A5063607309- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Lung Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Multiple and Secondary Primary Cancers
- Lung Cancer Research Studies
- Nutrition, Genetics, and Disease
- Chronic Kidney Disease and Diabetes
- Bladder and Urothelial Cancer Treatments
- Cardiovascular Health and Risk Factors
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Folate and B Vitamins Research
- Health Promotion and Cardiovascular Prevention
- Viral-associated cancers and disorders
- IL-33, ST2, and ILC Pathways
- Advanced Proteomics Techniques and Applications
- Esophageal Cancer Research and Treatment
- Global Public Health Policies and Epidemiology
- Injury Epidemiology and Prevention
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Ergonomics and Musculoskeletal Disorders
Centre International de Recherche sur le Cancer
2021-2024
Abstract Identification of risk biomarkers may enhance early detection smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis 731 smoking-matched case-control sets nested within six prospective cohorts from the US, Europe, Singapore, Australia. identify 36 with independently reproducible associations imminent cancer (all p < 4 × 10 −5 ). These include a few markers (e.g. CA-125/MUC-16 CEACAM5/CEA) that have...
Abstract Differences in the average age at cancer diagnosis are observed across countries. We therefore aimed to assess international variation median of common cancers worldwide, after adjusting for differences population structure. used IARC's Cancer Incidence Five Continents (CI5) Volume XI database, comprising diagnoses between 2008 and 2012 from population‐based registries 65 calculated crude ages lung, colon, breast prostate each country, then adjusted using indirect standardization....
The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program is an NCI-funded initiative with objective to develop tools optimize low-dose CT (LDCT) lung cancer screening. Here, we describe the rationale design for Biomarker Nodule Malignancy projects within INTEGRAL. overarching goal these systematically investigate circulating protein markers include on a panel use (i) pre-LDCT, identify people likely benefit from screening, (ii) post-LDCT, differentiate benign versus...
Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine pathway tryptophan metabolism increase during inflammation, particularly response to interferon-gamma (IFN-γ). Neopterin and kynurenine/tryptophan ratio (KTR) are IFN-γ induced inflammatory markers, together with C-reactive protein (CRP) kynurenines they associated various diseases, but comprehensive data on strength associations markers circulating lacking. We measured neopterin, CRP, seven 5314...
We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with smoking-based (PLCOm2012) commercially available autoantibody biomarker test.
PURPOSE To investigate whether postdiagnosis smoking cessation may affect the risk of death and disease progression in patients with renal cell carcinoma (RCC) who smoked at time diagnosis. METHODS Two hundred twelve primary RCC were recruited between 2007 2016 from Urological Department N.N. Blokhin National Medical Research Center Oncology, Moscow, Russia. Upon enrollment, a structured questionnaire was completed, followed annually through 2020 to repeatedly assess their status...
Abstract Imbalances of blood biomarkers are associated with disease, and may also vary non-pathologically across population groups. We described variation in concentrations one-carbon metabolism, vitamin status, inflammation including tryptophan endothelial renal function among cancer-free older adults. analyzed 5167 controls aged 40–80 years from 20 cohorts the Lung Cancer Cohort Consortium (LC3). Centralized biochemical analyses 40 plasma or serum were performed. fit multivariable linear...
Abstract Background: We evaluated the temporal association between kidney function, assessed by estimated glomerular filtration rate (eGFR), and risk of incident renal cell carcinoma (RCC). also whether eGFR could improve RCC discrimination beyond established factors. Methods: analyzed UK Biobank cohort, including 463,178 participants whom 1,447 were diagnosed with during 5,696,963 person-years follow-up. using flexible parametric survival models, adjusted for C-reactive protein was...
<p>Supplemental Figure 1 shows the flowchart of study.</p>
<p>Supplementary File 1 contains the risk score.</p>
<p>Supplemental figure 3 shows the estimated 1-year and 5-years risk of RCC with eGFRcreat_cystC by common factors across ages for females.</p>
<p>Supplemental figure 4 shows the estimated 5-years risk of RCC with eGFRcreat-cystC by combination common factors across ages, sex.</p>
<div>AbstractBackground:<p>We evaluated the temporal association between kidney function, assessed by estimated glomerular filtration rate (eGFR), and risk of incident renal cell carcinoma (RCC). We also whether eGFR could improve RCC discrimination beyond established factors.</p>Methods:<p>We analyzed UK Biobank cohort, including 463,178 participants whom 1,447 were diagnosed with during 5,696,963 person-years follow-up. using flexible parametric survival models,...
<p>Supplemental figure 2 shows the estimated 5-years risk of RCC with eGFRcreat_cystC by common factors across ages for males.</p>
<p>Supplemental figure 5 shows the comparison of original and updated 1-year 5-years risk RCC for participants with without diagnosis in training testing set UKB.</p>
Abstract Background: In the NCI-funded Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program, Cohort Consortium (LC3) recently identified 36 proteins associated with lung cancer risk in pre-diagnostic blood samples after evaluating 1,161 731 case-control pairs (Nature Communications, 2023). Based on these data, we designed INTEGRAL panel, which measures absolute concentrations 21 proteins, to optimize assessment for screening beyond prediction models (e.g. PLCOm2012) or...