A5103279452- Wnt/β-catenin signaling in development and cancer
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Plant Pathogens and Fungal Diseases
- Epigenetics and DNA Methylation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Myeloid Leukemia Treatments
- Extracellular vesicles in disease
- Acute Myeloid Leukemia Research
- Protease and Inhibitor Mechanisms
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Mycotoxins in Agriculture and Food
- Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Tendon Structure and Treatment
- Lymphoma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Nanoplatforms for cancer theranostics
- High Altitude and Hypoxia
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Mesenchymal stem cell research
- Advanced Glycation End Products research
- Aldose Reductase and Taurine
The University of Texas MD Anderson Cancer Center
2005-2025
Fujian Medical University
2021-2024
Union Hospital
2021-2024
East China Normal University
2012-2024
First Affiliated Hospital of Fujian Medical University
2021-2024
University of Oklahoma Health Sciences Center
2021-2023
Wake Forest University
2023
Huazhong University of Science and Technology
2018-2022
Tongji Hospital
2018-2022
Ochsner Medical Center
2012-2019
Abstract Matrix metalloproteinase-1 (MMP1) has an aberrant expression relevant to various behaviors of cancers. As dominant components the tumor stroma, fibroblasts constitute important source metalloproteinase (MMPs) including mainly MMP1. The impacts MMP1 derived from in microenvironment, however, is not well defined. In this study, we demonstrated a part crosstalk between and cancer cells that enhanced invasiveness cells, IL8-induced activation STAT3 signaling pathway as key promoter...
Abstract Background Previous studies have investigated the sustained aberrantly activated Interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is crucial for pancreatic cancer growth metastasis. Suppressor cytokine (SOCS3), as a key negative feedback regulator this pathway, usually down-regulated in various cancers. In present study, we aim at exploring biological function underlying molecular regulation mechanisms SOCS3 cancer. Methods The...
Activation of p53 effectively inhibits tumor angiogenesis that is necessary for growth and metastasis. Reactivation the by small molecules has emerged as a promising new strategy cancer therapy. Several classes small-molecules activate pathway have been discovered using various approaches. Here, we identified harmine (β-carboline alkaloid) novel activator signaling involved in inhibition growth. Harmine induced phosphorylation disrupted p53-MDM2 interaction. also prevented degradation...
Circadian disruption has been implicated in tumour development, but the underlying mechanism remains unclear. Here, we show that molecular clockwork within malignant human pancreatic epithelium is disrupted and this mediated by miR-135b-induced BMAL1 repression. miR-135b directly targets 3'-UTR thereby disturbs oscillator, downregulation of essential for realignment cellular clock. Asynchrony between expression impairs local circadian gating control suppression significantly promotes...
Macular edema caused by retinal vascular leakage and ocular neovascularization are the leading causes of severe vision loss in diabetic retinopathy (DR) age-related macular degeneration (AMD) patients. Oral administration fenofibrate, a PPARα agonist, has shown therapeutic effects on To improve drug delivery to retina its efficacy, we have developed nano-emulsion-based fenofibrate eye drop formulation that delivered significantly higher amounts compared systemic administration, as measured...
Diabetes can result in impaired corneal wound healing. Mitochondrial dysfunction plays an important role diabetic complications. However, the regulation of mitochondria function cornea and its impacts on healing remain elusive. The present study aimed to explore molecular basis for disturbed mitochondrial metabolism subsequent impairment cornea. Seahorse analysis showed that oxidative phosphorylation is a major source ATP production human epithelial cells. Live biopsy punches from type 1 2...
Summary Follicular lymphoma ( FL ) comprises nearly 25% of non‐ H odgkin cases and is clinically characterized by initial sensitivity to chemotherapy followed relapse. stroma contains a special type stromal cell found in the germinal centre lymph nodes—the follicular dendritic FDC ). We first isolated tumourigenic cells from line FLK ‐1 side population SP technique, that cells, which express ABCG 2, were enriched radiation treatments. In vitro , attracted adhered s through chemokine C ‐ X...
Abstract Pancreatic cancer ( PC ) is an aggressive malignancy associated with a poor prognosis and low responsiveness to chemotherapy radiotherapy. Most patients have metastatic disease at diagnosis, which partly accounts for the high mortality from this disease. Here, we explored role of transcription factor sex‐determining region Y‐box (Sox) 6 in invasiveness cells. We showed that Sox6 down‐regulated association overexpression suppressed cell proliferation migration vitro tumour growth...
