A5103104660- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Advanced X-ray and CT Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebrovascular and Carotid Artery Diseases
- Atomic and Subatomic Physics Research
- Radiopharmaceutical Chemistry and Applications
- Sarcoidosis and Beryllium Toxicity Research
- Radiation Dose and Imaging
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Orthopedic Surgery and Rehabilitation
- Cardiovascular Function and Risk Factors
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
University College London
2015-2024
University College Hospital
2014-2024
University College London Hospitals NHS Foundation Trust
2012-2023
Royal London Hospital
2014-2021
National Institute for Health Research
2016-2021
Addenbrooke's Hospital
2002-2017
University of Cambridge
2003-2016
Engineering and Physical Sciences Research Council
2016
University of London
2011-2016
Oldham Council
2016
Abstract BACKGROUND. The aim was to assess the relevant distribution of novel PET tracer 68 Ga‐DOTATATE in neuroendocrine tumors (NETs) with combined positron emission tomography / computed (PET/CT) and compare its performance that 18 F‐FDG PET/CT. METHODS. imaging findings on 38 consecutive patients a diagnosis primary or recurrent NET were compared correlated tumor grade histology based ki67 mitotic index. RESULTS. sensitivity PET/CT 82% (31 38) 66% (25 38). 92% (35 There greater uptake...
Inflammation drives atherosclerotic plaque rupture. Although inflammation can be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography ([18F]FDG PET), [18F]FDG lacks cell specificity, and coronary imaging is unreliable because of myocardial spillover. This study tested the efficacy gallium-68-labeled DOTATATE (68Ga-DOTATATE), a somatostatin receptor subtype-2 (SST2)-binding PET tracer, for inflammation. We confirmed 68Ga-DOTATATE binding in macrophages excised...
Our purpose was to compare the performance of <sup>68</sup>Ga-1,4,7,10-tetraazacyclododecane-<i>N,N′,N″,N‴</i>-tetraacetic acid-d-Phe<sup>1</sup>,Tyr<sup>3</sup>-octreotate (DOTATATE), a novel selective somatostatin receptor 2 PET ligand, and <sup>18</sup>F-FDG in detection pulmonary neuroendocrine tumors using PET/CT, with correlation uptake tumor grade on histology. <b>Methods:</b> The imaging findings first 18 consecutive patients (8 men 10 women) (11 typical carcinoids, atypical 1 large...
Abstract Purpose: We prospectively examined the role of tumor textural heterogeneity on positron emission tomography/computed tomography (PET/CT) in predicting survival compared with other clinical and imaging parameters patients non–small cell lung cancer (NSCLC). Experimental Design: The feasibility study consisted 56 assessed consecutive NSCLC (32 males, 24 females; mean age 67 ± 9.7 years) who underwent combined fluorodeoxyglucose (FDG) PET/CT. validation population 66 recruited...
Cardiac death is the leading cause of mortality in patients with sarcoidosis, yet cardiac involvement often remains undetected. Cardiovascular magnetic resonance imaging (CMR) and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) have been used to diagnose sarcoidosis (CS) never simultaneously a cohort. This study sought assess diagnostic prognostic utility simultaneous hybrid PET/MR.Fifty-one consecutive suspected CS (age 50 ± 13 years, 31 males) underwent PET/MR following...
The purpose of this study was to evaluate integrated <sup>18</sup>F-FDG PET/CT in patients with idiopathic pulmonary fibrosis (IPF) and diffuse parenchymal lung disease (DPLD). <b>Methods:</b> Thirty-six consecutive (31 men 5 women; mean age ± SD, 68.7 9.4 y) IPF (<i>n</i> = 18) or other forms DPLD were recruited for high-resolution CT (HRCT), acquired on the same instrument. maximal metabolism measured as a standardized uptake value (SUV<sub>max</sub>). At site, predominant parenchyma HRCT...
Phosphatidylinositol 3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) play a role in the pathogenesis idiopathic pulmonary fibrosis (IPF). Omipalisib (GSK2126458) is potent inhibitor PI3K/mTOR. A randomised, placebo-controlled, double-blind, repeat dose escalation, experimental medicine study omipalisib subjects with IPF was conducted ( NCT01725139 ) to test safety, tolerability, pharmacokinetics pharmacodynamics. dosed at 0.25 mg, 1 mg 2 twice daily for 8 days four cohorts...
The aim of this study was to prospectively compare whole-body PET/MR imaging and PET/CT, qualitatively quantitatively, in oncologic patients assess the confidence degree inter- intraobserver agreement anatomic lesion localization. <b>Methods:</b> Fifty referred for staging with known cancers underwent PET/CT low-dose CT attenuation correction immediately followed by 2-point Dixon correction. scans were obtained according standard protocols (56 ± 20 min after injection an average 367 MBq...
