A5074155434- Carcinogens and Genotoxicity Assessment
- Cardiovascular Function and Risk Factors
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Pulmonary Hypertension Research and Treatments
- DNA Repair Mechanisms
- Genetically Modified Organisms Research
- Congenital Heart Disease Studies
- Air Quality and Health Impacts
- Acoustic Wave Resonator Technologies
- Environmental Toxicology and Ecotoxicology
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Cardiac Imaging and Diagnostics
- Pharmaceutical and Antibiotic Environmental Impacts
- Molecular Biology Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Animal testing and alternatives
- Occupational Health and Performance
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
Health Canada
2015-2024
University of Ottawa
2013-2024
South Eastern Sydney Local Health District
2024
Cambridge University Hospitals NHS Foundation Trust
2011-2022
Prince of Wales Hospital
2010-2022
Anglia Ruskin University
2012-2022
Centre International de Recherche sur le Cancer
2022
National Research Institute of Brewing
2021
Addenbrooke's Hospital
2008-2018
Harefield Hospital
2018
Background— Ischemic preconditioning reduces local tissue injury caused by subsequent ischemia-reperfusion (IR), but may also have a salutary effect on IR of tissues remote from those undergoing preconditioning. We tested the hypothesis that limb ischemia induces preconditioning, endothelial in humans, and experimental myocardial infarct size. Methods Results— Endothelial human forearm was induced 20 minutes upper (inflation blood pressure cuff to 200 mm Hg) followed reperfusion. Remote...
Background— We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of left ventricular contractile function. In this study, we assessed the utility IVA to measure right (RV) Methods and Results— examined 8 pigs by using tissue Doppler imaging RV free wall simultaneous measurements intraventricular pressure, volume, maximal elastance (e max ), preload recruitable stroke work, dP/dt conductance catheterization. Animals were paced in atrium at...
The chemical composition of tobacco smoke has been extensively examined, and the presence known suspected carcinogens in such contributed to link between smoking adverse health effects. consumption marijuana through remains a reality and, among youth, seems be increasing. There have only limited examinations smoke, including for cannabinoid content tar generation. not extensive studies chemistry especially direct comparison smoke. In this study, systematic both mainstream sidestream from...
Viability, cell cycle effects, genotoxicity, reactive oxygen species production, and mutagenicity of C(60) fullerenes (C(60)) single-walled carbon nanotubes (SWCNT) were assessed in the FE1-Mutatrade markMouse lung epithelial line. None these particles induced death within 24 hr at doses between 0 200 microg/ml or during long-term subculture exposure (576 hr) 100 microg/ml, as determined by two different assays. However, proliferation was slower with SWCNT a larger fraction cells G1 phase....
We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of right ventricular contractile function. In this study, we assessed the usefulness IVA to measure left (LV) function and force-frequency relationships in an experimental preparation.In study 1, examined 6 pigs by use tissue Doppler imaging LV free wall simultaneous measurements intraventricular pressure, volume, maximal elastance (Emax), dP/dtmax conductance catheterization. Animals...
Hundreds of thousands people worldwide live or work in close proximity to steel mills. Integrated production generates chemical pollution containing compounds that can induce genetic damage (1, 2). Previous investigations herring gulls the Great Lakes demonstrated elevated DNA mutation rates near mills (3, 4) but could not determine importance airborne aquatic routes contaminant exposure, eliminate possible confounding factors such as nutritional status and disease burden. To address these...
Abstract This investigation was undertaken to provide quantitative estimates of soil ingestion in young children on a population basis, and identify demographic behavioral characteristics that influence the amount ingested. A total 104 between ages 2 7 yr were selected randomly from three-city area southeastern Washington State. Using aluminum, silicon, titanium as tracer elements, mass-balance approach employed assess daily ingestion. duplicate all food items consumed, feces, some urine...
Settled house dust (SHD) may be a significant source of children's indoor exposure to hazardous substances including polycyclic aromatic hydrocarbons (PAHs). In this study, organic extracts sieved vacuum cleaner from 51 homes were examined for the presence 13 PAHs via GC/MS. found in all samples with levels total ranging between 1.5 and 325 µg g−1. The PAH concentrations SHD correlated information contained corresponding household questionnaires. Analyses showed negatively associated...
Genetic toxicology studies are required for the safety assessment of chemicals. Data from these have historically been interpreted in a qualitative, dichotomous “yes” or “no” manner without analysis dose–response relationships. This article is based upon work an international multi-sector group that examined how quantitative relationships vitro and vivo genetic data might be used to improve human risk assessment. The three approaches analyzing curves deriving point-of-departure (POD) metrics...
Genetic toxicology data have traditionally been employed for qualitative, rather than quantitative evaluations of hazard. As a continuation our earlier report that analyzed ethyl methanesulfonate (EMS) and methyl (MMS) dose-response (Gollapudi et al., 2013), here we present analyses 1-ethyl-1-nitrosourea (ENU) 1-methyl-1-nitrosourea (MNU) additional approaches the determination genetic toxicity point-of-departure (PoD) metrics. We previously described methods to determine...
Background— The incretin hormone glucagon-like peptide-1 (GLP-1) has been shown to have cardioprotective properties in animal models of ischemia and infarction due promotion myocardial glucose uptake suppression apoptosis. We investigated whether GLP-1 protected the heart from dysfunction caused by supply during percutaneous coronary intervention (PCI). Methods Results— Twenty patients with normal left ventricular (LV) function single-vessel disease within anterior descending artery...
The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures scientific review and evaluation of carcinogenic hazards independent experts. Preamble to IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations a 2018 expert advisory group. This article presents key features Preamble, major milestone that will enable take advantage recent procedural advances made during 12 years since last amendments....
This is the second of two reports from International Workshops on Genotoxicity Testing (IWGT) Working Group Quantitative Approaches to Genetic Toxicology Risk Assessment (the QWG). The first report summarized discussions and recommendations QWG related need for quantitative dose-response analysis genetic toxicology data, existence appropriate evaluation threshold responses, methods analyze exposure-response relationships derive points departure (PoDs) which acceptable exposure levels could...
This report summarizes the discussion, conclusions, and points of consensus IWGT Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment (QWG) based a meeting in Foz do Iguaçu, Brazil October 31–November 2, 2013. Topics addressed included (1) need for quantitative dose–response analysis, (2) methods analyze exposure–response relationships & derive point departure (PoD) metrics, (3) mechanistic threshold considerations, (4) approaches define exposure-related risks, (5)...