A5025123222- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Advanced MRI Techniques and Applications
- Lysosomal Storage Disorders Research
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Trypanosoma species research and implications
- Cardiac pacing and defibrillation studies
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Congenital Heart Disease Studies
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Studies on Chitinases and Chitosanases
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Inflammatory Biomarkers in Disease Prognosis
- Viral Infections and Immunology Research
- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Neuroendocrine Tumor Research Advances
IRCCS Policlinico San Donato
2017-2024
Ospedale Policlinico San Martino
2023
University of Parma
2023
University College London
2014-2022
The Royal Free Hospital
2015-2022
GTx (United States)
2020
Beth Israel Deaconess Medical Center
2020
National Health Service
2018-2019
Barts Health NHS Trust
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2017
Background— The prognosis and treatment of the 2 main types cardiac amyloidosis, immunoglobulin light chain (AL) transthyretin (ATTR) are substantially influenced by involvement. Cardiovascular magnetic resonance with late gadolinium enhancement (LGE) is a reference standard for diagnosis but its potential stratifying risk unknown. Methods Results— Two hundred fifty prospectively recruited subjects, 122 patients ATTR amyloid, 9 asymptomatic mutation carriers, 119 AL underwent LGE...
Background: Aortic valve replacement (AVR) for aortic stenosis is timed primarily on the development of symptoms, but late surgery can result in irreversible myocardial dysfunction and additional risk. The aim this study was to determine whether presence focal scar preoperatively associated with long-term mortality. Methods: In a longitudinal observational outcome study, survival analysis performed patients severe listed intervention at 6 UK cardiothoracic centers. Patients underwent...
Abstract Aims To assess the ability of cardiovascular magnetic resonance (CMR) to (i) measure changes in response chemotherapy; (ii) correlation between haematological and extracellular volume (ECV); (iii) association ECV prognosis over above existing predictors. Methods results In total, 176 patients with cardiac AL amyloidosis were assessed using serial N-terminal pro-B-type natriuretic peptide (NT-proBNP), echocardiography, free light chains CMR T1 mapping at diagnosis subsequently 6, 12,...
Cardiovascular magnetic resonance (CMR) derived native myocardial T1 is decreased in patients with Fabry disease even before left ventricular hypertrophy (LVH) occurs and may be the first non-invasive measure of myocyte sphingolipid storage. The relationship lowering prior to other candidate early phenotype markers are unknown. Furthermore, reproducibility mapping has never been assessed disease. Sixty-three patients, 34 (54%) female, mean age 48 ± 15 years confirmed (genotyped) underwent...
Background Patients with mitral valve prolapse (MVP) may develop adverse outcomes even in the absence of regurgitation or left ventricular (LV) dysfunction. Purpose To investigate prognostic value annulus disjunction (MAD) and myocardial fibrosis at late gadolinium enhancement (LGE) cardiac MRI patients MVP without moderate-to-severe LV Materials Methods In this longitudinal retrospective study, 118 144 studies were evaluated between October 2007 June 2020 15 European tertiary medical...
The assessment of post-myocardial infarction (MI) left ventricular (LV) remodeling by cardiovascular magnetic resonance (CMR) currently uses criteria defined echocardiography. Our aim was to provide CMR for assessing LV following acute MI. Firstly, 40 reperfused ST-segment elevation myocardial (STEMI) patients with paired (4 ± 2 days) and follow-up (5 months) scans were analyzed independent reviewers the minimal detectable changes (MDCs) percentage change in end-diastolic volume (%ΔLVEDV),...
Background: In prehypertrophic Fabry disease, low myocardial T1 values, reflecting sphingolipid storage, are associated with early structural and ECG changes. The correlations between values functional parameters have not been explored. Furthermore, the potential prognostic role of in predicting disease worsening is still unknown. Methods: ECG, 2D echocardiography, cardiopulmonary test, cardiac magnetic resonance were performed 44 patients without left ventricular hypertrophy (35.7±14.5...
