Ambra Masi
A5060284908- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Parathyroid Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Neuroendocrine Tumor Research Advances
- Eosinophilic Disorders and Syndromes
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Peptidase Inhibition and Analysis
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Acute Myocardial Infarction Research
- Cardiac tumors and thrombi
- Cardiovascular Disease and Adiposity
- Medical Imaging and Pathology Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Neurological disorders and treatments
- Surgical Simulation and Training
- Systemic Sclerosis and Related Diseases
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2020-2025
The Royal Free Hospital
2022-2024
University College London
2022-2024
University Hospital of Lausanne
2023-2024
University of Lausanne
2024
Ca' Foncello Hospital
2023
John Radcliffe Hospital
2019-2022
University of Oxford
2019-2022
Roland Hill (United Kingdom)
2022
Royal Free London NHS Foundation Trust
2022
Diagnostic and therapeutic advances have led to much greater awareness of transthyretin cardiac amyloidosis (ATTR-CA). We aimed characterize changes in the clinical phenotype patients diagnosed with ATTR-CA over past 20 years. This is a retrospective observational cohort study all referred National Amyloidosis Centre (2002-2021) whom was differential diagnosis. identified 2995 suspected ATTR-CA, 1967 had diagnosis confirmed. Analysis by 5-year periods revealed an incremental increase...
Transthyretin amyloid cardiomyopathy (ATTR-CM) is often assumed to be associated with wild-type TTR genotype (ATTRwt) in elderly patients (aged ≥70), some of whom are not offered genetic testing. We sought estimate the prevalence, clinical characteristics and prognostic implications transthyretin (TTR) variants among diagnosed ATTR-CM.Data from consecutive over 70 years age ATTR-CM at UK National Amyloidosis Centre between January 2010 August 2022 were retrospectively evaluated. All...
Accurate risk stratification for patients with non-dilated left ventricular cardiomyopathy (NDLVC) remains challenging due to lack of dedicated clinical trials. This post-hoc analysis aims delineate the arrhythmic and assess incremental value cardiac magnetic resonance (CMR) imaging in DERIVATE (CarDiac MagnEtic Resonance Primary Prevention Implantable CardioVerter DebrillAtor ThErapy) study cohort meeting NDLVC diagnostic criteria. Patients from registry were identified absence (LV)...
Background Scar burden with late gadolinium enhancement (LGE) cardiac MRI (CMR) predicts arrhythmic events in patients postinfarction single-center studies. However, LGE analysis requires experienced human observers, is time consuming, and introduces variability. Purpose To test whether postinfarct scar CMR can be quantified fully automatically by machines to compare the ability of analyzed humans predict events. Materials Methods This study a retrospective multicenter, multivendor CarDiac...
The aim of this registry was to evaluate the additional prognostic value a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in large cohort consecutive unselected non-ischaemic cardiomyopathy (NICM) patients.In DERIVATE (www.clinicaltrials.gov/registration: RCT#NCT03352648), 1000 (derivation cohort) and 508 (validation NICM patients with chronic heart failure (HF) left ventricular ejection fraction <50% were included. All-cause mortality...
Cardiac amyloid infiltration is the key determinant of survival in systemic light-chain (AL) amyloidosis. Current guidelines recommend early switching therapy patients with a nonoptimal or suboptimal response regardless extent cardiac infiltration.
Aims Transthyretin cardiac amyloidosis (ATTR-CM) is a progressive and fatal cardiomyopathy. Treatment options in patients with advanced ATTR-CM are limited to transplantation (CT). Despite case series demonstrating comparable outcomes CT between non-amyloid cardiomyopathies, considered be contraindication some centers, partly due perceived risk of amyloid recurrence the allograft. We report long-term at two tertiary centers. Materials methods Results retrospectively evaluated across centers...
Cardiovascular involvement in systemic sclerosis (SSc) is heterogeneous and ill-defined. This study aimed to: (i) discover cardiac phenotypes SSc by cardiovascular magnetic resonance (CMR); (ii) provide a CMR-based algorithm for phenotypic classification; (iii) examine associations between mortality.A retrospective, single-centre, observational of 260 patients who underwent clinically indicated CMR including native myocardial T1 T2 mapping from 2016 to 2019 was performed. Agglomerative...
Abstract Purpose To improve the image quality of 3D radial free-running MRI data heart through a deliberate and stepwise extension XD-GRASP reconstruction. Methods Ferumoxytol-enhanced cardiac 3D-radial were reconstructed using an reconstruction improved by 4 new developments: motion-compensated temporal-Total-Variation (MC-tTV) regularization for images, coil-sensitivity, k-space density compensation revisited conjugate-gradient-descent (with exact line search) solving least-square...
Wideband phase-sensitive inversion recovery (PSIR) late gadolinium enhancement (LGE) enables myocardial scar imaging in implantable cardioverter defibrillators (ICD) patients, mitigating hyperintensity artifacts. To address subendocardial visibility challenges, a 2D breath-hold single-shot electrocardiography-triggered black-blood (BB) LGE sequence was integrated with wideband imaging, enhancing scar-blood contrast.
Right ventricular systolic dysfunction (RVSD) is an important determinant of outcomes in heart failure (HF) cohorts. While the quantitative assessment RV function challenging using 2D-echocardiography, cardiac magnetic resonance (CMR) gold standard with its high spatial resolution and precise anatomical definition. We sought to investigate prognostic value CMR-derived a large cohort HF reduced ejection fraction (HFrEF).Study comprised patients enrolled CarDiac MagnEtic Resonance for Primary...
Acute ST-segment elevation myocardial infarction (STEMI) has effects on the myocardium beyond immediate infarcted territory. However, pathophysiologic changes in noninfarcted and their prognostic implications remain unclear.The purpose of this study was to evaluate long-term value acute both post-STEMI.Patients with STEMI undergoing primary percutaneous coronary intervention underwent evaluation blood biomarkers cardiac magnetic resonance (CMR) at 2 days 6 months, follow-up for major adverse...
BackgroundAdenosine stress T1-mapping on cardiovascular magnetic resonance (CMR) can differentiate between normal, ischemic, infarcted, and remote myocardial tissue classes without the need for contrast agents. Regadenoson, a selective coronary vasodilator, is often used in perfusion imaging when adenosine contra-indicated, has advantages ease of administration, safety profile, clinical workflow. We aimed to characterize regadenoson response healthy individuals, investigate its ability...
The purpose of this study was to introduce and evaluate a novel two-dimensional wideband black-blood (BB) LGE sequence, incorporating inversion recovery, T2 preparation, non-rigid motion correction (MOCO) reconstruction, improve myocardial scar detection address artifacts associated with implantable cardioverter defibrillators (ICDs). MOCO free-breathing BB-LGE sequence tested on sheep ischemic in 22 patients cardiac disease, including 15 implants, at 1.5 T. Wideband compared conventional...
Intra-cardiac thrombi can be incidentally found in recurrent melanoma and need careful assessment. An 81-year-old woman, with a history of malignant nasopharyngeal melanoma, was evaluated by echocardiography cardiac magnetic resonance due to the detection undefined masses localized both right atrium ventricle during contrast-enhanced thoraco-abdominal computed tomography.
The year 2023 has been extremely rich in new publications the various subfields of cardiology. Furthermore, European Society Cardiology (ESC) issued revised guidelines focused on management acute coronary syndrome (ACS) and endocarditis, as well an update recommendations for heart failure cardiovascular prevention. most significant updates according to Department CHUV are summarized this review article.