A5100382543- Retinal Diseases and Treatments
- Ion Transport and Channel Regulation
- Effects of Radiation Exposure
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Hormonal Regulation and Hypertension
- Glaucoma and retinal disorders
- Cardiovascular Health and Disease Prevention
- Chemokine receptors and signaling
- Hedgehog Signaling Pathway Studies
- Inflammatory mediators and NSAID effects
- Chemotherapy-induced organ toxicity mitigation
- Immunotherapy and Immune Responses
- Genetics and Neurodevelopmental Disorders
- Mesenchymal stem cell research
- Corneal Surgery and Treatments
- Genetic Associations and Epidemiology
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Eicosanoids and Hypertension Pharmacology
- Corneal surgery and disorders
- Neurotransmitter Receptor Influence on Behavior
- Retinal Development and Disorders
- Cholesterol and Lipid Metabolism
- Gout, Hyperuricemia, Uric Acid
Second Artillery General Hospital of Chinese People's Liberation Army
2024
Dalian Municipal Central Hospital
2016-2023
Dalian University of Technology
2023
Dalian Medical University
2013-2022
Air Force Medical University
2022
Union Hospital
2019-2021
Fujian Medical University
2019-2021
General Hospital of Shenyang Military Region
2021
Weatherford College
2021
Johns Hopkins University
2019-2020
Abstract 17β-hydroxysteroid dehydrogenase-13 is a hepatocyte-specific, lipid droplet-associated protein. A common loss-of-function variant of HSD17B13 (rs72613567: TA) protects patients against non-alcoholic fatty liver disease with underlying mechanism incompletely understood. In the present study, we identify serine 33 17β-HSD13 as an evolutionally conserved PKA target site and its phosphorylation facilitates lipolysis by promoting interaction ATGL on droplets. Targeted mutation Ser33 to...
// Muhammad Noman Khan 1, 2 , Bing Wang Jing Wei Yingqiu Zhang 1 Qiang Li 3 Xuelin Luan Jya-Wei Cheng 4 John R. Gordon 5 Fang Han Liu Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China Department Immunology, Jilin College, Jilin, Biotechnology, Life Science, National Tsing Hua Hsinchu, Taiwan The Division Respirology, Critical Care and Sleep Medicine, Royal University Hospital, Saskatchewan, Saskatoon, Canada Correspondence to: Li, e-mail: lifang16@hotmail.com Liu,...
Macular edema caused by retinal vascular leakage and ocular neovascularization are the leading causes of severe vision loss in diabetic retinopathy (DR) age-related macular degeneration (AMD) patients. Oral administration fenofibrate, a PPARα agonist, has shown therapeutic effects on To improve drug delivery to retina its efficacy, we have developed nano-emulsion-based fenofibrate eye drop formulation that delivered significantly higher amounts compared systemic administration, as measured...
Background Hyperuricemia (HUA) has attracted wide attention due to its close relationship with gout, hypertension, hypertriglyceridemia, obesity, atherosclerotic heart disease, type 2 diabetes and chronic kidney disease. Clinical observations suggest that people high levels of serum uric acid (sUA) exhibits impaired urine concentration. We speculate UA may regulate the expression AQPs through inflammatory pathways, resulting in renal Methods results revealed patients mice HUA had a polyuria...
The critical role played by IgE in allergic asthma is well-documented and clinically precedented, but some patients whom neutralization may still offer clinical benefit are excluded from treatment with the existing anti-IgE therapy, omalizumab, due to high total levels or body mass. In this study, we sought generate a novel affinity antibody (MEDI4212) potential treat broad severe patient population. Analysis of mass, allergen-specific cohort asthmatics was used support rationale for...
The "myodural bridge" was described in literatures as a dense fibrous tissue connecting the sub-occipital musculature with spinal dura mater human studies. Now concept of perceived an exact anatomical structure presumably essential for critical physiological functions body, and might exist other mammals well. To determine existence to lay foundation functional study, we examined representatives five different mammalian orders. Based on dissections, P45 plastinated sections histological...
Premature senescence of bone marrow-derived mesenchymal stem cells (BMSC) remains a major concern for their application clinically. Hedgehog signaling has been reported to regulate aging-associated markers and MSC skewed differentiation. Indian (IHH) is ligand intracellular pathway considered as an inducer in chondrogenesis human BMSC. However, the role IHH aging BMSC still unclear. This study explored obtained from samples senescent mice. Isolated were transfected with siRNA or incubated...
