A5045758740- Glioma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- DNA Repair Mechanisms
- Orthodontics and Dentofacial Orthopedics
- Prenatal Substance Exposure Effects
- Neonatal and fetal brain pathology
- Pituitary Gland Disorders and Treatments
- Metabolomics and Mass Spectrometry Studies
- AI in cancer detection
- Gene expression and cancer classification
- Birth, Development, and Health
- Molecular Biology Techniques and Applications
- Carcinogens and Genotoxicity Assessment
- Glycosylation and Glycoproteins Research
- Medical Imaging Techniques and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Brain Metastases and Treatment
- Diet and metabolism studies
- Dental Radiography and Imaging
- Cancer, Hypoxia, and Metabolism
- Genetic Neurodegenerative Diseases
- Cancer Genomics and Diagnostics
- Anesthesia and Neurotoxicity Research
Swansea University
2014-2024
Provision Center for Proton Therapy
2024
Universidad de Londres
2022
University of Alabama at Birmingham
2021
Charing Cross Hospital
1992-2019
Calon Cardio (United Kingdom)
2017-2018
Royal United Hospital
2017
Children's National
2017
Hywel Dda University Health Board
2016
Noah's Ark Children's Hospital for Wales
2016
Abstract All mammalian cells express 3 closely related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogenesis when they are mutationally activated at codon 12, 13, or 61. Although there is a high degree of similarity among the isoforms, K-Ras mutations far more frequently observed in cancer, each isoform displays preferential coupling to particular cancer types. We examined mutational spectra isoforms curated from large-scale tumor profiling found exhibits surprisingly...
Fluid attenuated inversion recovery pulse sequences with a long echo time (TE) have been used to image the brain in one volunteer and four patients. The this sequence suppresses signal from CSF TE produces very heavy T2 weighting. marked reduction flow artefact high weighting enabled anatomical detail be seen within stem produced lesion contrast areas close CSF. Lesions were demonstrated greater conspicuity than conventional T2-weighted patients cerebral infarction, low grade astrocytoma, diplegia.
Survival time for lung cancer is poor with over 90% of patients dying within five years diagnosis primarily due to detection at late stage. The main objective this study was evaluate Fourier transform infrared spectroscopy (FTIR) as a high throughput and cost effective method identifying biochemical changes in sputum biomarkers cancer. Sputum collected from 25 the Medlung observational healthy controls. FTIR spectra were generated cell pellets using wavenumbers 1800 950 cm-1 "fingerprint"...
Inversion recovery (IR) sequences with an inversion time (TI) designed to markedly reduce or null the signal from CSF (TI of ∼2,100 ms at 1.0 T) and a very long echo (TE) 240 were used image brain two normal adult volunteers, one 34-year-old man intrinsic tumor, 3-month-old infant infarct. Using these heavily T2-weighted pulse sequences, gray white matter showed similar intensity in may areas brain, but regions centrum semiovale, posterior internal capsule, parietopontile tract,...
Lung cancer (LC) is the most prevalent worldwide, and responsible for over 1.3 million deaths each year. Currently, LC has a low five year survival rates relative to other cancers, thus, novel methods screen diagnose malignancies are necessary improve patient outcomes. Here, we report on pilot-sized study evaluate potential of sputum microbiome as source non-invasive bacterial biomarkers lung status stage. Spontaneous samples were collected from ten patients referred with possible LC, which...
Acquisition of a mucoid phenotype by Pseudomonas sp. in the lungs cystic fibrosis (CF) patients, with subsequent over-production extracellular polymeric substance (EPS), plays an important role mediating persistence multi-drug resistant (MDR) infections. The ability low molecular weight (Mn = 3200 g mol-1) alginate oligomer (OligoG CF-5/20) to modify biofilm structure aeruginosa (NH57388A) was studied vitro using scanning electron microscopy (SEM), confocal laser (CLSM) Texas Red...
Journal Article THE FATE OF SUBEPENDYMAL CELL IN ADULT RAT BRAIN, WITH A NOTE ON ORIGIN MICROGLIA Get access P. D. LEWIS From the M.R.C. Research Group in Applied Neurobiology, Institute of NeurologyQueen Square, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 91, Issue 4, December 1968, Pages 721–736, https://doi.org/10.1093/brain/91.4.721 Published: 01 1968
Three hundred and eleven patients with classical or definite rheumatoid arthritis were observed over an 11-year period. This group is of particular interest since 214 given cytotoxic therapy, 203 treated azathioprine (52 these also received chlorambucil cyclophosphamide), 11 cyclophosphamide alone. Forty-six died. excess mortality compared the expected rate for general population matched respect to age sex. The death was higher than in 45-64 years but lower those aged 75 over. There more...
The mongolian gerbil has an anomalous circle of Willis, lacking a major posterior communicating artery. Fatal cerebral infarction followed unilateral carotid artery ligation in the neck 60% cases studied. This mortality was reduced by large intraperitoneal injections dexamethasone. Evidence is presented that this reduction associated with significant edema infarcted hemisphere.
Journal Article CARCINOMA OF THE CHOROID PLEXUS Get access PAUL LEWIS From The London HospitalLondon E.1 Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 90, Issue 1, March 1967, Pages 177–186, https://doi.org/10.1093/brain/90.1.177 Published: 01 1967
The host- and bacteria-derived extracellular polysaccharide coating of the lung is a considerable challenge in chronic respiratory disease powerful barrier to effective drug delivery. A low molecular weight 12–15-mer alginate oligosaccharide (OligoG CF-5/20), derived from plant biopolymers, was shown modulate polyanionic components this coating. Molecular modeling Fourier transform infrared spectroscopy demonstrated binding between OligoG CF-5/20 mucins. Ex vivo studies showed induced...
Object The aim of this study was to evaluate the effectiveness brachytherapy using GliaSite Radiation Therapy System in patients with a newly diagnosed resected single brain metastasis. primary end point local tumor control. secondary points included patient survival, distant recurrence, quality life, and treatment toxicity. Methods authors conducted prospective multiinstitutional phase II prescribed at 60-Gy dose administered 1-cm depth after resection No whole-brain radiation therapy...