A5064534534- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Diabetes Treatment and Management
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Infective Endocarditis Diagnosis and Management
- Heart Failure Treatment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular and Diving-Related Complications
- Anesthesia and Neurotoxicity Research
- High Altitude and Hypoxia
- Mechanical Circulatory Support Devices
- Receptor Mechanisms and Signaling
- Peripheral Artery Disease Management
- Aortic Disease and Treatment Approaches
- Cerebrovascular and Carotid Artery Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Issues in Pregnancy
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
Liverpool Heart and Chest Hospital
2019-2025
University of Liverpool
2019-2025
Liverpool John Moores University
2025
Papworth Hospital
2014-2022
University of Cambridge
2016-2021
Papworth Hospital NHS Foundation Trust
2018-2021
Royal Jubilee Hospital
2019-2020
University of Southampton
2007
Abstract Aims Post-infarction ventricular septal defect (PIVSD) is a mechanical complication of acute myocardial infarction (AMI) with poor prognosis. Surgical repair the mainstay treatment, although percutaneous closure increasingly undertaken. Methods and resuts Patients treated surgical or PIVSD (2010–2021) were identified at 16 UK centres. Case note review was The primary outcome long-term mortality. Patient groups allocated based upon initial management (percutaneous surgical)....
Randomised trials have shown that direct stenting (DS) is associated with improved markers of reperfusion during primary percutaneous coronary intervention (PPCI) for ST elevation myocardial infarction (STEMI). However, data evaluating its impact on long-term clinical outcomes are lacking. We set out to evaluate the effect DS mortality in a contemporary population patients undergoing PPCI STEMI. Consecutive STEMI at two high-volume UK heart attack centres between September 2008– December...
ATP-binding-cassette-transporter-A1 (ABCA1) plays a pivotal role in intracellular cholesterol removal, exerting protective effect against atherosclerosis. ABCA1 gene severe mutations underlie Tangier disease, rare Mendelian disorder that can lead to premature coronary artery disease (CAD), with age of CAD onset being two decades earlier mutant homozygotes and one decade heterozygotes than mutation non-carriers. It is unknown whether common polymorphisms could influence symptom the general...
Background The mechanism underlying the beneficial cardiovascular effects of incretin GLP-1 (glucagon-like peptide 1) and its analogues in humans is elusive. We hypothesized that activating receptors located on vascular smooth muscle cells to induce either peripheral or coronary vasodilatation mediates effect GLP -1. Methods Results Ten stable patients with angina awaiting left anterior descending artery stenting underwent forearm blood flow measurement using plethysmography...
Glucagon-like peptide-1 (7–36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP channels a similar fashion to ischemic conditioning. We investigated whether blockade of with glibenclamide abrogated the protective effect Thirty-two non-diabetic patients awaiting stenting anterior descending artery (LAD) were allocated into 4 groups (control, glibenclamide, GLP-1, +...
Background Adenosine is used to treat no‐reflow in the infarct‐related artery (IRA) during ST‐segment–elevation myocardial infarction intervention. However, physiological effect of adenosine IRA variable. Coronary steal—a reduction blood flow distal coronary bed—can occur response and this facilitated by collaterals. We investigated effects on reserve (CFR) patients presenting with better understand mechanism underpinning variable adenosine. Methods Results Pressure‐wire assessment after...
We sought to determine whether right ventricular stunning could be detected after supply (during coronary balloon occlusion [BO]) and supply/demand ischemia (induced by rapid pacing [RP] during transcatheter aortic valve replacement) in humans.Ten subjects with single-vessel artery disease undergoing percutaneous intervention normal function were studied the BO group. Ten transfemoral replacement RP In both, a conductance catheter was placed into ventricle, pressure volume loops recorded at...
Registry data have suggested higher than anticipated rates of scaffold thrombosis following bioresorbable vascular (BVS) implantation. We examined early neointimal growth and strut coverage in BVS to ascertain whether this was affected by clinical presentation.Patients undergoing optical coherence tomography (OCT)-guided implantation, either for stable angina (SA) or acute coronary syndrome (ACS), were recruited observational study. Repeat OCT performed at follow-up (median 74 days),...
Abstract Background Incretin therapies appear to provide cardioprotection and improve cardiovascular outcomes in patients with diabetes, but the mechanism of this effect remains elusive. We have previously shown that glucagon-like peptide (GLP)-1 is a coronary vasodilator we sought investigate if an adenosine-mediated effect. Methods recruited 41 having percutaneous intervention (PCI) for stable angina allocated them into four groups administering specific study-related infusion following...