To evaluate multiparametric-MRI (mpMRI) derived histogram textural-analysis parameters for detection of transition zone (TZ) prostatic tumour. Sixty-seven consecutive men with suspected prostate cancer underwent 1.5T mpMRI prior to template-mapping-biopsy (TPM). Twenty-six had 'significant' TZ Two radiologists in consensus matched TPM the single axial slice best depicting tumour, or largest diameter those benign histology, define single-slice whole TZ-regions-of-interest (ROIs)....
The major challenge in pre-surgical epileptic patient evaluation is the correct identification of seizure onset area, especially MR-negative patients. In this study, we aimed to: (1) assess concordance between perfusion, from ASL, and metabolism, (18)F-FDG, acquired simultaneously on PET/MR; (2) verify utility a statistical approach as supportive diagnostic tool for clinical readers. Secondarily, compared (18)F-FDG PET data hybrid PET/MR system with those PET/CT, purpose validate reliability...
This study explores the potential for multifunctional imaging to provide a signature V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog (KRAS) gene mutations in colorectal cancer.This prospective approved by institutional review board comprised 33 patients undergoing PET/CT before surgery proven primary cancer. Tumor tissue was examined histologically presence of KRAS and expression hypoxia-inducible factor-1 (HIF-1) minichromosome maintenance protein 2 (mcm2). The following parameters...
Patients with idiopathic pulmonary fibrosis (IPF) show increased PET signal at sites of morphological abnormality on high-resolution computed tomography (HRCT). The purpose this investigation was to investigate the normal-appearing lung HRCT in IPF.
The study aimed to investigate whether textural features of rectal cancer on MRI can predict long-term survival in patients treated with long-course chemoradiotherapy.Textural analysis (TA) using a filtration-histogram technique T2-weighted pre- and 6-week post-chemoradiotherapy was undertaken TexRAD, proprietary software algorithm. Regions interest enclosing the largest cross-sectional area tumour were manually delineated axial images filtration step extracted at different anatomical scales...
There is a lack of prognostic biomarkers in idiopathic pulmonary fibrosis (IPF) patients. The objective this study to investigate the potential 18F-FDG-PET/ CT predict mortality IPF.A total 113 IPF patients (93 males, 20 females, mean age ± SD: 70 9 years) were prospectively recruited for 18F-FDG-PET/CT. overall maximum uptake 18F-FDG (SUVmax), minimum or background lung activity (SUVmin), and target-to-background (SUVmax/ SUVmin) ratio (TBR) quantified using routine region-of-interest...
The assessment of post-myocardial infarction (MI) left ventricular (LV) remodeling by cardiovascular magnetic resonance (CMR) currently uses criteria defined echocardiography. Our aim was to provide CMR for assessing LV following acute MI. Firstly, 40 reperfused ST-segment elevation myocardial (STEMI) patients with paired (4 ± 2 days) and follow-up (5 months) scans were analyzed independent reviewers the minimal detectable changes (MDCs) percentage change in end-diastolic volume (%ΔLVEDV),...
Background— Hybrid positron emission tomography and magnetic resonance allows the advantages of in tissue characterizing myocardium to be combined with unique metabolic insights tomography. We hypothesized that area reduced myocardial glucose uptake would closely match at risk delineated by T2 mapping ST-segment–elevation infarction patients. Methods Results— using 18 F-fluorodeoxyglucose (FDG) for was performed 21 patients a median 5 days. Follow-up scans were subset 12 months later. The...
The purpose of this study was to investigate the ability computed tomography texture analysis (CTTA) provide additional prognostic information in patients with Hodgkin's lymphoma (HL) and high-grade non-Hodgkin's (NHL). This retrospective, pilot-study approved by IRB comprised 45 undergoing routine 18F-FDG-PET-CT. Progression-free survival (PFS) determined from clinical follow-up (mean-duration: 40 months; range: 10-62 months). Non-contrast-enhanced low-dose CT images were submitted CTTA...
Purpose The primary aim was to compare the diagnostic performance of PET/MRI (performed with basic anatomical MRI sequences) in detecting sites disease adult patients lymphoma compared current standard care, PET/CT. Secondary aims were assess additional value diffusion-weighted imaging detection and evaluate relationship between standardized uptake on PET/MR apparent diffusion coefficient imaging. Methods Sixty-eight studies 66 consecutive histologically proven Hodgkin or non-Hodgkin...