A5075004971- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Cardiac pacing and defibrillation studies
- Ultrasound and Hyperthermia Applications
- Cerebrovascular and Carotid Artery Diseases
- Cell Adhesion Molecules Research
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac tumors and thrombi
- Cardiovascular Syncope and Autonomic Disorders
- Anodic Oxide Films and Nanostructures
- Advanced Biosensing Techniques and Applications
- GDF15 and Related Biomarkers
- ECG Monitoring and Analysis
- Patient-Provider Communication in Healthcare
- Acute Ischemic Stroke Management
John Radcliffe Hospital
2015-2024
University of Oxford
2015-2024
Oxford University Hospitals NHS Trust
2016-2024
Oxford BioMedica (United Kingdom)
2016-2024
Oxford Health NHS Foundation Trust
2023
Resonance Research (United States)
2016-2022
Wellcome Centre for Integrative Neuroimaging
2015-2021
Brigham and Women's Hospital
2017-2020
Siemens Healthcare (Germany)
2020
Milton Keynes Hospital
2014
Patients with type 2 diabetes mellitus (T2DM) are known to have impaired resting myocardial energetics and perfusion reserve, even in the absence of obstructive epicardial coronary artery disease (CAD). Whether or not pre-existing energetic deficit is exacerbated by exercise, whether causes deoxygenation further derangement during exercise stress, uncertain.
The aim of this study was to evaluate the potential T1 mapping at rest and during adenosine stress as a novel method for ischemia detection without use gadolinium contrast.In chronic coronary artery disease (CAD), accurate is important because targeted revascularization improves clinical outcomes. Myocardial blood volume (MBV) may be more comprehensive marker than myocardial flow. using cardiac magnetic resonance (CMR) highly sensitive changes in water content, including MBV. We propose that...
In patients with angina and nonobstructive coronary artery disease (NOCAD), confirming symptoms due to microvascular dysfunction (CMD) remains challenging. Cardiac magnetic resonance (CMR) assesses myocardial perfusion high spatial resolution is widely used for diagnosing obstructive (CAD).The goal of this study was validate CMR in NOCAD, compared CAD correlated the index microcirculatory resistance (IMR) during invasive angiography.Fifty (65 ± 9 years age) 20 age-matched healthy control...
Atrial fibrillation (AF) is a growing public health burden, and its treatment remains challenge. AF leads to electrical remodeling of the atria, which in turn promotes maintenance resistance treatment. Although has long been therapeutic target AF, causes remain poorly understood. We show that atrial-specific up-regulation microRNA-31 (miR-31) goat human depletes neuronal nitric oxide synthase (nNOS) by accelerating mRNA decay alters nNOS subcellular localization repressing dystrophin...
Background— CMR T1 mapping is a quantitative imaging technique allowing the assessment of myocardial injury early after ST-segment–elevation infarction. We sought to investigate ability acute native differentiate reversible and irreversible its predictive value for left ventricular remodeling. Methods Results— Sixty infarction patients underwent 6-month 3T CMR, including cine, T2-weighted (T2W) imaging, shortened modified look-locker inversion recovery mapping, rest first pass perfusion,...
Lone atrial fibrillation (AF) may reflect a subclinical cardiomyopathy that persists after sinus rhythm (SR) restoration, providing substrate for AF recurrence. To test this hypothesis, we investigated the effect of restoring SR by catheter ablation on left ventricular (LV) function and energetics in patients with but no significant comorbidities.Fifty-three symptomatic paroxysmal or persistent without valvular disease, uncontrolled hypertension, coronary artery thyroid systemic inflammatory...
Novel cardiac magnetic resonance (CMR) stress T1 mapping can detect ischemia and myocardial blood volume changes without contrast agents may be a more comprehensive biomarker than flow.This study describes the performance of first prospective validation against invasive coronary measurements for detecting obstructive epicardial artery disease (CAD), defined by fractional flow reserve (FFR <0.8), microvascular dysfunction, FFR ≥0.8 index microcirculatory resistance (IMR ≥25 U), compared with...
Type 2 diabetes mellitus (T2DM) is associated with coronary microvascular dysfunction in the absence of obstructive artery disease (CAD). Cardiovascular magnetic resonance (CMR) T1-mapping at rest and during adenosine stress can assess vascular reactivity. We hypothesised that non-contrast T1 response to vasodilator will be altered patients T2DM without CAD compared controls due dysfunction. Thirty-one sixteen matched healthy underwent CMR (3 T) for cine, (ShMOLLI), first-pass perfusion late...
