A5076242313- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Tissue Engineering and Regenerative Medicine
- ECG Monitoring and Analysis
- Pluripotent Stem Cells Research
- Electrospun Nanofibers in Biomedical Applications
- Respiratory Support and Mechanisms
- Time Series Analysis and Forecasting
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare Technology and Patient Monitoring
- Congenital heart defects research
- Cardiac electrophysiology and arrhythmias
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Earthquake Detection and Analysis
- Wnt/β-catenin signaling in development and cancer
- Traumatic Brain Injury Research
- 3D Printing in Biomedical Research
- Anesthesia and Sedative Agents
- Developmental Biology and Gene Regulation
- Optical Imaging and Spectroscopy Techniques
- Acute Ischemic Stroke Management
Wayne State University
2025
University of Washington
2016-2024
Center for American Progress
2021
Harborview Medical Center
2021
Seattle Indian Health Board
2020
Bellevue Hospital Center
2020
Resuscitation Council
2020
Progress (Ireland)
2020
Seattle University
2017-2019
Kaiser Permanente
2018
ABSTRACT The γ‐protocadherins (γ‐Pcdhs) comprise 22 homophilic cell adhesion molecule isoforms, expressed from the Pcdhg gene cluster via promoter choice mechanisms that serve many crucial functions during neural development. Emerging evidence supports hypothesis distinct isoforms have unique functions. γC4 isoform, which is Pcdhgc4 and includes its variable exon, sole γ‐Pcdh isoform essential for postnatal survival in mice. Here we describe a new mouse line ( C4‐GFP ) with C‐terminal GFP...
Engineered heart tissues made from human pluripotent stem cell-derived cardiomyocytes have been used for modeling cardiac pathologies, screening new therapeutics, and providing replacement tissue. Current methods measure the functional performance of engineered tissue by their twitch force beating frequency, typically obtained optical measurements. In this article, we describe a novel method assessing frequency using magnetic field sensing, which enables multiple to be measured...
<title>Abstract</title> Developmental apoptosis is an important mechanism for the formation of functional neural circuits. Distinct neuronal subtypes undergo to a greater or lesser extent during development, although how this regulated at cell type level unknown. The clustered Protocadherins (cPcdhs) are ~ 60 homophilic adhesion molecules expressed from three contiguous gene clusters, which together encode a-, b-, and g-Pcdh families. Only one cPcdh isoform, gC4, essential survival in mouse,...
Current resuscitation protocols require pausing chest compressions during cardiopulmonary (CPR) to check for a pulse. However, CPR when patient is pulseless can worsen outcomes. Our objective was design and evaluate an ECG-based algorithm that predicts pulse presence with or without CPR. We evaluated 383 patients being treated out-of-hospital cardiac arrest real-time ECG, impedance audio recordings. Paired ECG segments having organized rhythm immediately preceding (during CPR) the (without...
Background and Purpose— Large artery occlusion (LAO) in ischemic stroke requires recognition triage to an endovascular treatment center. Noninvasive LAO detection is needed improve triage. Methods— Prospective study test whether noninvasive cerebral oximetry can detect anterior circulation acute stroke. Interhemispheric ΔBrSO 2 was compared with controls. Results— In stroke, mean interhemispheric −8.3±5.8% (n=19), 0.4±5.8% small (n=17), 0.4±6.0% hemorrhagic (n=14), 0.2±7.5% subjects without...
Background: Refractory ventricular fibrillation (R-VF) patients, defined as requiring ≥ 3 shocks during resuscitation of OHCA, have relatively poor outcomes. Prior studies predicted R-VF using the ECG, suggesting potential to guide early patient-specific treatment for R-VF. However, comprises multiple phenotypes with distinct defibrillation response profiles: Incessant VF (no terminate VF), recurrent (all but recurs), or mixed (shocks variably VF). These may prognoses, and also respond...
Introduction: Chest compressions during CPR cause oscillations in capnography waveforms. The airway opening index (AOI) was proposed to measure the amplitude of these oscillations. Studies indicate that AOI is inversely correlated with change intrathoracic pressure and lower values may reflect closure. However, little has been reported about how different waveform approach affect appearance or Aim: Quantify differences obtained from mainstream sidestream capnography. Methods: We...
1216 Anticoagulation in atrial fibrillation / Cardiac regeneration and disease modelling with induced Pluripotent Stem Cells (iPSC) characteristics treatment apixaban is associated lower risk of stroke/SE MBs than rivaroxaban, similar outcomes compared dabigatran among elderly NVAF patients the US.Head-to-head trials are needed to fully understand comparative efficacy safety different DOACs.
Objective: Current resuscitation protocols require pausing chest compressions during cardiopulmonary (CPR) to check for a pulse. However, CPR pulseless rhythm can worsen patient outcome. Our objective is design an ECG-based algorithm that predicts pulse status uninterrupted and evaluate its performance. Methods: We evaluated 383 patients being treated out-of-hospital cardiac arrest using defibrillator data. collected paired immediately adjacent ECG segments having organized rhythm. Segments...
Introduction: Chest compressions (CCs) during CPR cause electrical artifacts in the ECG. Prior work has found that severity of CC artifact, quantified by signal-to-noise ratio (SNR), affects diagnostic sensitivity defibrillator algorithms designed to detect shockable rhythms CCs. Whether SNR is altered defibrillation unknown. We therefore compared before and after shocks. Methods: evaluated patients with out-of-hospital cardiac arrest who received at least 1 shock, had subsequent ventricular...
Purpose: Most endoscopic procedures in the United States(US) are performed using endoscopist- directed benzodiazepines and opioid administration. More recently, deep sedation with Propofol has been used US but is generally managed by anaesthesiologists. Compared to conscious sedation, associated lower or comparable rates of adverse events, higher post-procedure patient satisfaction, faster recovery time. Professional societies have released position statements endorsing administration...
Objective: Currently, cardiac arrest resuscitation requires interruptions in CPR every 2 minutes to assess rhythm and pulse. A method which analyzed the ECG during predict whether or not an organized generated a pulse could help direct care limit interruptions. We evaluated real-time status from segments with without CPR. Methods: The study cohort received attempted by metropolitan EMS system following out-of-hospital ventricular fibrillation arrest. Two-minute rhythm/pulse checks on...
Background: Current resuscitation protocols require pausing cardiopulmonary (CPR) to check for a pulse. However, CPR during pulseless rhythm worsens patient outcome. We designed an ECG-based algorithm that predicts pulse status uninterrupted CPR, and evaluated its performance both with without CPR. Methods: 383 patients who were treated out-of-hospital cardiac arrest using defibrillators real-time ECG, audio recordings. collected paired adjacent ECG segments organized rhythms. Segments the...
Background: Resuscitation from out-of-hospital cardiac arrest (OHCA) due to ventricular fibrillation (VF) typically involves continuous CPR cycles interrupted every 2 minutes for rhythm analysis and potential defibrillation. Quantitative measures of the VF ECG waveform have been proposed guide therapy because they are associated with myocardial energetics, dynamic over course resuscitation, predict outcome. However, while until recently required interruption accurately gauge prognostic...