Extracellular vesicles (EVs) are generated in all cells. Systemic administration of allogenic EVs derived from epithelial and mesenchymal cells has been shown to be safe, despite carrying an array functional molecules, including thousands proteins. To address whether cell-derived can modified acquire the capacity induce immune response, we engineered 293T harbor immunomodulatory molecules CD80, OX40L, PD-L1. We demonstrated abundant levels these proteins EVs. Functionally, efficiently...
Background FFAs play an important role in the obesity management. Recent studies suggest that BFR training may also influence metabolic responses, including regulation of bloodstream. Understanding how acute resistance affects could provide valuable insights into effective interventions for improving health this population. Methods A two-arm randomized controlled design was employed. total 22 eligible subjects were randomly divided BFR-RE (n=11) and RE group (RE, n=11). Each participant...
It was reported previously that circulation levels of kallistatin, an endogenous Wnt signaling inhibitor, are increased in patients with diabetes. The current study conducted to determine the role kallistatin delayed wound healing diabetic corneas. Immunostaining and Western blot analysis showed were upregulated corneas from humans rodents In murine corneal models, canonical activated nondiabetic suppressed corneas, correlating healing. Transgenic expression activation cornea Local...
Background. Diabetic keratopathy (DK) poses a significant challenge in diabetes mellitus, yet its molecular pathways and effective treatments remain elusive. The aim of our research was to explore the pyroptosis-related genes corneal epithelium streptozocin-induced diabetic rats. Methods. After sixteen weeks streptozocin intraperitoneal injection, from three rats normal groups underwent whole-transcriptome sequencing. An integrated bioinformatics pipeline, including differentially expressed...
To investigate the regulatory mechanism of glycogen synthase kinase 3β (GSK3β) in epithelial-mesenchymal transition (EMT) process after proliferative vitreoretinopathy (PVR) induction.Experimental PVR was induced by intravitreal injection retinal pigment epithelium (RPE) cells eyes rabbits. A PI3K/Akt inhibitor (wortmannin) and a GSK3β (LiCl) were also injected at different time during progress. Electroretinogram (ERG), ocular fundus photographs, B-scan ultrasonography used to observe...
Fusarium asiaticum belongs to one of the phylogenetical subgroups F. graminearum species complex and is epidemically predominant in East Asia area. The life cycle significantly regulated by light. In this study, fungal blue light receptor white collar (WCC), including FaWC1 FaWC2, were characterized asiaticum. knockout mutants ΔFawc1 ΔFawc2 generated replacing target genes via homologous recombination events. two showed similar defects light-induced carotenoid biosynthesis, UV-C resistance,...
Tumor budding (TB) is emerging as a prognostic factor in multiple cancers. Likewise, the stemness of cancer cells also plays vital role progression. However, nearly no research has focused on interaction TB and tumor cancer.Tissue microarrays including 229 cases invasive breast (BC) were established subjected to pan-cytokeratin immunohistochemical staining evaluate molecular expression. Univariate multivariate analyses applied identify factors BC, Chi-square test was used for comparison...
Acute myeloid leukemia (AML) with the t(8;21) (q22;q22) creating AML1-ETO fusion gene is a distinct type of AML generally associated favorable prognosis. The clinicopathologic features carrying variant are less well characterized. We report 4 cases characterized by ins(8;21)(q22;q22q22), t(1;21;8)(q25;q22;q22), t(8;11;21)(q22;q13;q22), and t(4;21;8;12)(q31.3;q22;q22;q15), respectively. Fluorescence in situ hybridization or reverse transcriptase–polymerase chain reaction assay confirmed...
Abstract Cell migration and invasion are key processes in the metastasis of cancer, suppression these steps is a promising strategy for cancer therapeutics. The aim this study was to explore small molecules treating colorectal ( CRC ) investigate their anti‐metastatic mechanisms. In study, six cell lines were used. We showed that YH ‐306 significantly inhibited cells dose‐dependent manner. addition, adhesion protrusion formation HCT 116 HT ‐29 cells. Moreover, potently suppressed uninhibited...
Acute myeloid leukemia (AML) with the t(8;21) (q22;q22) creating AML1-ETO fusion gene is a distinct type of AML generally associated favorable prognosis. The clinicopathologic features carrying variant are less well characterized. We report 4 cases characterized by ins(8;21)(q22;q22q22), t(1;21;8)(q25;q22;q22), t(8;11;21)(q22;q13;q22), and t(4;21;8;12)(q31.3;q22;q22;q15), respectively. Fluorescence in situ hybridization or reverse transcriptase-polymerase chain reaction assay confirmed...