A5024727213- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Sesquiterpenes and Asteraceae Studies
- Plant Physiology and Cultivation Studies
- Synthesis and biological activity
- Phytochemistry and Biological Activities
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Bioactive natural compounds
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Advanced Cellulose Research Studies
- Genomics, phytochemicals, and oxidative stress
- Cytokine Signaling Pathways and Interactions
- Plant biochemistry and biosynthesis
- Biofuel production and bioconversion
- Gastric Cancer Management and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Chemical Synthesis and Reactions
- Phytochemical Studies and Bioactivities
- Phytochemistry and biological activity of medicinal plants
- Ginseng Biological Effects and Applications
- Chromatography in Natural Products
- Marine Sponges and Natural Products
- Liver Disease Diagnosis and Treatment
University of Karachi
2019-2025
International Center for Chemical and Biological Sciences
2019-2025
University of the Punjab
2012-2025
The University of Agriculture, Peshawar
2016-2024
Memorial Hospital
2020-2024
London Health Sciences Centre
2024
École de Technologie Supérieure
2024
Ohio University
2023-2024
Guangzhou Medical University
2023
Henan Provincial People's Hospital
2022-2023
Introduction: Human gut microbiota is believed to be directly or indirectly involved in cardiovascular diseases and hypertension. However, the identification functional status of hypertension-related microbe(s) have not yet been surveyed a comprehensive manner. Methods: Here we characterized microbiome hypertension by comparing fecal samples 60 patients with primary gender-, age-, body weight-matched healthy controls based on whole-metagenome shotgun sequencing. Results: Hypertension...
Abstract Glioblastoma multiforme (GBM) is the most malignant and aggressive primary brain tumor in adults. Despite concerted efforts to improve current therapies, prognosis of glioblastoma remains very poor. Alantolactone, a sesquiterpene lactone compound, has been reported exhibit antifungal, antibacteria, antihelminthic, anticancer properties. In this study, we found that alantolactone effectively inhibits growth triggers apoptosis cells time‐ dose‐dependent manner. The...
Signal transducer and activator of transcription 3 (STAT3) constitutively expresses in human liver cancer cells has been implicated apoptosis resistance tumorigenesis. Alantolactone, a sesquiterpene lactone, shown to possess anticancer activities various cell lines. In our previous report, we showed that alantolactone induced U87 glioblastoma via GSH depletion ROS generation. However, the molecular mechanism remained unexplored. The present study was conducted envisage alantolactone-induced...
Alantolactone (ALT), a sesquiterpene lactone component of Inula helenium, has been reported to exert anticancer activity in various cancers. However, the cellular targets and underlying mechanism ALT cancers including lung cancer not fully defined. In present study, we found that effectively inhibits proliferation triggers oxidative stress mediated-apoptosis A549 adenocarcinoma cells by inducing ER mitochondrial dysfunction. This ALT-mediated apoptosis was inhibited NAC while diamide...
Isoalantolactone, a sesquiterpene lactone compound possesses antifungal, antibacteria, antihelminthic and antiproliferative activities.In the present study, we found that isoalantolactone inhibits growth induces apoptosis in pancreatic cancer cells.Further mechanistic studies revealed induction of is associated with increased generation reactive oxygen species, cardiolipin oxidation, reduced mitochondrial membrane potential, release cytochrome c cell cycle arrest at S phase.N-Acetyl Cysteine...
Artemisia argyi is a widely used medicinal plant in China. The present study was designed to identify the bioactive constituents with antiglioma activity from leaves of Artemesia . A bioactivity guided approach based on MTT assay for cells growth inhibition led isolation flavonoid, “jaceosidin” ethanol extract inhibitory effect jaceosidin explored using flow cytometry and Western blot studies. Our results showed that exerts by arresting at G2/M phase induction apoptosis. Furthermore, our...
// Muhammad Noman Khan 1, 2 , Bing Wang Jing Wei Yingqiu Zhang 1 Qiang Li 3 Xuelin Luan Jya-Wei Cheng 4 John R. Gordon 5 Fang Han Liu Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China Department Immunology, Jilin College, Jilin, Biotechnology, Life Science, National Tsing Hua Hsinchu, Taiwan The Division Respirology, Critical Care and Sleep Medicine, Royal University Hospital, Saskatchewan, Saskatoon, Canada Correspondence to: Li, e-mail: lifang16@hotmail.com Liu,...
Deoxyelephantopin (DET), a naturally occurring sesquiterpene lactone present in Chinese medicinal herb, Elephantopus scaber has been shown to exert anti-inflammatory as well anticancer effects various cancer cells of human origin vitro. However, the exact molecular mechanism underlying DET-induced apoptosis remains largely unexplored, particularly hepatocellular carcinoma G2 (HepG2) cells. In study, we found that DET inhibits proliferation and induces HepG2 dose-dependent manner. This...
The present study was based on the production of bioethanol from alkali-pretreated seed pods Bombax ceiba. Pretreatment is necessary to properly utilize for via fermentation. This process assures accessibility cellulase cellulose found in seedpods by removing lignin. Untreated, KOH-pretreated, and KOH-steam-pretreated substrates were characterized morphological, thermal, chemical changes scanning electron microscopy (SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), Fourier...
Abstract SnO 2 nanoparticles accompanied by various concentrations of Ce as dopant material were prepared to extend the optical absorption spectrum near visible spectrum. The Ce-doped NPs at 0.5% (w/w) exhibit significantly higher photocatalytic ability compared pure . This enhancement has potential applications in environmental remediation, energy storage, and optoelectronic devices. microstructures properties samples characterized XRD, FTIR, EDS, SEM, UV–vis DRS. results showed that are...
Cardiac glycosides are natural compounds used for the treatment of cardiovascular disorders. Although originally prescribed diseases, more recently, they have been rediscovered their potential use in cancer. Proscillaridin A (PSD-A), a cardiac glycoside component Urginea maritima, has reported to exhibit anticancer activity. However, cellular targets and mechanism PSD-A various cancers including lung cancer remain largely unexplored. In present study, we found that inhibits growth induces...
Inflammation is recognized as a crucial contribution to diabetic nephropathy (DN). CXCL8 binds its CXC chemokine receptors (CXCR1 and CXCR2) for recruiting neutrophil infiltration initiates tissue inflammation. Therefore, we explored the effect of CXCR1 CXCR2 inhibition on DN. This was achieved by CXCL8(3-72)K11R/G31P (G31P), an antagonist that has exhibited therapeutic efficacy in inflammatory diseases malignancies. In this study, found renal leukocyte accumulation rapid increases occurred...
Abstract PTX3, a member of the long pentraxin subfamily, associated with innate immunity is indispensable for resistance to some cancer. Gemcitabine, an analog cytosine arabinoside, has shown restrained benefits because profound chemoresistance. The PTX3 expression on GEM in human lung cancer cells have not yet been clarified; present study aimed show reactive oxygen species (ROS) mediatory through distinct mechanisms. Whereas ginsenoside Rg3 herbal medicine strong antitumor activity....
Sesquiterpene lactones have been shown to be promising leads for anticancer drug development. Brevilin A (BLN-A), a sesquiterpene lactone compound of Centipeda minima has exhibit effects against various cancer cells. However, the mechanism and cellular targets BLN-A remain elusive. Here in this study, inhibits proliferation induces cell morphological changes A549 NCI-H1650 non-small lung cells dose-dependent manner. Moreover, increased ROS generation bax/bcl-2 ratio while decreased...