A5004967071- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Renal and related cancers
- HIV/AIDS drug development and treatment
- Sphingolipid Metabolism and Signaling
- RNA Interference and Gene Delivery
- Vitamin D Research Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Multiple Sclerosis Research Studies
- Ion channel regulation and function
- Peripheral Neuropathies and Disorders
- Adolescent Sexual and Reproductive Health
- MicroRNA in disease regulation
- Sesquiterpenes and Asteraceae Studies
- Mesenchymal stem cell research
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Family Caregiving in Mental Illness
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Pluripotent Stem Cells Research
- Cancer, Hypoxia, and Metabolism
- Natural product bioactivities and synthesis
- HIV-related health complications and treatments
- Histone Deacetylase Inhibitors Research
Shanghai Public Health Clinical Center
2015-2025
Fudan University
2014-2024
Zhengzhou University
2023
Jilin Medical University
2014-2023
Huadong Hospital
2022
University of Houston
2017-2020
Indo-American Center
2019
University of Illinois Chicago
2019
Yale University
2016
University of Washington
2016
Metastasis leads to poor prognosis in colorectal cancer patients, and there is a growing need for new therapeutic targets. TMEM16A (ANO1, DOG1 or TAOS2) has recently been identified as calcium-activated chloride channel (CaCC) reported be overexpressed several malignancies; however, its expression function (CRC) remains unclear. In this study, we found of mRNA protein high-metastatic-potential SW620, HCT116 LS174T cells, but not primary HCT8 SW480 using RT-PCR, western blotting...
Signal transducer and activator of transcription 3 (STAT3) constitutively expresses in human liver cancer cells has been implicated apoptosis resistance tumorigenesis. Alantolactone, a sesquiterpene lactone, shown to possess anticancer activities various cell lines. In our previous report, we showed that alantolactone induced U87 glioblastoma via GSH depletion ROS generation. However, the molecular mechanism remained unexplored. The present study was conducted envisage alantolactone-induced...
Both siRNA and miRNA can serve as powerful gene-silencing reagents but their specific delivery to cancer cells in vivo without collateral damage healthy remains challenging. We report here the application of RNA nanotechnology for efficient anti-miRNA seed-targeting sequence block growth prostate mouse models. Utilizing thermodynamically ultra-stable three-way junction pRNA phi29 DNA packaging motor, nanoparticles were constructed by bottom-up self-assembly containing anti-prostate-specific...
Hand, foot and mouth disease (HFMD) is a common pediatric illness mainly caused by infection with enterovirus 71 (EV71) coxsackievirus A16 (CA16). The frequent HFMD outbreaks have become serious public health problem. Currently, no vaccine or antiviral drug for EV71/CA16 infections has been approved. In this study, two-step screening platform consisting of reporter virus-based assays cell viability‑based was developed to identify potential inhibitors infection. Two types viruses, pseudovirus...
The purpose of this study was to identify fecal bacterial microbiome changes in patients with chronic human immunodeficiency virus (HIV) infection China. Bacterial 16S rRNA genes were amplified, sequenced (454 pyrosequencing), and clustered into operational taxonomic units using the QIIME software. Relative abundance at phylum genus levels calculated. Alpha diversity determined by Chao 1 observed-species indices, beta double principal component analysis estimated phylogeny-based unweighted...
Antiretroviral therapy (ART) is transforming human immunodeficiency virus (HIV) infection into a chronic condition, leading to an altered disease spectrum in patients. The risk of cardiovascular (CVD) HIV-infected individuals are twice that the general population. This study demonstrates elevated among HIV findings reveal traditional CVD factors prevalent people living with but remain inadequately addressed clinical practice. These underscore both necessity and urgency implementing...
The class I selective inhibitor of the histone deacetylases, mocetinostat, has promising antitumor activities in both preclinical studies and clinical trials. To understand how mocetinostat induces apoptosis, we examined effects on miR-31, a proapoptotic microRNA that was previously found to be epigenetically silenced prostate cancer. We miR-31 significantly upregulated by cancer cells. Antiapoptotic protein E2F6, target decreased treatment. When blocked with an inhibitor, ability induce...
People living with HIV/AIDS (PLWHA) in China experience significant psychological distress, due to high rates of stigma and low availability mental health resources. Recently diagnosed Chinese PLWHA who are men have sex (MSM) particularly vulnerable facing both HIV sexual orientation stigma. Reducing distress enhancing resilience is critical promoting wellbeing. However, no research date has examined evidence-based interventions reduce symptoms improve this population. Based on qualitative...
TMEM16A, a calcium-activated chloride channel (CaCC), is highly amplified and expressed in human cancers involved the growth metastasis of some malignancies. Inhibition TMEM16A represents novel pharmaceutical approach for treatment metastases. The purpose this study to identify new inhibitor, investigate effects inhibitor on proliferation TMEM16A-amplified SW620 cells, elucidate underlying molecular mechanism vitro. We identified small-molecule dehydroandrographolide (DP). By using patch...
Background Understanding the mechanisms of drug resistance can facilitate better management antiretroviral therapy, helping to prevent transmission and decrease morbidity mortality people living with HIV/AIDS. However, there is little data about transmitted acquired for HIV/AIDS patients in Shanghai. Methods A retrospective cohort study HIV-infected who visited Department Infectious Disease from June 2008 2015 was conducted Shanghai, China. Logistic regression analysis performed analyze risk...
Cytochrome P450 enzyme CYP3A4 is an important drug-metabolizing enzyme, and high levels of tumoral expression are linked to drug resistance. We investigated the function vitamin D-regulated miR-627 in intratumoral suppression its role enhancing efficacy chemotherapy. found that targets suppresses colon cancer cell lines. Furthermore, calcitriol (the active form D) suppressed by activating miR-627. As a result, inhibited CYP3A4-mediated metabolism irinotecan (a topoisomerase I inhibitor)...
To understand COVID patients' experiences of and perspectives on disclosure their illness to explore describe the factors affecting decisions among patients in China. Disease is a critical component prevention control virus outbreak, this especially true during COVID-19 pandemic. Understanding could play vital role management. A qualitative study. semi-structured interview guide was used conduct in-depth interviews from April June 2020. All were audio-recorded transcribed, then, thematic...
Background: Nanocomposite Hydrogels (NHs) are 3D molecular networks formed by physically or covalently crosslinking polymer with nanoparticles nanostructures, which particularly suitable for serving as carriers drug delivery systems. Many articles pertaining to the applications of have been published, however, use bibliometric and visualized analysis in this area remains unstudied. The purpose study intended comprehensively analyze knowledge domain, research hotspots frontiers associated...
Calcium-dependent chloride conductances have been described in chicken and human granulosa cells (GCs) may be involved steroidogenesis. However, the molecular identities of corresponding channels remain unknown. The purpose this study was to explore expression function Anoctamin 1 (ANO1) calcium-activated channel (CaCC) mouse ovary. ANO1 mRNA protein identified ovary GCs by RT-PCR, immunoblot, immunostaining. Patch-clamp analysis on freshly isolated an outwardly rectifying Ca(2+)-activated...
Gut microbiota dysbiosis, which has been linked to many neurological diseases, is common in HIV infection. However, its role the pathogenesis of neurocognitive impairment still not established. In this study, a total 85 infected subjects, naïve antiretroviral therapy, were classified into two groups-those with HIV-associated diseases (HAND) and those without, using Montreal Cognitive Assessment (MoCA) test. Fecal samples collected from all subjects analyzed by 16S rRNA amplicon sequencing....