A5103193728- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Xenotransplantation and immune response
- Cardiac and Coronary Surgery Techniques
- Tissue Engineering and Regenerative Medicine
- Animal Genetics and Reproduction
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Mechanical Circulatory Support Devices
- Trauma and Emergency Care Studies
- Cardiovascular and Diving-Related Complications
- Organ Transplantation Techniques and Outcomes
- Virus-based gene therapy research
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Transplantation: Methods and Outcomes
- Atrial Fibrillation Management and Outcomes
- Mechanical Behavior of Composites
- Congenital Heart Disease Studies
- Cardiac Ischemia and Reperfusion
- Obstructive Sleep Apnea Research
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
Papworth Hospital NHS Foundation Trust
2006-2022
Royal Sussex County Hospital
2016-2021
Exponent (United States)
2021
Papworth Hospital
2006-2017
St Thomas' Hospital
2014-2016
Queen Elizabeth Hospital
2016
King's College London
2016
Antwerp University Hospital
2016
University of Birmingham
2016
Guy's and St Thomas' NHS Foundation Trust
2013
Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical replacement and the treatment of choice for patients at high operative risk. The role TAVI in lower risk unclear.To determine whether noninferior surgery moderately increased risk.In this randomized clinical trial conducted 34 UK centers, 913 aged 70 years or older with severe, symptomatic stenosis due age comorbidity were enrolled between April 2014 2018 followed up through 2019.TAVI using any CE mark...
Background— Postprocedural myocardial infarction (type 4a) has been shown to be an adverse prognostic indicator after elective percutaneous coronary intervention (PCI). The Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Stent) study demonstrated that remote ischemic preconditioning reduced procedural symptoms, ECG ST-segment deviation, and cardiac troponin I release PCI the major cerebral event (MACCE) rate at 6 months. We were interested confirm if this early benefit...
Paravalvular leak (PVL) occurs in 5% to 17% of patients following surgical valve replacement. Percutaneous device closure represents an alternative repeat surgery.All UK and Ireland centers undertaking percutaneous PVL submitted data the Registry. Data were analyzed for association with death major adverse cardiovascular events (MACE) at follow-up.Three hundred eight procedures attempted 259 20 (2004-2015). Patient age was 67±13 years; 28% female. The main indications heart failure (80%)...
Abstract: Background: Experience with non‐antigenic galactose α1,3 (αGal) polymers and development of αGal deficient pigs has reduced or eliminated the significance this antigen in xenograft rejection. Despite these advances, delayed rejection (DXR) continues to occur most likely due antibody responses non‐Gal endothelial cell (EC) antigens. Methods: To gauge diversity response we used derived from CD46 transgenic heterotopic cardiac xenografts performed without T‐cell immunosuppression,...
The results of experiments designed to investigate the shock-induced boundary layer on a semi-infinite flat plate are described. Those for laminar shown be in agreement with theory due Lam & Crocco (1958) which describes two distinct domains, one near shock where flow is quasi-steady shock-fixed co-ordinate system and an unsteady region characteristics approach familiar steady state asymptotically. Experimental also presented non-laminar layer. In particular transition turbulence this...
Abstract: Xenotransplantation using porcine organs may resolve a chronic shortage of donor for clinical transplantation if significant immunological barriers can be overcome. To determine the potential role T lymphocytes in Xenograft (Xg) rejection, we transplanted transgenic hCD46 hearts heterotopically into baboon recipients. Methods: Recipients were treated to deplete anti‐Gal antibody with non‐antigenic α‐Gal polyethylene glycol polymer (TPC) (n=2), TPC plus rituximab (anti‐CD20) (n=1)...
Cardiac xenograft function is lost due to delayed rejection (DXR) characterized by microvascular thrombosis and myocardial necrosis. The cause of DXR unknown but may result from induced antibody-mediated activation endothelial cells and/or incompatibilities in thromboregulatory interactions.To examine these issues, a series (Groups 1-6) previous transgenic CD46 pig-to-baboon heterotopic cardiac transplants were reanalyzed for baseline immunosuppressive levels, graft survival infectious...
Transcatheter aortic valve implantation (TAVI) is now the therapy of choice for those patients with severe symptomatic stenosis who are considered to be at too high risk conventional surgery. Balloon valvuloplasty (BAV) routinely performed allow placement balloon-expandable during procedure. Instrumentation has been linked procedural stroke risk, associated runs rapid pacing risking haemodynamic compromise. We outline a novel technique eliminate BAV prior transcatheter placement.We...
We sought to determine whether right ventricular stunning could be detected after supply (during coronary balloon occlusion [BO]) and supply/demand ischemia (induced by rapid pacing [RP] during transcatheter aortic valve replacement) in humans.Ten subjects with single-vessel artery disease undergoing percutaneous intervention normal function were studied the BO group. Ten transfemoral replacement RP In both, a conductance catheter was placed into ventricle, pressure volume loops recorded at...
The aims of the present study were to evaluate how acute systemic hypoxia affects O2 delivery skeletal muscle and consumption (VO2) rat establish these relationships are altered by chronic hypoxia. Thus, effects breathing different concentrations (air, 12% 8% O2) upon oxygen VO2 studied in hindlimb muscles control, normoxic (N) rats that had been made chronically hypoxic a chamber at for 3-4 weeks (CH) rats. Under anaesthesia, arterial blood pressure, femoral flow (FBF), content (Ca,O2)...
To facilitate the application of adenoviral gene therapy in clinical heart transplantation, we developed an ex vivo hypothermic recirculatory transfer method to transplanted pig heart.Experimental animals were assigned into three groups; controls, 1x10(8) plaque-forming units (pfu)/ml group and 1x10(9) pfu/ml group. During 30 min perfusion, 200 ml University Wisconsin solution containing vector was recirculated through coronary vessels. The myocardial temperature maintained below 4 degrees C...
Cobra head configuration of the Amplatzer Septal Occluder (ASO) is a benign but potentially avoidable phenomenon, occurring in approximately 3% implantations. The mechanism deformation thought to occur due device rotation and twisting ASO nytinol wires either delivery catheter or following interaction with adjacent heart structures e.g. left atrial wall after delivery.
The radiological signs of gall-bladder adenomyomatosis are reviewed. Six surgical cases and three further illustrative described. Diagnosis was established on clinical grounds, but microscopic correlation could not be obtained in the majority patients. Microscopic diagnosis is difficult because most specimens opened before being sent for histology. localized area disease therefore easily identified unlikely to sectioned. Radiography offers an image entire functioning wall various states...
Wearable activity monitors, together with smartphone-based health and fitness applications (apps), are becoming more accessible their widespread use provides an additional opportunity for the recording of cardiovascular metrics in patients disease. The selected by cardiac rehabilitation (CR) programmes allows facilitation individualized tailored positive lifestyle changes to places patient at centre recovery programme. To investigate role such devices on outcomes a CR programme,...