A5020326835- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Viral Infections and Immunology Research
- Cardiovascular Issues in Pregnancy
- Cardiac Fibrosis and Remodeling
- Adipokines, Inflammation, and Metabolic Diseases
NIHR Leicester Biomedical Research Centre
2017-2025
Glenfield Hospital
2016-2025
University of Leicester
2016-2025
University Hospital Southampton NHS Foundation Trust
2016-2025
Command Hospital
2025
National Institute for Health Research
2016-2024
Brigham and Women's Hospital
2024
Harvard University
2024
King Saud bin Abdulaziz University for Health Sciences
2024
National Heart Lung and Blood Institute
2024
Background: Aortic valve replacement (AVR) for aortic stenosis is timed primarily on the development of symptoms, but late surgery can result in irreversible myocardial dysfunction and additional risk. The aim this study was to determine whether presence focal scar preoperatively associated with long-term mortality. Methods: In a longitudinal observational outcome study, survival analysis performed patients severe listed intervention at 6 UK cardiothoracic centers. Patients underwent...
Myocardial fibrosis is a key mechanism of left ventricular decompensation in aortic stenosis and can be quantified using cardiovascular magnetic resonance (CMR) measures such as extracellular volume fraction (ECV%). Outcomes following valve intervention may linked to the presence extent myocardial fibrosis.This study sought determine associations between ECV% markers post-intervention clinical outcomes.Patients with severe underwent CMR, including quantification modified Look-Locker...
Importance Myocardial fibrosis in aortic stenosis (AS) may exhibit sex differences. However, its prognostic significance women with AS remains unclear. Objective To investigate differences myocardial assessed by cardiovascular magnetic resonance (CMR) and evaluate value men AS. Design, Setting, Participants Patients severe who underwent CMR before valve replacement (AVR) were prospectively enrolled from 13 international sites between March 2011 September 2021. was evaluated using...
To assess cardiovascular magnetic resonance (CMR) measured myocardial perfusion reserve (MPR) and exercise testing in asymptomatic patients with moderate-severe AS. Multi-centre, prospective, observational study, blinded analysis of CMR data. Patients underwent adenosine stress CMR, symptom-limited (ETT) echocardiography were followed up for 12–30 months. The primary outcome was a composite of: typical AS symptoms necessitating referral AVR, death major adverse events. 174 recruited: mean...
Heart failure with preserved ejection fraction (HFpEF) is a poorly characterized condition. We aimed to phenotype patients HFpEF using multiparametric stress cardiovascular magnetic resonance imaging (CMR) and assess the relationship clinical outcomes. One hundred fifty four (51% male, mean age 72 ± 10 years) diagnosis of underwent transthoracic echocardiography CMR during single study visit. The protocol comprised cine, stress/rest perfusion late gadolinium enhancement on 3T scanner....
(i) To establish the test–retest reproducibility of myocardial T1 and extracellular volume (ECV) fraction measurement in asymptomatic patients with moderate–severe aortic stenosis (AS), (ii) to compare using motion-corrected (MOCO) parametric maps for analysis vs. full MOLLI series images, (iii) ECV between age-matched controls. 3 T cardiac MRI was performed twice on 10 (median interval 7 days) assess reproducibility. An additional 40 22 controls underwent a single MRI. Native were...
To assess the cardiac, vascular, anthropometric, and biochemical determinants of subclinical diastolic dysfunction in younger adults with Type 2 diabetes mellitus (T2DM) using multiparametric contrast-enhanced cardiovascular magnetic resonance (CMR) imaging. Twenty <40 years T2DM [mean age 31.8(6.6) years, duration 4.7(4.0) years] 20 sex-matched controls [10 obese non-diabetic 10 lean (LC)] were studied. Cardiac volumes function, circumferential strain peak early rate (PEDSR), myocardial...
Purpose To determine the interstudy reproducibility of myocardial strain and peak early‐diastolic rate (PEDSR) measurement on cardiovascular magnetic resonance imaging (MRI) assessed with feature tracking (FT) tagging, in patients aortic stenosis (AS). Materials Methods Cardiac MRI was performed twice (1–14 days apart) 18 (8 at 1.5 Tesla [T], 10 3T) moderate–severe AS. Circumferential systolic (PSS) PEDSR were measured all patients. Longitudinal PSS using FT patients, tagging 3T sub‐group....
Aortic valve replacement in asymptomatic severe aortic stenosis is controversial. The Early ASYmptomatic Stenosis (EASY-AS) trial aims to determine whether early improves clinical outcomes, quality of life and cost-effectiveness compared a guideline recommended strategy 'watchful waiting'. In pragmatic international, open parallel group randomized controlled (NCT04204915), 2844 patients with will be 1:1 either (surgical or transcatheter) only if symptoms impaired left ventricular function...
Echocardiographic studies indicate South Asian people have smaller ventricular volumes, lower mass and more concentric remodelling than White European people, but there are no data using cardiac MRI (CMR). We aimed to compare CMR quantified structure function in people.
IgA nephropathy (IgAN) is the commonest global cause of glomerulonephritis. Extent fibrosis, tubular atrophy and glomerulosclerosis predict renal function decline. fibrosis assessed with biopsy which invasive prone to sampling error. We utility non-contrast native T1 mapping kidney in patients IgAN for assessment fibrosis. Renal was undertaken 20 10 healthy subjects. Ten had a second scan assess test-retest reproducibility technique. Native times were compared markers disease severity...
Objectives To investigate sex differences in left ventricular remodelling and outcome patients undergoing surgical or transcatheter aortic valve replacement (SAVR/TAVR). Methods In this multicentre, observational, study with imaging core-lab analysis, severe stenosis (AS) listed for intervention at one of six UK centres were prospectively recruited underwent cardiovascular magnetic resonance imaging. The primary endpoint was all-cause mortality secondary mortality. Results 674 (425 men, 249...
The aim of this study was to determine whether left atrial ejection fraction (LAEF) quantified with cardiovascular magnetic resonance (CMR) different between heart failure preserved (HFpEF) and controls, its relation prognosis. As part our single-centre, prospective, observational study, 188 subjects (HFpEF n = 140, controls 48) underwent phenotyping contrast-enhanced CMR, transthoracic echocardiography, blood sampling six-minute walk testing. LAEF calculated using the biplane method. Atrial...
Introduction The pathophysiology of heart failure with preserved ejection fraction (HFpEF) remains incompletely defined. We aimed to characterize HFpEF compared reduced (HFrEF) and asymptomatic hypertensive or non-hypertensive controls. Materials methods Prospective, observational study 234 subjects (HFpEF n = 140; HFrEF 46, controls 48, age 73±8, males 49%) who underwent echocardiography, cardiovascular magnetic resonance imaging (CMR), plasma biomarker analysis (panel 22) 6-minute walk...