A5074710678- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Advanced X-ray and CT Imaging
- Viral Infections and Immunology Research
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- IgG4-Related and Inflammatory Diseases
- Cardiovascular Disease and Adiposity
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lanthanide and Transition Metal Complexes
- Neuroendocrine Tumor Research Advances
- Chemotherapy-induced cardiotoxicity and mitigation
- Ultrasound in Clinical Applications
- Cardiac tumors and thrombi
- Medical Imaging Techniques and Applications
- Metabolism and Genetic Disorders
- Pericarditis and Cardiac Tamponade
The University of Queensland
2015-2025
John Radcliffe Hospital
2019-2024
University of Oxford
2020-2024
Coventry University
2024
Royal Victoria Hospital
2022-2024
University of Ulster
2022-2024
Papworth Hospital
2022-2024
Oxford BioMedica (United Kingdom)
2021-2024
Queensland Health
2023
Resonance Research (United States)
2020-2022
Background Echocardiographic global longitudinal strain (GLS) is increasingly recognised as a more effective technique than conventional ejection fraction (EF) in detecting subtle changes left ventricular (LV) function. This study investigated the prognostic value of GLS over EF patients with advanced Chronic Kidney Disease (CKD). Methods The included 183 (57% male, 63% on dialysis) CKD stage 4, 5 and 5Dialysis (D). 112 (61%) died follow up 7.8 ± 4.4 years 41% deaths were due to...
Background: Myocardial scars are assessed noninvasively using cardiovascular magnetic resonance late gadolinium enhancement (LGE) as an imaging gold standard. A contrast-free approach would provide many advantages, including a faster and cheaper scan without contrast-associated problems. Methods: Virtual native (VNE) is novel technology that can produce virtual LGE-like images the need for contrast. VNE combines cine T1 maps to artificial intelligence. was developed patients with previous...
Sinus tachycardia commonly occurs at the start of clozapine treatment, often leading to discontinuation owing perceived adverse cardiovascular effects. However, little evidence exists on its natural course after initiation. We aimed determine frequency and clozapine-induced over first month treatment identify possible risk factors In this cross-sectional study, we serially monitored heart rates (HRs) other clinical variables psychiatric inpatients commencing 28 days. HRs were plotted time...
Transient pulmonary congestion during exercise is emerging as an important determinant of reduced capacity in heart failure with preserved ejection fraction (HFpEF). We sought to determine whether abnormal cardiac energetic state underpins this process.We recruited patients across the spectrum diastolic dysfunction and HFpEF (controls, n=11; type 2 diabetes, n=9; HFpEF, n=14; severe attributable amyloidosis, n=9). Cardiac energetics were measured using phosphorus spectroscopy define...
Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging is the gold standard for noninvasive myocardial tissue characterization but requires intravenous contrast agent administration. It highly desired to develop a agent-free technology replace LGE faster and cheaper CMR scans.
In suspected non-ST-segment-elevation myocardial infarction (NSTEMI), this presumed diagnosis may not hold true in all cases, particularly patients with non-obstructive coronary arteries (NOCA). Additionally, multi-vessel artery disease (MVD), the infarct-related (IRA) be incorrect. To assess diagnostic utility of cardiovascular magnetic resonance (CMR) before invasive angiogram (ICA) NSTEMI. 100 consecutive stable acute NSTEMI (70% male, age 62±11 years) prospectively underwent CMR pre-ICA...
Background The sympathetic cotransmitter, neuropeptide Y (NPY), is released into the coronary sinus during ST-segment-elevation myocardial infarction and can constrict microvasculature. We sought to establish whether peripheral venous (PV) NPY levels, which are easy obtain measure, associated with microvascular obstruction, recovery, prognosis. Methods Results levels were measured immediately after primary percutaneous intervention compared angiographic cardiovascular magnetic resonance...
Acute ST-segment elevation myocardial infarction (STEMI) has effects on the myocardium beyond immediate infarcted territory. However, pathophysiologic changes in noninfarcted and their prognostic implications remain unclear.The purpose of this study was to evaluate long-term value acute both post-STEMI.Patients with STEMI undergoing primary percutaneous coronary intervention underwent evaluation blood biomarkers cardiac magnetic resonance (CMR) at 2 days 6 months, follow-up for major adverse...
BackgroundAdenosine stress T1-mapping on cardiovascular magnetic resonance (CMR) can differentiate between normal, ischemic, infarcted, and remote myocardial tissue classes without the need for contrast agents. Regadenoson, a selective coronary vasodilator, is often used in perfusion imaging when adenosine contra-indicated, has advantages ease of administration, safety profile, clinical workflow. We aimed to characterize regadenoson response healthy individuals, investigate its ability...
Background: Quantitative cardiovascular magnetic resonance (CMR) T1 mapping has shown promise for advanced tissue characterisation in routine clinical practise. However, is prone to motion artefacts, which affects its robustness and interpretation. Current methods correction on are model-driven with no guarantee generalisability, limiting widespread use. In contrast, emerging data-driven deep learning approaches have good performance general image registration tasks. We propose MOCOnet, a...
Background Patients with a history of COVID-19 infection are reported to have cardiac abnormalities on cardiovascular magnetic resonance (CMR) during convalescence. However, it is unclear whether these were present the acute illness and how they may evolve over time. Methods We prospectively recruited unvaccinated patients hospitalized ( n = 23), compared them matched outpatient controls without 19) between May 2020 2021. Only those past disease recruited. performed in-hospital CMR at median...
Abstract Stress and rest T1-mapping may assess for myocardial ischemia extracellular volume (ECV). However, the stress T1 response is method-dependent, underestimation lead to misdiagnosis. Further, ECV quantification be affected by time, as well number dosage of gadolinium (Gd) contrast administered. We compared two commonly available approaches in their measurement stability. Healthy subjects (n = 10, 50% female, 35 ± 8 years) underwent regadenoson CMR (1.5 T) on separate days. Prototype...