Background: T1-mapping using the Shortened Modified Look-Locker Inversion Recovery (ShMOLLI) technique enables non-invasive assessment of important myocardial tissue characteristics.However, tachyarrhythmia may cause mistriggering and inaccurate T1 estimation.We set out to test whether systolic might overcome this, values or data quality would be significantly different compared conventional diastolic T1-mapping.Methods: Native maps were acquired ShMOLLI at 1.5 T (Magnetom Avanto, Siemens...
Perfusion cardiovascular magnetic resonance (CMR) performed with inadequate adenosine stress leads to false-negative results and suboptimal clinical management. The recently proposed marker of adequate stress, the "splenic switch-off" sign, detects splenic blood flow attenuation during perfusion (spleen appears dark), but can only be assessed after gadolinium first-pass, when it is too late optimize response. Reduction in volume expected shorten native T1, which may predict switch-off...
Abstract Aims Patients with persistent atrial fibrillation (AF) experience 50% recurrence despite pulmonary vein isolation (PVI), and no consensus is established for secondary treatments. The aim of our i-STRATIFICATION study to provide evidence stratifying patients AF after PVI optimal pharmacological ablation therapies, through in silico trials. Methods results A cohort 800 virtual patients, variability anatomy, electrophysiology, tissue structure (low-voltage areas, LVAs), was developed...
Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) allows sophisticated quantification of left atrial (LA) blood flow, and could yield novel biomarkers propensity for intra-cardiac thrombus formation embolic stroke. As reproducibility is critically important to diagnostic performance, we systematically investigated technical temporal variation LA 4D in fibrillation (AF) sinus rhythm (SR).
Optical coherence tomography (OCT) is a high resolution imaging technique used to assess superficial atherosclerotic plaque morphology. Utility of OCT may be enhanced by contrast agents targeting molecular mediators inflammation.
Background Atrial fibrillation ( AF ) is associated with myocardial infarction, and patients no obstructive coronary artery disease can present symptoms evidence of cardiac ischemia. We hypothesized that microvascular dysfunction underlies these observations. Methods Results Myocardial blood flow MBF at baseline during adenosine stress left ventricular atrial function were evaluated by magnetic resonance in 49 (25 paroxysmal, 24 persistent) history epicardial or diabetes mellitus, before 6...
Altered left atrial (LA) blood flow characteristics account for an increase in cardioembolic stroke risk fibrillation (AF). Here, we aimed to assess whether exposure factors is sufficient alter LA even the presence of sinus rhythm (SR).
The best pharmacological treatment for each atrial fibrillation (AF) patient is unclear. We aim to exploit AF simulations in 800 virtual atria identify key characteristics that guide the optimal selection of anti-arrhythmic drugs. cohort considered variability electrophysiology and low voltage areas (LVA) was developed validated against experimental clinical data from ionic currents ECG. sustained 494 (62%) atria, with large inward rectifier K
Objective: Atrial fibrillation (AF) is the most common cardiac arrhythmia, with an estimated prevalence of around 1.6% in adult population. The analysis electrocardiogram (ECG) data acquired UK Biobank represents opportunity to screen for AF a large sub-population UK.
Up to 25% of embolic strokes occur in individuals without atrial fibrillation (AF) or other identifiable mechanisms. To assess whether left (LA) blood flow characteristics are associated with brain infarcts, independently AF. The authors recruited 134 patients: 44 a history ischemic stroke and 90 no but CHA2DS2VASc (congestive heart failure, hypertension, age ≥75 [doubled], diabetes, vascular disease, 65 74, sex category [female]) score ≥1. Cardiac magnetic resonance (CMR) evaluated cardiac...
Primary foci of necrobacillosis infection outside the head and neck are uncommon but have been reported in urogenital or gastrointestinal tracts. Reports with Solobacterium moorei rare.A 37-year-old male intravenous drug user was admitted pain his right groin, fever, rigors vomiting following a recent injection into femoral vein. Admission blood cultures grew Fusobacterium nucleatum, Bacteroides ureolyticus. The patient successfully treated penicillin metronidazole.This case report describes...
Abstract Background Atrial fibrillation (AF) has a higher prevalence in men than women and is associated with measures of adiposity lean mass (LM). However, it remains uncertain whether the risks AF these vary by sex. Methods Among 477 904 UK Biobank participants aged 40–69 without prior AF, 23 134 incident cases were identified (14 400 men, 8734 women; median follow-up 11.1 years). Cox proportional hazards models used to estimate covariate adjusted hazard ratios (HRs) describing association...
The rate of left ventricular (LV) lead displacement after cardiac resynchronization therapy (CRT) remains high despite improvements in technology. In 2017, a novel quadripolar with active fixation technology became available the UK.