The aim of this registry was to evaluate the additional prognostic value a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in large cohort consecutive unselected non-ischaemic cardiomyopathy (NICM) patients.In DERIVATE (www.clinicaltrials.gov/registration: RCT#NCT03352648), 1000 (derivation cohort) and 508 (validation NICM patients with chronic heart failure (HF) left ventricular ejection fraction <50% were included. All-cause mortality...
A small but significant reduction in left ventricular (LV) mass after 18 months of migalastat treatment has been reported Fabry disease (FD). This study aimed to assess the effect on FD cardiac involvement, combining LV morphology and tissue characterisation by magnetic resonance (CMR) with cardiopulmonary exercise testing (CPET).Sixteen treatment-naïve patients (4 women, 46.4±16.2 years) involvement (reduced T1 values CMR and/or hypertrophy) underwent ECG, echocardiogram, troponin T...
Background— Cardiac magnetic resonance (CMR) is a robust tool to evaluate left ventricular ejection fraction (LVEF), myocardial salvage index, microvascular obstruction, and hemorrhage in patients with ST-segment–elevation infarction. We evaluated the additional prognostic benefit of CMR score over standard stratification global registry acute coronary events (GRACE) transthoracic echocardiography LVEF measurement. Methods Results— Two hundred nine consecutive infarction (age, 61.4±11.4...
The use of apical views focused on the left atrium (LA) has improved accuracy LA volume evaluation by two-dimensional (2D) echocardiography. However, routine cardiovascular magnetic resonance (CMR) volumes still uses standard 2- and 4-chamber cine images ventricle (LV). To investigate potential LA-focused CMR images, we compared maximuml (LAVmax) minimum (LAVmin) volumes, emptying fraction (LAEF), calculated both long-axis with LAEF obtained short-axis stacks covering LA. strain was also...
Objective To evaluate the prognostic significance of right ventricular function assessed by echocardiography after start or escalation targeted therapy in patients with pulmonary arterial hypertension. Methods Study design: longitudinal study. Setting: tertiary referral centre for Patients: 81 consecutive hypertension (33 naive and 48 prevalent). Interventions: heart catheterisation performed prior to starting escalating repeated 55 4–12 months therapy. Main outcome measure: survival...
ObjectiveClinical studies using serum cardiac biomarkers to investigate a circadian variation in acute myocardial infarct (MI) size ST-segment elevation infarction (STEMI) patients reperfused by primary percutaneous coronary intervention (PPCI) have produced mixed results. We aimed this phenomenon MI measured cardiovascular magnetic resonance (CMR).MethodsPatient-level data was obtained from 4 randomized controlled trials investigating the MI-limiting effects of cardioprotective therapies...
Objectives To investigate sex differences in left ventricular remodelling and outcome patients undergoing surgical or transcatheter aortic valve replacement (SAVR/TAVR). Methods In this multicentre, observational, study with imaging core-lab analysis, severe stenosis (AS) listed for intervention at one of six UK centres were prospectively recruited underwent cardiovascular magnetic resonance imaging. The primary endpoint was all-cause mortality secondary mortality. Results 674 (425 men, 249...
Background Time‐resolved three‐directional velocity‐encoded (4D flow) magnetic resonance imaging (MRI) enables the quantification of left ventricular (LV) intracavitary fluid dynamics and energetics, providing mechanistic insight into LV dysfunctions. Before becoming a support to diagnosis patient stratification, this analysis should prove capable discriminating between clearly different derangements. Purpose To investigate potential 4D flow in identifying dynamic energetics derangements...
Journal Article Cardiac magnetic resonance in the assessment of anomalous right coronary artery originating from left sinus Valsalva Get access Alberto Cipriani, Cipriani Department Cardiac, Thoracic and Vascular Sciences Public Health, University Padua, Via Giustiniani, 2, 35128 ItalyCardiology Unit, Hospital Italy https://orcid.org/0000-0001-7842-6202 Search for other works by this author on: Oxford Academic PubMed Google Scholar Mauro Lo Rito, Rito Congenital Surgery, IRCCS Policlinico...