billions of rosacea patients. Though the exact etiology remains elusive, accumulating evidence has highlighted dysfunction innate immunity inflammation pathogenesis. Disintegrin Metalloprotease ADAM-like Decysin-1 (ADAMDEC1) an orphan metalloprotease believed be closely related inflammation. Here for first time, we reported that...
Rosacea is a chronic inflammatory skin disorder of uncertain etiology. Evidence suggests the underlying pathogenesis modulated by abnormal and vascular responses. Thalidomide synthetic derivative acid with anti-inflammatory anti-angiogenic properties. However, its effects on rosacea remain unknown. To investigate thalidomide lesional alterations molecular mechanisms in rosacea. Mice were intradermally injected LL37 to induce rosacea-like features intraperitoneally administered thalidomide....
Rosacea is a common chronic inflammatory condition that mainly affects the central face. However, molecular background of normal face and transcriptional profiling immune cell composition rosacea lesions remain largely unknown. Here, we performed whole-skin epidermal RNA-seq facial skin from healthy individuals, matched patients. From RNA-seq, site-specific gene signatures for were enriched in epithelial differentiation, with upregulation activator protein-1 (AP1) transcription factor (TF)....
Abstract Aging represents a multifaceted process culminating in the deterioration of biological functions. Despite introduction numerous anti‐aging strategies, their therapeutic outcomes have often been less than optimal. Consequently, discovering new targets to mitigate aging effects is critical importance. We applied Mendelian randomization (MR) identify potential pharmacological against aging, drawing upon summary statistics from both Decode and FinnGen cohorts, with further validation an...
Rosacea is a chronic inflammatory skin disorder, whose underlying cellular and molecular mechanisms remain obscure. Here, we generate single-cell atlas of facial from female rosacea patients healthy individuals. Among keratinocytes, subpopulation characterized by IFNγ-mediated barrier function damage found to be unique lesions. Blocking IFNγ signaling alleviates rosacea-like phenotypes in mice. The papulopustular featured expansion pro-inflammatory fibroblasts, Schwann, endothelial...
Pancreatic fibrosis, a prominent feature of chronic pancreatitis (CP), induces persistent and permanent damage in the pancreas. stellate cells (PSCs) provide major source extracellular matrix (ECM) deposition during pancreatic injury, activation PSCs plays vital role progression fibrosis. Retinoic acid (RA), retinoid, has broad range biological functions, including regulation cell differentiation proliferation, attenuating progressive fibrosis multiple organs. In present study, we...
Pancreatic cancer (PC) is one of the most malignant tumors. Rapid progression and distant metastasis are main causes patient death. Hypoxia a hallmark multiple cancers involved in tumor biology. However, little known about roles circRNAs glycolysis hypoxia-mediated PC. Here, expression pattern hypoxia-related was analyzed using RNA sequencing. A unique circRNA termed circRNF13 found to be upregulated PC tissues may potential prognostic indicator. HIF-1α EIF4A3 regulating biogenesis...
Abstract Rosacea, as a progressive and chronic inflammatory skin disease, lacks safe effective treatment options. Our previous study reported metabolic disturbance in rosacea patients, containing abnormal lipid metabolism. Building on this, we characterized significant alterations fatty acid metabolism among with notable increase linoleic (LNA) levels. We further demonstrated that LNA prevents rosacea-like dermatitis LL37-induced mouse model. evidence indicated hyperactivates PPARγ signaling...
Rosmarinic Acid (RA), a caffeic acid ester, has been shown to exert anti-inflammation, anti-oxidant and antiallergic effects. Our study aimed investigate the effect of RA in sodium taurocholate ( NaTC )-induced acute pancreatitis, both vivo vitro. In vivo, (50 mg/kg) was administered intraperitoneally 2 h before injection. Rats were sacrificed 12 h, 24 or 48 after Pretreatment with significantly ameliorated pancreas histopathological changes, decreased amylase lipase activities serum,...
The role of persistent activation pancreatic stellate cells (PSCs) in the fibrosis associated with chronic pancreatitis (CP) is increasingly being recognized. Recent studies have shown that Wnt signaling involved development multiple organs, however, specific Wnts remains unknown. We investigated during PSC CP and effect β-catenin inhibition Dickkopf-related protein 1 (Dkk1) restoration on phenotype PSCs. was induced mice by repetitive caerulein injection mouse PSCs were isolated activated...