A5100777425- Viral Infections and Immunology Research
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Advanced MRI Techniques and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Muscle Physiology and Disorders
- Cardiovascular Function and Risk Factors
- Sarcoidosis and Beryllium Toxicity Research
- Parathyroid Disorders and Treatments
- Mitochondrial Function and Pathology
- Spine and Intervertebral Disc Pathology
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Neurosurgical Procedures and Complications
- Infective Endocarditis Diagnosis and Management
- Genetic Neurodegenerative Diseases
- Acute Myocardial Infarction Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Eosinophilic Disorders and Syndromes
- Pulmonary Hypertension Research and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
University Hospital Münster
2016-2025
Klinik für Schlafmedizin
2019-2024
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2015-2024
Vall d'Hebron Hospital Universitari
2024
Adnan Menderes University
2015-2023
Istanbul Technical University
2022
Van Yüzüncü Yıl Üniversitesi
2022
Ordu University
2015-2019
University of Münster
2016-2017
Schmalkalden University of Applied Sciences
2017
Background— Endomyocardial biopsy (EMB) represents the gold standard for diagnosing myocarditis and nonischemic cardiomyopathies. This study focuses on risk of complications respective diagnostic performance left ventricular (LV), right (RV), or biventricular EMB in patients with suspected and/or cardiomyopathy unknown origin. Methods Results— In this 2-center study, 755 clinically (n=481) origin including those infiltrative connective tissue disease (n=274) underwent either selective LV-EMB...
To evaluate the incidence of coronary vasospasm as a possible pathophysiological mechanism causing chest pain symptoms in patients with clinically suspected myocarditis.Prospective study teaching hospital.85 who presented at hospital atypical and demonstrated clinical signs suggestive myocarditis.Incidence by intracoronary acetylcholine (ACh) testing.The combined procedure ACh testing endomyocardial biopsy (EMB) was performed after ruling out significant artery disease (CAD). EMBs were...
The purpose of this clinical trial was to investigate whether cardiovascular magnetic resonance imaging (CMR) using ferumoxytol (Feraheme™, FH), an ultrasmall superparamagnetic iron oxide nanoparticle (USPIO), allows more detailed characterization infarct pathology compared with conventional gadolinium-based necrosis/fibrosis in patients acute myocardial infarction. Fourteen who had experienced ST-elevation infarction were included study. Following coronary angiography, a first baseline...
Cardiac involvement is a frequent finding in patients with Duchenne (DMD) and Becker (BMD) muscular dystrophies. With this study, we aimed at elucidating the relationship between phenotypic expression of cardiac occurrence adverse events DMD/BMD patients.
Background Patients with mitral valve prolapse (MVP) may develop adverse outcomes even in the absence of regurgitation or left ventricular (LV) dysfunction. Purpose To investigate prognostic value annulus disjunction (MAD) and myocardial fibrosis at late gadolinium enhancement (LGE) cardiac MRI patients MVP without moderate-to-severe LV Materials Methods In this longitudinal retrospective study, 118 144 studies were evaluated between October 2007 June 2020 15 European tertiary medical...
Becker-Kiener muscular dystrophy (BMD) represents an X-linked genetic disease associated with myocardial involvement potentially resulting in dilated cardiomyopathy (DCM). Early diagnosis of cardiac may permit earlier institution heart failure treatment and extend life span these patients. Both echocardiography nuclear imaging methods are capable detecting later stages characterised by wall motion abnormalities. Cardiovascular magnetic resonance (CMR) has the potential to detect depicting...
Duchenne (DMD) and Becker (BMD) muscular dystrophies are X-linked recessive disorders associated with both skeletal myopathy progressive cardiomyopathy in males. Female DMD/BMD carriers (DMDc/BMDc) mostly free of muscle symptoms, but they also prone to cardiomyopathy. The aim the current study was characterize frequency, pattern, extent female comparison their first-degree male MD relatives. Thirty-six (age 44 ± 14 years) (20 DMDc 16 BMDc) constituted 'MD carrier group' were prospectively...
Mitochondrial myopathies (MM) are a heterogeneous group of inherited conditions resulting from primary defect in the mitochondrial respiratory chain with consecutively impaired cellular energy metabolism. Small sized studies using mainly electrocardiography (ECG) and echocardiography have revealed cardiac abnormalities ranging conduction arrhythmias to hypertrophic or dilated cardiomyopathy these patients. Recently, characteristic patterns involvement were documented by cardiovascular...
Background Diagnosis of viral myocarditis is difficult by clinical criteria but facilitated detection inflammation and genomes in endomyocardial biopsies. Parvovirus B19 (B19V) targets endothelial cells where nucleic acid exclusively detected the heart. Microparticles (MPs) are released after cell damage or activation specific cells. We aimed to investigate whether circulating MPs (EMPs) human experimental models associated with B19V myocarditis. Methods were investigated patients (n = 54),...
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and primarily characterised a disease. However, SARS-CoV-2 can directly infect vascular endothelium subsequently cause inflammation, atherosclerotic plaque instability thereby result in both endothelial dysfunction myocardial inflammation/infarction. Interestingly, up to 50% of patients suffer from persistent exercise dyspnoea post-viral fatigue (PVFS) after having overcome an...
Organ fibrosis is a shared endpoint of many diseases, yet underlying mechanisms are not well understood. Several pathways governed by the primary cilium, sensory antenna present on most vertebrate cells, have been linked with fibrosis. Ciliopathies usually start early in life and represent considerable disease burden. We performed massively parallel sequencing using cohorts genetically unsolved individuals unexplained liver kidney failure correlated this clinical, imaging, histopathological...
Abstract Background Cardiac amyloidosis (CA) is an infiltrative disease characterised by accumulation of amyloid deposits in the extracellular space myocardium—comprising transthyretin (ATTR) and light chain (AL) as most frequent subtypes. Histopathological proof endomyocardial biopsy (EMB) gold standard for diagnosis CA. Cardiovascular magnetic resonance (CMR) allows non-invasive workup suspected We conducted a multi-centre study to assess diagnostic value CMR comparison EMB Methods studied...
The purpose of this study was to carefully analyse the therapeutic benefit tafamidis in patients with wild-type transthyretin amyloidosis (ATTRwt) and cardiomyopathy (ATTRwt-CM) after one year therapy based on serial multi-parametric cardiovascular magnetic resonance (CMR) imaging.Non-sponsored data CMR regarding effect cardiac phenotype ATTRwt-CM are not available so far.The present comprised N = 40 who underwent two studies within a follow-up period 12 ± 3 months. Baseline (BL) clinical...
Accurate diagnosis of transthyretin amyloidosis cardiomyopathy (ATTR-CM) and its differentiation from light-chain (AL) cardiac (CA) cases (AL-CM) is paramount importance, since treatment strategies are totally different obviously more successful in case early disease detection. Surprisingly, comparative imaging data based on concurrent cardiovascular magnetic resonance (CMR) bone scintigraphy the same patients with biopsy-proven CA still rare. This was a real-world retrospective...