A5046215274- Cardiac and Coronary Surgery Techniques
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Tissue Engineering and Regenerative Medicine
- Cardiac Ischemia and Reperfusion
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Hemodynamic Monitoring and Therapy
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Intensive Care Unit Cognitive Disorders
Universität Ulm
2012-2025
University Hospital Ulm
2015-2024
Leipzig Heart Institute
2017
University of Rostock
2004-2013
University Hospital Augsburg
2013
University Medical Center
2013
Fraunhofer Institute for Integrated Systems and Device Technology
2011
University of Regensburg
1994-2009
University Hospital Regensburg
1998-2009
Park Terrace Care Center
2007
Abstract Although studies in vivo revealed promising results bone regeneration after implantation of scaffolds together with osteogenic progenitor cells, basic questions remain how material surfaces control the biology mesenchymal stem cells (MSC). We used human MSC derived from marrow and studied differentiation on calcium phosphate surfaces. In medium differentiated to osteoblasts hydroxyapatite BONITmatrix ® , a degradable xerogel composite, within 14 days. Cells higher alkaline...
Abstract: It has been suggested that the morbidity associated with cardiopulmonary bypass can be attributed in part to blood–material and blood–air interactions extracorporeal circulation (ECC). A recently introduced minimized ECC‐system (MECC System) should able reduce these negative effects ECC. retrospective analysis was performed comprising 485 patients who were operated on for elective coronary artery grafting (CABG) using MECC System intermittent antegrade warm blood cardioplegia...
The use of cardiopulmonary bypass (CPB) in cardiothoracic surgery results a well-known activation the immunologic response. In some cases, however, this triggered response may be excessive, leading to severe systemic inflammatory syndrome (SIRS) and induced organ dysfunction. For example, patients frequently develop hemodynamic instability with hypotension low vascular resistance. To date, different therapeutic approaches, such as steroids, have been tried control maladaptive postoperative...
Introduction Infective endocarditis is a serious disease condition. Depending on the causative microorganism and clinical symptoms, cardiac surgery valve replacement may be needed, posing additional risks to patients who simultaneously suffer from septic shock. The combination of bacterial spreadout artificial cardiopulmonary bypass (CPB) surfaces results in release key inflammatory mediators leading an overshooting systemic hyperinflammatory state frequently associated with compromised...
<h3>Importance</h3> Delirium significantly worsens elective surgery outcomes and costs. risk is highest in elderly populations, whose surgical health care resource consumption (50%) exceeds their demographic proportion (15% to 18%) high-resource countries. Effective nonpharmacologic delirium prevention could safely improve these vulnerable patients, but data from procedure-specific studies are insufficiently compelling drive changes practice. approaches applicable different settings remain...
Introduction The trial hypothesized that minimally invasive extra-corporeal circulation (MiECC) reduces the risk of serious adverse events (SAEs) after cardiac surgery operations requiring without circulatory arrest. Methods This is a multicentre, international randomized controlled across fourteen centres including patients aged ≥18 and <85 years undergoing elective or urgent isolated coronary artery bypass grafting (CABG), aortic valve replacement (AVR) surgery, CABG + AVR surgery....
The functional impact and cellular context of mosaic structural variants (mSVs) in normal tissues is understudied. Utilizing Strand-seq, we sequenced 1,133 single-cell genomes from 19 human donors increasing age, discovered the heterogeneous mSV landscapes hematopoietic stem progenitor cells. While mSVs are continuously acquired throughout life, expanded subclones our cohort confined to individuals >60. Cells already harboring more likely acquire additional somatic variants, including...
A 45-year-old male was admitted to our hospital with a small bowel obstruction due torsion and immediately scheduled for surgical intervention. At anesthesia induction, the patient aspirated subsequently developed severe SIRS ARDS multiple organ failure requiring use of ECMO, CRRT, antibiotics, low dose steroids. Due rapid deterioration in clinical status concurrent surge inflammatory biomarkers, an extracorporeal cytokine adsorber (CytoSorb) added CRRT blood circuit. The combined treatment...
In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSC). We report increased frequencies HSC, progenitor and lineage negative in the elderly but a decreased frequency multi-lymphoid progenitors. Aged HSC further exhibited delay initiating division ex vivo though without changes their kinetics. The activity small RhoGTPase Cdc42 was elevated aged identified positive correlation between upon aging. polar for polarity proteins was, similar to mouse, aging,...
Intraoperative antithrombotic drug removal by haemoadsorption is a novel strategy to reduce perioperative bleeding in patients on drugs undergoing cardiac surgery. The international STAR registry reports real-world clinical outcomes associated with this application. All underwent surgery before completing the recommended washout period. device was incorporated into cardiopulmonary bypass (CPB) circuit. Patients P2Y
Patients on direct-acting oral anticoagulants (DOACs) are at high risk of perioperative bleeding complications. Intraoperative hemoadsorption is a novel strategy to reduce in patients DOACs undergoing non-deferable cardiac surgery. The international STAR-registry reports real-world clinical outcomes associated with this application. device was incorporated into the cardiopulmonary bypass (CPB) circuit and active for duration pump run. CABG and/or single valve surgery before completing...
Coronary artery fistulas (CAFs) are a rare congenital heart disease. Large can lead to coronary steal phenomena presenting with angina, failure, and in cases, cardiogenic shock. A 55-year-old woman acutely presented at our center nonhemorrhagic pericardial tamponade large CAF of an aneurysmatic right the sinus was diagnosed. Pericardiocentesis used for initial hemodynamic stabilization. On cardiopulmonary bypass, perforations connecting were closed via suture. In cases CAF, shock is usually...
Cardiac surgery and the associated ischemia-reperfusion injury trigger an inflammatory response, which, in turn, can contribute to organ damage, prolonged hospitalization, mortality. Therefore, present study performed comprehensive monitoring of neutrophil-related inflammation patients who underwent aortic valve surgery, including extracorporeal circulation. Neutrophil-related inflammation, as well alterations cellular physiology, phenotype, function, were analyzed by flow cytometry, ELISA,...
Long-term extracorporeal lung assist is limited by a significant mechanical blood trauma resulting in bleeding and hemolysis. To reduce the drawbacks of new technique has been developed, which driving force for circuit derives from patients arterio-venous pressure gradient (pumpless assist). The aim this clinical study was to test feasibilty effectiveness pumpless with acute respiratory distress syndrome.Twenty (41+/-16 years) syndrome various causes failing respirator therapy were enrolled....
Transplantation of mesenchymal stem cells (MSCs) derived from adult bone marrow has been proposed as a potential therapeutic approach for post-infarction left ventricular (LV) dysfunction. However, age-related functional decline restricted their clinical benefits after transplantation into the infarcted myocardium. The limitations imposed on patient could be addressed by genetic modification cells. This study was designed to improve our understanding human (hMSCs) polyethylenimine (PEI,...
Objective: Proinflammatory cytokines, such as interleukin-6 (IL-6), and soluble adhesion molecules, E-selectin, may play an important role in patient response to cardiopulmonary bypass (CPB). We sought define whether the heart lungs serve sources of these inflammatory mediators under clinical conditions myocardial revascularization using CPB cardioplegic arrest. Methods: Plasma levels IL-6 E-selectin were measured coronary sinus (CS), arterial, pulmonary arterial (PA) left atrial (LA) blood...