A5071460486- Tissue Engineering and Regenerative Medicine
- Transplantation: Methods and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Electrospun Nanofibers in Biomedical Applications
- Organ Transplantation Techniques and Outcomes
- Congenital heart defects research
- Cardiac Valve Diseases and Treatments
- Airway Management and Intubation Techniques
- Renal Transplantation Outcomes and Treatments
- Pluripotent Stem Cells Research
- Family and Patient Care in Intensive Care Units
- Pulmonary Hypertension Research and Treatments
- Organ Donation and Transplantation
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Structural Anomalies and Repair
- SARS-CoV-2 detection and testing
- Cardiac pacing and defibrillation studies
- Anesthesia and Sedative Agents
- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
- Patient Safety and Medication Errors
- Cardiac Arrest and Resuscitation
University of Cambridge
2019-2024
Royal Victoria Hospital
2024
University of Ulster
2024
Papworth Hospital
2016-2024
Addenbrooke's Hospital
2021-2023
Wellcome/MRC Cambridge Stem Cell Institute
2019-2023
James Cook University Hospital
2023
Freeman Hospital
2014-2016
Background Anesthetics, including isoflurane and nitrous oxide, an antagonist of the N-methyl-D-aspartate subtype glutamate receptor, have been demonstrated to induce apoptotic neurodegeneration when administered during neurodevelopment. Xenon, also antagonist, not only lacks characteristic toxicity produced by other antagonists, but attenuates neurotoxicity this class agent. Therefore, current study sought investigate xenon's putative protective properties against anesthetic-induced...
COVID-19 patients often develop severe cardiovascular complications, but it remains unclear if these are caused directly by viral infection or secondary to a systemic response. Here, we examine the cardiac tropism of SARS-CoV-2 in human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and smooth muscle cells (hPSC-SMCs). We find that selectively infects hPSC-CMs through receptor ACE2, whereas hPSC-SMCs there is minimal entry replication. After into cardiomyocytes, assembled...
Ischemic heart failure is due to irreversible loss of cardiomyocytes. Preclinical studies showed that human pluripotent stem cell (hPSC)-derived cardiomyocytes could remuscularize infarcted hearts and improve cardiac function. However, these remained immature. Incorporating hPSC-derived epicardial cells has been shown cardiomyocyte maturation, but the exact mechanisms are unknown. We posited fibronectin (FN1) as a mediator epicardial-cardiomyocyte crosstalk assessed its role in driving...
Blood transfusion is associated with higher morbidity and mortality after general cardiothoracic surgery but its impact within the transplant population unclear. We investigated profile of blood product in bilateral lung on function mortality.Three hundred eleven adult patients who underwent between 2003 2013 were retrospectively reviewed. Patients stratified according to pretransplant diagnoses amount products transfused 24 h transplant. All-cause at 1-year follow-up was analysed using a...
Risks of cardiac surgery in patients with poor [ejection fraction (EF) ≤ 30%] and very left ventricular (LV) function (EF 20%) may be considered high due to increased mortality. We examine our results this cohort patients.Data were prospectively collected retrospectively analysed from 4491 consecutive referred for over 18 years (July 1993-June 2012). Univariate predictors in-hospital postoperative mortality by the appropriate tests. Variables P < 0.1 entered into multivariable...
Objectives: Blood transfusion is associated with higher morbidity and mortality after general cardiothoracic surgery but little known of the impact on transplant population. We investigated profile blood product in bilateral lung (BLT) population function survival outcomes. Methods: A total 311 adult patients who underwent BLT between 2003 2013 were retrospectively reviewed. Patients stratified according to pretransplant diagnosis amount products transfused within 24 h surgery. Results:...
BackgroundSecondary mitral regurgitation (MR) is common in heart failure with reduced ejection fraction (HFrEF) and associated poor outcomes. However, there little evidence regarding secondary MR advanced HFrEF. Poor outcomes for intervention suggest a need further risk stratification.ObjectivesWe hypothesized adverse prognosis right ventricles (RV) less able to compensate increased pulmonary pressures of post-capillary cause the context MR.MethodsPatients were assessed echocardiography,...
Abstract Objectives Surgical distractions are associated with worse patient outcomes. Lung transplantation and cardiac surgery’s multi-disciplinary nature, their inherent complexities render them more vulnerable to distractions. We aim use a novel capture tool evaluate the severity of during surgery (CS) lung (LTx) assess its impact on post-operative complications. Methods A prospective ‘blinded’ study was undertaken by direct observation CS LTx. Events were identified using Imperial College...
Ischaemic heart failure is due to the irreversible loss of cardiomyocytes. Preclinical studies showed that human pluripotent stem cell (hPSC)-derived cardiomyocytes could regenerate infarcted hearts and improve cardiac function. However, these hPSC-derived remained immature. Epicardial-myocardial crosstalk underpins key events during development maturation. Recently we incorporating epicardial cells improved cardiomyocyte maturation in 3D-engineered tissues (3D-EHTs). signaling pathways...
Objectives: Emerging evidence suggests that erythropoietin (EPO) protects the heart from ischemic injury and promotes beneficial remodelling. The role of EPO its receptor (EPO-R) in cardiac regeneration remains unclear. We aimed to investigate cardio-protective effects stem cell homing, proliferation angiogenesis modulated by EPO.
<h3>Background</h3> Heart failure remains to be one of the major causes morbidity and mortality post-myocardial infarction. Current therapeutic strategies are aimed at minimising progression, but apart from cardiac transplantation, no treatment thus far has addressed loss contractile tissue post-injury. Transplantation human embryonic stem cell-derived cardiomyocytes (hESC-CMs) emerged as a promising strategy address this issue, these treatments remain inefficient. hESC- epicardium...
Background: Human embryonic stem cell-derived epicardium (hESC-Epis) has been shown to improve the function of hESC-derived cardiomyocytes (hESC-CM) in vitro and post-transplantation into animal myocardial infarction models. However, underlying mechanisms mediating these effects remain poorly characterised. Bulk RNA sequencing hESC-Epis suggests a role for genes related extracellular matrix remodeling effects, with fibronectin (FN1) being highly implicated. Study Objective: To examine FN1...