A5101591279- Optical Network Technologies
- Advanced Optical Network Technologies
- RNA Interference and Gene Delivery
- Advanced Photonic Communication Systems
- Hydrocarbon exploration and reservoir analysis
- Software-Defined Networks and 5G
- Advanced biosensing and bioanalysis techniques
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Photonic and Optical Devices
- Epilepsy research and treatment
- Bacteriophages and microbial interactions
- Axon Guidance and Neuronal Signaling
- Semiconductor Lasers and Optical Devices
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Anesthesia and Sedative Agents
- RNA and protein synthesis mechanisms
- Neurological Disease Mechanisms and Treatments
- Cloud Computing and Resource Management
- RNA modifications and cancer
- Botulinum Toxin and Related Neurological Disorders
- Neurogenesis and neuroplasticity mechanisms
- Interconnection Networks and Systems
Chongqing Medical University
2017-2024
Children's Hospital of Chongqing Medical University
2017-2024
National Clinical Research
2024
Molecular Oncology (United States)
2017-2024
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
University of Chicago Medical Center
2017-2024
Institute of Electrical and Electronics Engineers
2024
Oxford Instruments (United Kingdom)
2018-2023
Second Xiangya Hospital of Central South University
2016-2022
Background Neuroapoptosis is induced by the administration of anesthetic agents to young. As alpha2 adrenoceptor signaling plays a trophic role during development and neuroprotective in several settings neuronal injury, authors investigated whether dexmedetomidine could provide functional protection against isoflurane-induced injury. Methods Isoflurane-induced injury was provoked organotypic hippocampal slice cultures vitro or vivo postnatal day 7 rats 6-h exposure 0.75% isoflurane with...
Background Anesthetics, including isoflurane and nitrous oxide, an antagonist of the N-methyl-D-aspartate subtype glutamate receptor, have been demonstrated to induce apoptotic neurodegeneration when administered during neurodevelopment. Xenon, also antagonist, not only lacks characteristic toxicity produced by other antagonists, but attenuates neurotoxicity this class agent. Therefore, current study sought investigate xenon's putative protective properties against anesthetic-induced...
One of the advantages nanotechnology is feasibility to construct therapeutic particles carrying multiple therapeutics with defined structure and stoichiometry. The field RNA emerging. However, controlled assembly stable nanoparticles functionalities which retain their original role challenging due refolding after fusion. Herein, we report construction thermodynamically X-shaped carry four motifs by self-assembly reengineered small fragments. We proved that each arm helices in X-motif can...
Both DNA and RNA can serve as powerful building blocks for bottom-up fabrication of nanostructures. A pioneering concept proposed by Ned Seeman 30 years ago has led to an explosion knowledge in nanotechnology. be manipulated with simplicity characteristic DNA, while possessing noncanonical base-pairing, versatile function, catalytic activity similar proteins. However, standing awe the sensitivity RNase degradation made many scientists flinch away from Here we report construction stable...
Mesenchymal stem cells (MSCs) are multipotent progenitor that can undergo self-renewal and differentiate into multiple lineages. Osteogenic differentiation from MSCs is a well-orchestrated process regulated by signaling pathways. We previously demonstrated BMP9 one of the most potent osteogenic factors. However, molecular mechanism through which governs osteoblastic remains to be fully understood. Increasing evidence indicates noncoding RNAs (ncRNAs) may play important regulatory roles in...
The bacteriophage phi29 DNA packaging motor, one of the strongest biological motors characterized to date, is geared by a RNA (pRNA) ring. When assembled from three fragments, its three-way junction (3WJ) motif highly thermostable, resistant 8 M urea, and remains associated at extremely low concentrations in vitro vivo. To elucidate structural basis for unusual stability, we solved crystal structure this pRNA 3WJ 3.05 Å. revealed two divalent metal ions that coordinate 4 nt fragments....
Both siRNA and miRNA can serve as powerful gene-silencing reagents but their specific delivery to cancer cells in vivo without collateral damage healthy remains challenging. We report here the application of RNA nanotechnology for efficient anti-miRNA seed-targeting sequence block growth prostate mouse models. Utilizing thermodynamically ultra-stable three-way junction pRNA phi29 DNA packaging motor, nanoparticles were constructed by bottom-up self-assembly containing anti-prostate-specific...
Administration of certain general anesthetics to rodents during the synaptogenic phase neurodevelopment produces neuronal injury. Preconditioning (pretreatment) can reduce tissue injury caused by a severe insult; authors investigated whether pretreatment strategies protect developing brain from anesthetic-induced neurotoxicity.Seven-day-old Sprague-Dawley rats were pretreated with one following: 70% xenon, nitrous oxide, or 8% hypoxia for 2 h; 24 h later, exposed neurotoxic combination oxide...