Non-small cell lung cancer (NSCLC) constitutes the majority of all lung-cancer cases. Aquaporin 5 (AQP5) may be involved in NSCLC by promoting initiation and progression. The present study aimed to determine role AQP5 migration angiogenesis using cells HUVECs. AQPs 1, 3, 4, 5, 8 9 were screened line H1299, results showed that mRNA was upregulated compared with other AQP genes. At protein level, significantly increased H1299 16HBE cells. knockdown decreased untransfected cells, as...
CD4+CXCR5+ICOS+ T cells, known as Tfh (T Follicular helper) are required for antibody production. Abnormal production and differentiation of cells involved in many autoimmune diseases, including rheumatoid arthritis (RA). Leptin has the property modulating immune system. Here, we explored effect leptin on RA patients. Serum levels were measured by enzyme-linked immunosorbent assay (ELISA). Peripheral blood mononuclear (PBMC) stimulated with CD3/CD28 cultured presence absence or without...
Background The purpose of the present study was to find optimal threshold glycated hemoglobin (HbA1c) for diagnosis diabetes mellitus in Chinese individuals. Methods A total 8 391 subjects (including 2 133 men and 6 258 women) aged 40–90 years with gradable retinal photographs were recruited. relationship between HbA1c diabetic retinopathy (DR) examined. Receiver operating characteristic (ROC) curves used screening DR diagnosing diabetes. Results values patients significantly higher than...
Objectives: To analyze the further immunomodulatory effects of endoplasmic reticulum (ER)-stressed umbilical cord-derived mesenchymal stem cells MSCs (UC-MSCs) on rheumatoid arthritis (RA) CD4+CXCR5+ICOS+ T (follicular helper-like T, Tfh) cells.Methods: were isolated from cord and surface markers identified by flow cytometry. CD4+ purified RA patients' peripheral blood mononuclear (PBMCs) using immunomagnetic beads. Thapsigargin (Tg)-stimulated or unstimulated co-cultured with cells....
Dopamine (DA) has been implicated in the pathophysiol-ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to dopaminergic (DAergic) system are good candidate for One receptors DA receptor is dopa-mine 5 (DRD5). Single nucleotide polymorphisms (SNPs) regulatory regions DRD5 gene may affect expression, influence biosynthesis and underlie various neuropsychiatric disorders re-lated dysfunction. The present study explored association SNPs within with paranoid...
Liver X receptors (LXRs) including LXRα and LXRβ are nuclear receptor transcription factors play an important role in lipid glucose metabolism. It has been previously reported that mice lacking but not develop a severe urine concentrating defect, likely via central mechanism. Here we provide evidence regulates water homeostasis through increasing aquaporin 2 (AQP2) protein levels renal collecting ducts. LXRβ-/- exhibited reduced response to desmopressin (dDAVP) stimulation, suggesting the...
AIM: To investigate the effect of interleukin-8 (IL-8) on neural retinal ganglion cells (RGCs) and whether it can be alleviated by G31P. METHODS: RGC-5 were exposed to IL-8 with or without its specific receptor antagonist G31P for 24h, cell viability was assessed Cell Counting Kit 8 (CCK-8). Apoptosis measured examining nuclear morphology quantifying flow cytometry. Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) Western blot used expression apoptosis-related...
Nose, M., Wang, B., Itsukaichi, H., Yukawa, O., Hayata, I., Yamada, T. and Ohyama, H. Rescue of Lethally Irradiated Mice from Hematopoietic Death by Pre-exposure to 0.5 Gy X Rays without Recovery Peripheral Blood Cell Depletion its Modification OK432. Radiat. Res. 156, 195–204 (2001).Exposing mice rays 2 weeks before lethal irradiation has been reported induce marked radioresistance rescue them hematopoietic death. Here we examined effects the 0.5-Gy pre-exposure on hematological changes in...
Klebsiella pneumoniae -associated pathology is largely mediated by neutrophilic inflammation. In this study, we administered to experimental guinea pig groups and the ELR-CXC chemokine antagonist<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mtext>CXCL8</mml:mtext></mml:mrow><mml:mrow><mml:mfenced...
In the last years, serotonin (5-HT) has been related with pathophysiology of several psychiatric disorders, including schizophrenia.Thus, genes to serotonergic (5-HTergic) system are good candidate for schizophrenia.The rate-limiting enzyme 5-HT synthesis is tryptophan hydroxylase 2 (TPH2).Single nucleotide polymorphisms (SNPs) in regulatory regions TPH2 gene may affect expression and biosynthesis triggering various neuropsychiatric disorders dysfunction.The present study explored...