A5054731445- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Cardiovascular Function and Risk Factors
- Urinary Tract Infections Management
- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Ultrasound Imaging and Elastography
- Organ Transplantation Techniques and Outcomes
- Ultrasound in Clinical Applications
- Prenatal Screening and Diagnostics
- Ultrasound and Hyperthermia Applications
- Hemodynamic Monitoring and Therapy
- Prostate Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Ectopic Pregnancy Diagnosis and Management
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Urological Disorders and Treatments
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Organ Donation and Transplantation
University College London
2020-2025
University College Hospital
2020-2025
University College London Hospitals NHS Foundation Trust
2020-2023
University College Hospital at Westmoreland Street
2020
Royal London Hospital
2020
National Hospital for Neurology and Neurosurgery
2020
Cambridge University Hospitals NHS Foundation Trust
2010-2019
Papworth Hospital NHS Foundation Trust
2015-2019
Kansas City Public Schools
2019
Addenbrooke's Hospital
2010-2018
Objectives To define terms and processes agree on a minimum dataset in relation to transperineal prostate biopsy procedures enhanced diagnostics. identify the need for further evaluation establish collaborative research practice. Patients Methods A 19‐member multidisciplinary panel rated 66 items their appropriateness definition be incorporated into international databank using R esearch D evelopment/ U niversity of C alifornia L os ngeles ppropriateness M ethod. The item list was developed...
Pressure-volume loops describe dynamic ventricular performance, relevant to patients with and at risk of pulmonary hypertension. We used conductance catheter-derived pressure-volume measure right (RV) mechanics in chronic thromboembolic arterial obstruction different stages pathological adaptation. Resting catheterization was performed 24 patients: 10 hypertension (CTEPH), 7 disease without (CTED), controls. To assess the validity measurements, RV volumes were compared a subset 8...
This study sought to determine whether pre-treatment with intravenous glucagon-like peptide-1 (GLP-1)(7-36) amide could alter myocardial glucose use and protect the heart against ischemic left ventricular (LV) dysfunction during percutaneous coronary intervention. GLP-1 has been shown have favorable cardioprotective effects, but its mechanisms of action remain unclear. Twenty patients preserved LV function single-vessel anterior descending artery disease undergoing elective intervention were...
ABSTRACT Introduction Intravesical Onabotulinum Toxin A (Botox A) injections are an established minimally invasive therapy option for the treatment of refractory overactive bladder (OAB) symptoms in adults. We have assessed whether baseline urodynamic findings can predict self‐reported patient outcomes and posttreatment voiding difficulties. Methods conducted a retrospective review 407 patients (median age 61 years, range 22–94 286 women) who received intravesical Botox non‐neurogenic OAB...
Chronic thromboembolic disease (CTED) is suboptimally defined by a mean pulmonary artery pressure (mPAP) <25 mmHg at rest in patients that remain symptomatic from chronic thrombi. To improve identification of right ventricular (RV) pathology with obstruction, we hypothesized the RV ventriculo-arterial (Ees/Ea) coupling ratio maximal stroke work (Ees/Eamax sw) derived an animal model obstruction may be used to identify occult dysfunction (low Ees/Ea) or residual energetic reserve (high...
Glucagon-like peptide-1 (7–36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP channels a similar fashion to ischemic conditioning. We investigated whether blockade of with glibenclamide abrogated the protective effect Thirty-two non-diabetic patients awaiting stenting anterior descending artery (LAD) were allocated into 4 groups (control, glibenclamide, GLP-1, +...
Summary Target controlled infusion (TCI) devices can be associated with significant safety concerns when used during magnetic resonance imaging (MRI). We tested the and compatibility of newer TCI systems in a 3‐Tesla MRI environment. Two Asena PK two Agilia pumps were to administer propofol (at target blood concentrations 0.5 6.0 μg.ml −1 ) using Marsh model under fields up 50 G T2‐weighted sequence. assessed for projectile risk, accuracy drug delivery, alarm function effects on MR image...
We sought to determine whether right ventricular stunning could be detected after supply (during coronary balloon occlusion [BO]) and supply/demand ischemia (induced by rapid pacing [RP] during transcatheter aortic valve replacement) in humans.Ten subjects with single-vessel artery disease undergoing percutaneous intervention normal function were studied the BO group. Ten transfemoral replacement RP In both, a conductance catheter was placed into ventricle, pressure volume loops recorded at...
To investigate the effect of use different machine-probe combinations on measurement variability and to assess how this impacts accuracy pregnancy dating.Sixteen ultrasound were used for lateral targets spaced 10 40 mm apart axial 50 in an phantom, differences between measured true values determined. The mean 40-mm measurements was estimate gestational age using standard obstetric dating tables crown-rump length (CRL) femur (FL) 50-mm biparietal diameter (BPD).As absolute became larger,...
Right ventricular (RV) dysfunction and heart failure with preserved ejection fraction may contribute to exercise intolerance in obesity. To further define RV responses, we investigated RV–arterial coupling obesity without development of pulmonary venous hypertension (ePVH). defined as end-systolic elastance/pulmonary artery elastance (Ees/Ea) was calculated from invasive cardiopulmonary test data 6 controls, 8 obese patients ePVH (Obese−ePVH) (Obese+ePVH) within a larger series. resting...
Stunning and cumulative ischemic dysfunction occur in the left ventricle with coronary balloon occlusion. Glucagon-like peptide (GLP)-1 protects against this dysfunction. This study used a conductance catheter method to evaluate whether right (RV) developed similar during artery occlusion GLP-1 was protective. In study, RV underwent significant stunning However, did not protect when infused after
Objectives To determine the effect of different ultrasound machine–probe combinations on nuchal translucency (NT) measurements and to assess how this impacts accuracy NT-derived component first-trimester screening for trisomy 21. Methods Sixteen were used axial measurement 2.0-, 3.0- 4.0-mm spaced targets in an phantom. Differences between measured known values determined. The mean was calculate adjusted risks 21, given specific clinical scenarios. Results observed using 2.0-mm target ranged...