A5025079912- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Cardiomyopathy and Myosin Studies
- Nitric Oxide and Endothelin Effects
- Cardiovascular and Diving-Related Complications
- Ion channel regulation and function
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Central Venous Catheters and Hemodialysis
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- RNA and protein synthesis mechanisms
- Cardiac Ischemia and Reperfusion
- Antimicrobial Resistance in Staphylococcus
- Mitochondrial Function and Pathology
- Fuel Cells and Related Materials
- Viral Infections and Immunology Research
- ECG Monitoring and Analysis
John Radcliffe Hospital
2008-2025
Oxford University Hospitals NHS Trust
2015-2024
University of Oxford
2007-2024
Milton Keynes Hospital
2019-2024
National Health Service
2023
University of Birmingham
2008-2016
Queen Elizabeth Hospital
2016
Papworth Hospital NHS Foundation Trust
2016
Wiltshire and Swindon History Centre
2013-2016
Queen Elizabeth Hospital Birmingham
2015
Paravalvular leak (PVL) occurs in 5% to 17% of patients following surgical valve replacement. Percutaneous device closure represents an alternative repeat surgery.All UK and Ireland centers undertaking percutaneous PVL submitted data the Registry. Data were analyzed for association with death major adverse cardiovascular events (MACE) at follow-up.Three hundred eight procedures attempted 259 20 (2004-2015). Patient age was 67±13 years; 28% female. The main indications heart failure (80%)...
This work investigates the role of myoglobin in mediating vascular relaxation induced by nitrite. Nitrite, previously considered an inert by-product nitric oxide metabolism, is now believed to play important several areas pharmacology and physiology. Myoglobin can act as a nitrite reductase heart, where it plentiful, but present at far lower level smooth muscle—indeed, its existence vessel wall controversial. Haem proteins have been postulated be nitrite-induced vasodilation, specific...
Nitrite exhibits hypoxia-dependent vasodilator properties, selectively dilating capacitance vessels in healthy subjects. Unlike organic nitrates, it seems not to be subject the development of tolerance. Currently, therapeutic options for decompensated heart failure (HF) are limited. We hypothesized that by preferentially systemic and pulmonary resistance although only marginally vessels, sodium nitrite (NaNO2) infusion would increase cardiac output but reduce arterial blood pressure...
A novel familial arrhythmia syndrome, cardiac ryanodine receptor (RyR2) calcium release deficiency syndrome (CRDS), has recently been described. We evaluated a large and well characterized family to assess provocation testing, risk factor stratification response therapy in CRDS.We present with multiple unheralded sudden deaths aborted arrests, primarily children young adults, no clear phenotype on standard clinical testing.Genetic analysis, including whole genome sequencing, firmly...
The trials upon which recommendations for the use of cardiac resynchronization therapy (CRT) in heart failure used optimal medical (OMT) before sodium-glucose co-transporter 2 inhibitors (SGLT2i). Moreover, SGLT2i included only a small proportion participants with CRT, and therefore, it remains uncertain whether should be considered part OMT prior to CRT.
The objective of this study was to evaluate the cost-effectiveness quadripolar versus bipolar cardiac resynchronization defibrillator therapy systems.Quadripolar left ventricular (LV) leads for reduce phrenic nerve stimulation (PNS) and are associated with reduced mortality compared leads.A total 606 patients received implants at 3 UK centers (319 Q, 287 B), between 2009 2014; mean follow-up 879 days. Rehospitalization episodes were costed National Health Service national tariff rates, EQ-5D...
Abstract Objective: To review the procedures, results and follow‐up of patients who underwent percutaneous device closure a patent foramen ovale (PFO) during pregnancy. We report modifications made to established technique that allowed absolute minimization radiation exposure. Relevant management issues this unusual presentation cardiac disease in pregnancy are discussed. Background: Stroke or immediately prior is catastrophic event. Paradoxical embolism may be more frequent due...
The rate of left ventricular (LV) lead displacement after cardiac resynchronization therapy (CRT) remains high despite improvements in technology. In 2017, a novel quadripolar with active fixation technology became available the UK.
Introduction: Patients with hypertrophic cardiomyopathy (HCM) are at risk for lethal ventricular arrhythmia, but the electrophysiological substrate behind this is not well-understood. We used non-invasive electrocardiographic imaging to characterize patients HCM, including cardiac arrest survivors. Methods: HCM surviving fibrillation or hemodynamically unstable tachycardia (n = 17) were compared without a personal history of potentially arrhythmia 20) and pooled control group structurally...
A grossly obese woman was wrongly diagnosed throughout her adult life of having lymphoedema. Her condition subsequently confirmed as lipoedema, an entirely different condition, which is noted in medical text books but seldom taught to students or general practitioners. The caused by abnormal deposition adipose tissue the extremities (usually lower limbs) and almost exclusively affects women. It often starts at puberty may occur after pregnancy. exact aetiology not yet understood genetic...
Pre-conditioning is an exciting physiological phenomenon that, despite great efforts, has so far resisted translation to mainstream clinical medicine. Many potential triggers (e.g., ischemia of the organ in question or a remote organ, many different drugs) have been investigated, but recent work implicated activation mitochondrial aldehyde dehydrogenase (ALDH2) as central process. A genetic polymorphism, known ALDH2*2, common worldwide (present up 40% Han Chinese people) and produces...
An open letter to the BMA and Academy of Medical Royal Colleges calls on them make a joint public statement opposition amended section 75 regulations
Sixteen years after a long admission for serious occupational accident, 38-year-old man presented with intermittent atypical chest pain. Upon investigations retained fragment of pulmonary artery catheter was found in the right ventricle. Throughout between his accident and current presentation he did not have any symptoms or signs complications associated such as arrhythmia, sepsis thromboembolism. presenting case at medical/surgical multidisciplinary meeting it decided that probability...
A 71-year-old man was transferred to the extraction centre with Staphylococcus aureus endocarditis and a 3.5 × 1.7 cm vegetation adherent ventricular lead of his 7-year-old secondary-prevention dual chamber ICD (see Panel Supplementary material online, Videos S1–S3). He had been initially managed medically but …
The patient is a 67-year-old man who was referred to the rapid access cardiology clinic complaining of episodes chest pain.These were atypical in nature, not reliably related exercise, and occasionally occurring at rest.He had background hypertension hypercholesterolaemia.There no family history coronary artery disease he non-smoker.Exercise tolerance testing performed inconclusive it felt necessary exclude significant with CT angiography.This showed soft plaque right calcification which...