A5082368554- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Axon Guidance and Neuronal Signaling
- Anatomy and Medical Technology
- Surgical Simulation and Training
- Peripheral Neuropathies and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Sphingolipid Metabolism and Signaling
- Hereditary Neurological Disorders
- Molecular Biology Techniques and Applications
- Apelin-related biomedical research
- Parallel Computing and Optimization Techniques
- Interconnection Networks and Systems
- DNA and Nucleic Acid Chemistry
- Pharmacological Effects of Natural Compounds
- Innovations in Medical Education
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Gastrointestinal motility and disorders
- Digital Media and Visual Art
- Circadian rhythm and melatonin
- MicroRNA in disease regulation
- RNA Research and Splicing
- Analytical Chemistry and Chromatography
- Biomedical Research and Pathophysiology
Swinburne University of Technology
2021-2025
New York University
2020-2024
Nanchang University
2020-2024
Huazhong University of Science and Technology
2012-2024
Universiti Teknologi MARA
2024
La Trobe University
2021-2023
Hubei University
2022-2023
Institute of Computing Technology
2022
University of Chinese Academy of Sciences
2022
Tongji University
2022
The extracellular factors that are responsible for inducing myelination in the central nervous system (CNS) remain elusive. We investigated whether brain-derived neurotrophic factor (BDNF) is implicated, by first confirming BDNF heterozygous mice exhibit delayed CNS during early postnatal development. next established influence of upon was direct, acting on oligodendrocytes, using co-cultures dorsal root ganglia neurons and oligodendrocyte precursor cells. Importantly, we found retains its...
The neurotrophin brain-derived neurotrophic factor (BDNF) has been implicated in regulating CNS myelination. BDNF mutant mice exhibit a hypomyelinating phenotype, and exerts distinct effects upon oligodendroglial proliferation, differentiation, myelination vitro . To investigate the precise influence that vivo , we have generated conditional knock-out which TrkB deleted specifically oligodendrocytes. Deletion of disrupted normal oligodendrocyte myelination, resulting significant reduction...
Multiple extracellular factors have been implicated in orchestrating myelination of the CNS; however, less is known about intracellular signaling cascades that regulate this process. We previously shown brain-derived neurotrophic factor (BDNF) promotes oligodendrocyte myelination. Here, we screened for activation candidate pathways vitro assays and found signal-regulated kinase (Erk) positively correlated with basal levels as well BDNF-induced vitro. By selectively manipulating Erk1/2...
Methods to promote myelin regeneration in response central loss are essential prevent the progression of clinical disability demyelinating diseases. The neurotrophin brain-derived neurotrophic factor (BDNF) is known myelination during development via oligodendrocyte expressed TrkB receptors. Here, we use a structural mimetic BDNF preclinical mouse model demyelination. In female mice, show that selective targeting with BDNF-mimetic enhances remyelination, increasing differentiation, frequency...
To explore the mechanism by which microRNA-155 (miR-155) regulates pathogenesis of experimental colitis.A luciferase assay was performed to confirm binding miR-155 SHIP-1 3'-UTR. MiR-155 mimics, negative controls and expression/knockdown vectors were established then utilized in gain- loss-of-function studies raw264.7 cells primary bone marrow-derived macrophages (BMDMs). Thereafter, dextran sulfate sodium (DSS)-induced colitis mouse model with or without antagomiR-155 treatment established,...
Multiple sclerosis (MS) is a complex demyelinating disease of the central nervous system. Current research has shown that at least in some cases, primary insult MS could be directed oligodendrocyte, and earliest immune responses are primarily via innate cells. We have identified family receptor protein tyrosine kinases, known as TAM receptors (Tyro3, Axl Mertk), potentially important regulating both oligodendrocyte responses. previously Gas6, ligand for receptors, can affect severity...
Circadian disruption has been implicated in tumour development, but the underlying mechanism remains unclear. Here, we show that molecular clockwork within malignant human pancreatic epithelium is disrupted and this mediated by miR-135b-induced BMAL1 repression. miR-135b directly targets 3'-UTR thereby disturbs oscillator, downregulation of essential for realignment cellular clock. Asynchrony between expression impairs local circadian gating control suppression significantly promotes...
Fyn, a member of the Src family nonreceptor tyrosine kinases, promotes central nervous system myelination during development; however mechanisms mediating this effect remain unknown. Here we show that Fyn phosphorylation is modulated by BDNF in vivo . Concordant with this, find stimulates myelinating cocultures, an dependent on oligodendroglial expression TrkB. Importantly, PP2, pharmacological inhibitor not only abrogated promyelinating influence vitro , but also attenuated BDNF‐induced...
Abstract Anatomy is shifting toward a greater focus on adopting digital delivery. To advance and authentic learning in anatomy, flipped classroom model integrating multimodal resources multimedia group assignment was designed implemented for first‐year neuroanatomy third‐year regional anatomy curricula. A five‐point Likert scale teaching survey conducted total of 145 undergraduate health science students to evaluate students' perception the resources. This study revealed that over two‐thirds...
The coronavirus disease 2019 (Covid-19) pandemic has induced multifaceted changes in anatomical education. There been a significant increase the employment of digital technologies coupled with upskilling educators' capacity and altered attitudes toward digitalization process. While challenges remain, learners have demonstrated capabilities to adapt delivery, engagement assessment. With alternative innovative teaching learning strategies having trialed implemented for almost two years, key...
Although brain-derived neurotrophic factor (BDNF) has been shown to promote peripheral myelination during development and remyelination after injury, the precise mechanisms mediating this effect remain unknown. Here, we determine that BDNF promotes of nerve growth factor-dependent neurons, an dependent on neuronal expression p75 neurotrophin receptor, whereas inhibits BDNF-dependent neurons via full-length TrkB receptor. Thus, exerts contrasting effects Schwann cell myelination, depending...