A5102999909- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Statistical Methods in Clinical Trials
- Respiratory and Cough-Related Research
- Statistical Methods and Bayesian Inference
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Carbon dioxide utilization in catalysis
- Pharmaceutical studies and practices
- Respiratory viral infections research
- biodegradable polymer synthesis and properties
- Electronic Packaging and Soldering Technologies
- 3D IC and TSV technologies
- Cytokine Signaling Pathways and Interactions
- CRISPR and Genetic Engineering
- Blood transfusion and management
- Erythropoietin and Anemia Treatment
- Delphi Technique in Research
- Circular RNAs in diseases
- Organometallic Complex Synthesis and Catalysis
- Air Quality Monitoring and Forecasting
- Pharmacogenetics and Drug Metabolism
Southwest Petroleum University
2025
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2025
Inner Mongolia Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Zhejiang University
2018-2024
University of Pennsylvania
2024
Yangzhou University
2024
Center for Innovation
2024
System Simulation (United Kingdom)
2018-2023
First Affiliated Hospital Zhejiang University
2018-2022
Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal of all fibrotic conditions with no curative therapies. Common pathomechanisms between IPF cancer are increasingly recognised, including dysfunctional pan-PI3 kinase (PI3K) signalling as a driver aberrant proliferative responses. GSK2126458 novel, potent, PI3K/mammalian target rapamycin (mTOR) inhibitor which has recently completed phase I trials in oncology setting. Our aim was to establish scientific dosing...
Abstract The effects of different grades carbon nanotubes on the curing a typical epoxy resin (EPIKOTE™ 862 and EPIKURE™ agent W) were examined via differential scanning calorimetry. It was found that could initiate cure at lower temperatures, while overall process slowed as evidenced by total heat reaction glass transition temperatures cured nanocomposites compared to neat epoxy. This finding is practically important it essential have consistent degree when properties thermosets with...
Phosphatidylinositol 3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) play a role in the pathogenesis idiopathic pulmonary fibrosis (IPF). Omipalisib (GSK2126458) is potent inhibitor PI3K/mTOR. A randomised, placebo-controlled, double-blind, repeat dose escalation, experimental medicine study omipalisib subjects with IPF was conducted ( NCT01725139 ) to test safety, tolerability, pharmacokinetics pharmacodynamics. dosed at 0.25 mg, 1 mg 2 twice daily for 8 days four cohorts...
Cancer expression of PD-L1 suppresses anti-tumor immunity. has emerged as a remarkable therapeutic target. However, the regulation degradation is not understood. Here, we identify several compounds inducers using high-throughput drug screen. We find EGFR inhibitors promote ubiquitination and proteasomal following GSK3α-mediated phosphorylation Ser279/Ser283. ARIH1 E3 ubiquitin ligase responsible for targeting to degradation. Overexpression tumor growth promotes cytotoxic T cell activation in...
Daprodustat, a novel oral hypoxia‐inducible factor prolyl hydroxylase inhibitor is approved in the United States for treatment of anemia due to chronic kidney disease (CKD) adults receiving dialysis at least 4 months. Pharmacodynamic dose‐hemoglobin (Dose‐Hgb) models were developed as daprodustat progressed through development. To support global phase III development, dose‐titration algorithm, guided by simulations from initial Dose‐Hgb model based on II clinical data, was implemented. This...
The propped fracture inflow capacity in unconventional reservoirs' networks is vital for assessing fracturing effects. It's influenced by factors like width (sand spreading concentration), proppant type, and closure pressure. Based on extensive experimental data, a BP neural network prediction model based genetic algorithm was established to realize its efficient accurate prediction. Experiments were conducted using an API-standard flow-conducting chamber test the ability of ceramic quartz...
BackgroundWe evaluated the dose–response of umeclidinium (UMEC; a long-acting muscarinic antagonist) combined with fluticasone furoate (FF; an inhaled corticosteroid [ICS]) in patients asthma.MethodsIn double-blind, three-period crossover study, 421 subjects (symptomatic on ICS), were randomized to sequence three seven treatments: FF 100 mcg alone, UMEC (15.6, 31.25, 62.5, 125, or 250 mcg), vilanterol 25 (a β-agonist), once-daily for 14 days (12–14-day washout). Trough forced expiratory...
