A5072715482- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Fungal and yeast genetics research
- Microtubule and mitosis dynamics
- Genetically Modified Organisms Research
- Effects and risks of endocrine disrupting chemicals
- DNA and Nucleic Acid Chemistry
- Genomic variations and chromosomal abnormalities
- Plant Genetic and Mutation Studies
- Cancer-related Molecular Pathways
- Light effects on plants
- Plant tissue culture and regeneration
- Radiation Effects and Dosimetry
- Environmental Toxicology and Ecotoxicology
- Toxic Organic Pollutants Impact
- COVID-19 and healthcare impacts
- Chromosomal and Genetic Variations
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Photosynthetic Processes and Mechanisms
- Esophageal Cancer Research and Treatment
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Pesticide Exposure and Toxicity
Edinburgh Cancer Research
2023
John Wiley & Sons (United States)
2023
University College London
2019-2022
Charité - Universitätsmedizin Berlin
2022
Royal National Orthopaedic Hospital NHS Trust
2022
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
Abstract A mechanistic understanding of carcinogenic genotoxicity is necessary to determine consequences chemical exposure on human populations and improve health risk assessments. Currently, linear dose-responses are assumed for DNA reactive compounds, ignoring cytoprotective processes that may limit permanent damage. To investigate the biological significance low-dose exposures, lymphoblastoid cells were treated with alkylating agents have different mechanisms action targets: methylmethane...
The demonstration and acceptance of dose response thresholds for genotoxins may have substantial implications the setting safe exposure levels. Here we test hypothesis that direct-acting DNA reactive agents exhibit thresholded responses. We examine potential mechanisms involved in such responses, particularly relation to those alkylating agents. As are representative model compounds with well characterized activities targets, they could help shed light on general responses genotoxins....
Bile acids are often refluxed into the lower oesophagus and candidate carcinogens in development of oesophageal adenocarcinoma. We show here that secondary bile acid, deoxycholic acid (DCA), is only one commonly tested here, to genotoxicity, terms chromosome damage mutation induction human p53 gene. This genotoxicity was apparent at both neutral acidic pH, whilst there a considerable increase bile-induced toxicity pH. The higher levels cell death low survival rates pH may imply exposure...
Warthin's tumour of the salivary glands is composed oncocytic cells containing excessive numbers mitochondria which show frequent structural abnormalities and reduced metabolic function. Recent evidence a strong association between cigarette smoking occurrence prompted this study, to look for damage mitochondrial DNA (mtDNA) that could be result an increase in oxidative stress; two-colour fluorescence situ hybridization (FISH) was developed distribution with deleted mtDNA paraffin...
SUMMARY: The sensitivity of Saccharomyces cerevisiae to sphaeroplast formation has been examined during the transition from exponential phase growth stationary phase. Exponential-phase yeasts are sensitive while resistant. During period, there is a rapid increase in resistance formation. This can be inhibited by treatment with either cycloheximide or 5-fluorouracil. It suggested that characteristic stationary-phase result specific modification period which dependent on both RNA and protein synthesis.