A5066492085- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Teaching and Learning Programming
- Advanced Radiotherapy Techniques
- Lanthanide and Transition Metal Complexes
- Photoacoustic and Ultrasonic Imaging
- Diagnosis and treatment of tuberculosis
- Digital Radiography and Breast Imaging
- Tuberculosis Research and Epidemiology
- Alzheimer's disease research and treatments
- Infectious Diseases and Tuberculosis
- Medical Image Segmentation Techniques
- Dementia and Cognitive Impairment Research
- Atomic and Subatomic Physics Research
- Peripheral Neuropathies and Disorders
- Sarcoidosis and Beryllium Toxicity Research
- SARS-CoV-2 and COVID-19 Research
- Numerical Methods and Algorithms
- Advanced Neuroimaging Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Sexual Differentiation and Disorders
University College London
2012-2023
Royal London Hospital
2021-2023
University College London Hospitals NHS Foundation Trust
2020
A*STAR-NUS Clinical Imaging Research Centre
2016-2019
Stanmore College
2018
University College Hospital
2010-2017
National University of Singapore
2016-2017
Agency for Science, Technology and Research
2016-2017
GTx (United States)
2017
UCL Australia
2011
Positron emission tomography (PET) images are degraded by a phenomenon known as the partial volume effect (PVE). Approaches have been developed to reduce PVEs, typically through utilisation of structural information provided other imaging modalities such MRI or CT. These methods, correction (PVC) techniques, PVEs compensating for effects scanner resolution, thereby improving quantitative accuracy. The PETPVC toolbox described in this paper comprises suite both classic and more recent...
The spatial normalization of PET amyloid imaging data is challenging because different white and gray matter patterns negative (Aβ-) positive (Aβ+) uptake could lead to systematic bias if a standard method used. In this study, we propose the use an adaptive template registration overcome problem.Data from phase II study (n = 72) were used model deposition with investigational agent (18)F-flutemetamol. Linear regression voxel intensities on standardized value ratio (SUVR) in neocortical...
<h3>Abstract</h3> Here we show that deleting NMNAT2 from cortical glutamatergic neurons (NMNAT2 cKO) results in progressive axonal loss, neuroinflammation, small hippocampi and enlarged ventricles. Interestingly, dramatic neuroinflammation responses were observed around the long-range tracts of cKO neurons. In addition to neurodegenerative-like phenotype, also found absence whisker-representation patterns “barrels” primary somatosensory cortex mice. These observations suggest is required...
Patients with idiopathic pulmonary fibrosis (IPF) show increased PET signal at sites of morphological abnormality on high-resolution computed tomography (HRCT). The purpose this investigation was to investigate the normal-appearing lung HRCT in IPF.
Blood-based kinetic analysis of PET data relies on an accurate estimate the arterial plasma input function (PIF). An alternative to invasive measurements from sampling is image-derived (IDIF). However, IDIF provides whole blood radioactivity concentration, rather than required free tracer concentration in plasma. To PIF, we corrected carotid artery with estimates parent fraction (PF) and plasma-to-whole (PWB) ratio obtained five venous samples. We compared combined IDIF+venous approach gold...
Many partial volume correction approaches make use of anatomical information, readily available in PET/MRI systems but it is not clear what approach best. Seven novel to were evaluated, including several post-reconstruction methods and reconstruction that incorporate information. These compared with an MRI-independent (reblurred van Cittert ) uncorrected data. Monte Carlo PET data generated for activity distributions representing both 18F FDG amyloid tracer uptake. Post-reconstruction...
In this paper we propose a segmented magnetic resonance imaging (MRI) prior-based maximum penalized likelihood deconvolution technique for positron emission tomography (PET) images. The model assumes the existence of activity classes that behave like hidden Markov random field (MRF) driven by MRI. We utilize mean approximation to compute MRF. tested our method on both simulated and clinical data (brain PET) compared results with PET images corrected re-blurred Van Cittert (VC) algorithm,...