BackgroundTo our knowledge, no studies in patients with asthma have assessed a long-acting muscarinic antagonist the absence of inhaled corticosteroids (ICS).ObjectiveEvaluate dose–response, efficacy, and safety umeclidinium (UMEC) not receiving ICS.MethodsIn this double-blind, three-period crossover study, 350 subjects were randomized to sequence three eight treatments: UMEC 15.6, 31.25, 62.5, 125, or 250 mcg once daily (OD), 15.6 31.25 twice (BID), placebo, administered for 14 days...
Clinical Trial Simulations (CTS) are a valuable tool for decision-making during drug development. However, to obtain realistic simulation scenarios, the patients included in CTS must be representative of target population. This is particularly important when covariate effects exist that may affect outcome trial. The objective our investigation was evaluate and compare results using re-sampling from population pool multivariate distributions simulate patient covariates.COPD selected as...
There are no current pharmacological therapies for the prevention or treatment of acute respiratory distress syndrome. Early dysregulated inflammation likely plays a role in syndrome development and possibly outcomes. p38 mitogen-activated protein kinase is central to regulation multiple inflammatory mediators implicated organ dysfunction target novel class cytokine-suppressive anti-inflammatory drugs. In preclinical models, inhibitors reduce lung injury following pancreatitis burn injury.We...
Phosphoinositide 3-kinase <i>δ</i> (PI3K<i>δ</i>) is a lipid kinase involved in leukocyte recruitment and activation. Activation of PI3K<i>δ</i> has been linked to airway inflammation asthma pathogenesis. This randomized, double-blind, placebo-controlled, crossover study investigated the efficacy, safety, tolerability, pharmacokinetics inhibitor, nemiralisib (GSK2269557), patients with persistent, uncontrolled asthma. Patients (<i>n</i> = 50) received once-daily inhaled (1000 <i>µ</i>g) or...
Abstract Ovarian cancer (OC) is the sixth most common in women worldwide. Despite advances detection and therapies, it still represents lethal gynecologic malignancy industrialized countries. Unfortunately, molecular events that lead to development of this highly aggressive disease remain largely unknown. The study explored ability microRNA‐508 (miR‐508) influence proliferation, migration, invasion, epithelial‐mesenchymal transition (EMT) OC cells. We quantified level miR‐508 tissues with...
Intramolecular oxysulfonylation of alkenes with the insertion sulfur dioxide promoted by visible light is developed, leading to sulfonated tetrahydrofurans and related compounds in moderate good yields.
Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF). The TOPICAL study a 4-period, partially-randomised, controlled, crossover four aerosolised approaches IPF subjects. Nine were randomised receive 99mTechnetium-labelled monodisperse (1.5 μm or 6 μm; periods 1 2). Subjects also received radio-labelled using polydisperse nebuliser (period 3) unlabelled (400 μg) pressurized metered dose inhaler volumatic spacer (pMDI;...
This paper uses a simple, fast, and low-cost method to fabricate an arrayed flexible glucose biosensor device. The ruthenium dioxide (RuO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) sensing membranes were deposited on the polyethylene terephthalate substrate by radio frequency sputtering technology. silver paste was fabricated as conducting wire epoxy insulation layer screen-printed technique. oxidase nafion prepared membrane....
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung condition, causing progressive decline in function leading to premature death. Acute exacerbations COPD patients are predominantly associated with respiratory viruses. Ribavirin a generic broad-spectrum antiviral agent that could be used for treatment of viral infections COPD. Using the Particle Replication In Nonwetting Templates (PRINT) technology, which produces dry-powder particles uniform shape and size, two new...
A data set of 90 60-cell module images from 5 commercial PV brands over 6 exposure steps damp-heat testing were analyzed. An automated analysis pipeline was developed using the open source coding language Python to parse into individual cell images. As original raw are not directly suitable for modeling, this algorithm implements techniques which include filtering, thresholding, convex Hull, regression fitting, and perspective transformation pre-process image. After extraction, 5400 as a...
Multilevel models were originally developed to allow linear regression or ANOVA be applied observations that are not mutually independent. This lack of independence commonly arises due clustering the units into ‘higher level units’ such as patients in hospitals. In mixed models, within-cluster correlations modelled by including random effects a model. this paper, we discuss generalizations suitable for responses subject systematic and measurement error interval censoring. The first example...
The multipart Unified Parkinson's Disease Rating Scale is the standard instrument in clinical trials. A sum of scores for all items 1 or more parts usually analysed. Without accounting relative importance individual items, this conceivably does not optimize power instrument. aim was to compare ability detect drug effect slowing down motor function deterioration, as measured by Part III Scale-motor examinations-between item and scores.We used data from 423 patients a disease progression trial...