We present results from the first demonstration of a fully integrated SDN-controlled bandwidth-flexible and programmable SDM optical network utilizing sliceable self-homodyne spatial superchannels to support dynamic bandwidth QoT provisioning, infrastructure slicing isolation. Results show that SDN is suitable control plane solution for high-capacity flexible network. It able provision end-to-end requests according user requirements, considering unique characteristics underlying infrastructure.
Mesenchymal stem cells (MSCs) are multipotent non-hematopoietic progenitor that can undergo self-renewal and differentiate into multi-lineages. Bone marrow stromal (BMSCs) represent one of the most commonly-used MSCs. In order to overcome technical challenge maintaining primary BMSCs in long-term culture, here we seek establish reversibly immortalized mouse (imBMSCs). By exploiting CRISPR/Cas9-based homology-directed-repair (HDR) mechanism, target SV40T Rosa26 locus efficiently immortalize...
Effective bone tissue engineering is important to overcome the unmet clinical challenges as more than 1.6 million grafts are done annually in United States. Successful needs minimally three critical constituents: osteoprogenitor cells, osteogenic factors, and osteoinductive/osteoconductive scaffolds. Osteogenic progenitors derived from multipotent mesenchymal stem cells (MSCs), which can be prepared numerous sources, including adipose tissue. We previously showed that BMP9 most BMP induces...
Chronic cerebral hypoperfusion (CCH) is a common pathophysiological state that usually occurs in conditions such as vascular dementia and Alzheimer's disease, both of which are characterized by cognitive impairment. In previous studies we found learning capacity memory were gradually impaired with CCH, altered the expression synaptophysin, microtubule associated protein-2, growth protein-43, brain-derived neurotrophic factor, nerve N-methyl-D-aspartate receptor subunit 1, cAMP response...
This paper reports all-optical, function programmable, transparent, intra- and inter-data center networking (DCN) using space time-division multiplexing (SDM/TDM) within data centers wavelength division (WDM) between centers. A multielement fiber is used for SDM transmission to provide a large quantity of optical links the top-of-racks (ToRs) programmable cluster switch. Beam-steering large-port-count switches, as central switches intercluster switch, single hop circuit switching solution,...
Exposure to anesthetics triggers apoptotic neurodegeneration in the neonatal rat brain; whether neuronal apoptosis also occurs spinal cord, a crucial target for analgesic and anesthetic drugs, is unknown.We exposed 7-day-old rats were air or 75% nitrous oxide + 0.75% isoflurane oxygen 6 h (n = 19 per group). Caspase-3 immunoreactivity was evaluated lumbar cord at end of gas exposure 3 Developmental nociceptive responses tested using tail flick latencies on postnatal days 8, 15, 30 Motor...
Ovarian cancer is a highly metastatic and lethal disease, making it imperative to find treatments that target late-stage malignant tumors. The packaging RNA (pRNA) of bacteriophage phi29 DNA-packaging motor has been reported function as versatile vehicle carry small interference (siRNA) for silencing survivin. In this article, we explore the potential pRNA siRNA specifically targeted metallothionein-IIa (MT-IIA) messenger (mRNA), compare survivin targeting pRNA. These two anti-apoptotic cell...
Diabetes in the elderly increases cognitive impairment, but underlying mechanisms are still far from fully understood. A non-targeted metabolomics approach based on liquid chromatography-mass spectrometry (LC-MS) was performed to screen out serum biomarkers of diabetic mild impairment (DMMCI) rats. Total 48 SD rats were divided into three groups, Normal control (NC) group, high-fat diet (HFD) fed group and type 2 diabetes mellitus (T2DM) group. The T2DM rat model induced by intraperitoneal...
The 117-nucleotide (nt) RNA, called the packaging RNA (pRNA) of bacteriophage phi29 DNA motor, has been shown to be an efficient vector for construction nanoparticles delivery small interfering (siRNA) into specific cancer or viral-infected cells. Currently, chemical synthesis 117-nt is not feasible commercially. In addition, labeling at locations on pRNA requires understanding its modular organization. Here, we report multiple approaches a functional 117-base using two synthetic fragments...
A multidomain and multitechnology optical network orchestration is demonstrated in an international testbed located Japan, the U.K., Spain. The application-based operations architecture proposed as a carrier software-defined solution for provisioning end-to-end transport services through scenario, consisting of 46-108 Gb/s variable-capacity OpenFlow-capable packet switching programmable, flexi-grid elastic path network.
This paper reports an FPGA-based switch and interface card (SIC) its application scenario in all-optical, programmable disaggregated data center network (DCN). Our novel SIC is designed implemented to replace traditional optical cards, plugged into the server directly, supporting packet switching (OPS)/optical circuit (OCS) or time division multiplexing (TDM)/wavelength (WDM) traffic on demand. Placing each server/blade, we eliminate electronics from top of rack (ToR) by pushing all...