Abstract Background Interleukin 4 (IL-4), increased in tuberculosis infection, may impair bacterial killing. Blocking IL-4 confers benefit animal models. We evaluated safety and efficacy of pascolizumab (humanized anti–IL-4 monoclonal antibody) as adjunctive treatment. Methods Participants with rifampicin-susceptible pulmonary received a single intravenous infusion or placebo, standard 6-month Pascolizumab dose successive cohorts: (1) nonrandomized 0.05 mg/kg (n = 4); (2) 0.5 (3) randomized...
Abstract INTRODUCTION The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized (CT) data and are influenced by scanner differences, we investigated the transformation with from Insight 46 acquired PET/magnetic resonanceimaging (MRI). METHODS We transformed standardized uptake value ratios (SUVRs) 432 florbetapir PET/MRI scans processed whole cerebellum (WC) white...
MARTIN, EDWARD; THOMAS, BENJAMIN A.; MOORHEAD, STIRLING W.; PILCHER, LEWIS S. Author Information
PET/computed tomography (CT) has been shown to detect lesions in patients with pulmonary tuberculosis (PTB) and may be useful for assessing PTB disease clinical research studies. However, radiation dose is of concern individuals an underlying curable disease. This study aimed determine whether PET/MR equivalent PET/CT PTB.Ten microbiologically confirmed were recruited. Patients received 129.0±4.1 MBq fluorine-18-fluorodeoxyglucose. Five the 10 underwent a scan, followed by PET/CT. The...
Huxley has said, "The man of science learned to believe in justification, not by faith, but verification." With this mind, throughout the past nine months, I have been engaged a study practical utility opsonic index as factor diagnosis, prognosis and therapeusis disease. Lest my attitude on question be misinterpreted, desire primarily state that no reason doubt, and, contrary, entertain implicit faith theory opsonins; practicability medicine, experiments occasioned gravest skepticism, if...
Two years ago in a contribution<sup>1</sup>read before the Philadelphia County Medical Society on subject of opsonins, I made following statements: 1. "In heralded unlimited field therapy, where opsonic index is ordained to play star rôle, its utility seems destined pass into oblivion, not only because inconstancy agreement with clinical symptomatology, but especially impracticability." 2. "Although my experience thus far artificial auto-inoculations has been most gratifying and results...
Abstract In N -methyl-D-aspartate receptor (NMDAR) antibody encephalitis, NMDAR-autoantibodies are hypothesised to cause prominent neuropsychiatric symptoms by internalizing NMDARs. However, supporting evidence comes chiefly from in vitro and rodent data with scant direct affected humans. Here, we used vivo positron emission tomography (PET) [ 18 F]GE-179 show a mean 30% reduction of the density open, activated NMDARs grey matter persistently NMDAR-autoantibody seropositive patients...
The understanding of early events following TB exposure is limited by traditional tests that rely on detection an immune response to infection, which delayed, or imaging with low sensitivity for disease. We investigated evidence lung abnormalities in heavily exposed contacts using PET/MRI.30 household 20 index patients underwent clinical assessment, IGRA testing, chest x-ray and PET/MRI scan 18-F-FDG. MRI images were examined a radiology/nuclear medicine dual-qualified physician standardised...
Single photon emission tomography (SPECT) is widely used in clinical practice for a large number of diagnostic applications. However, different hospitals might use scanners containing hardware and software technologies, therefore making reproducibility results hard task. The aim this work to establish the basis tool able include scanner models facilitate inter-comparison activity measurements across institutions. We open source tomographic image reconstruction (STIR) implemented...
The combination of positron emission tomography (PET) with magnetic resonance (MR) imaging opens the way to more accurate diagnosis and improved patient management. At present, data acquired by PET MR scanners are essentially processed separately, search for ways improve accuracy tomographic reconstruction via synergy two techniques is an active area research. aim collaborative computational project on (CCP-PETMR), supported UK engineering physical sciences research council (EPSRC),...