A5103358062- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Infective Endocarditis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cellular transport and secretion
- Cardiovascular Function and Risk Factors
- Lipid Membrane Structure and Behavior
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Connexins and lens biology
- Cardiovascular and Diving-Related Complications
- Coronary Artery Anomalies
- Cardiovascular Conditions and Treatments
- Cardiac pacing and defibrillation studies
- Cardiovascular Syncope and Autonomic Disorders
- Acute Ischemic Stroke Management
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
Rigshospitalet
2018-2025
Copenhagen University Hospital
2021-2025
University of Copenhagen
2021
Aarhus University Hospital
2011-2020
University College London
2002-2019
Aarhus University
2010-2016
Freie Universität Berlin
2006-2012
SickKids Foundation
2012
Hospital for Sick Children
2002-2012
Great Ormond Street Hospital
2002-2012
Background— Ischemic preconditioning reduces local tissue injury caused by subsequent ischemia-reperfusion (IR), but may also have a salutary effect on IR of tissues remote from those undergoing preconditioning. We tested the hypothesis that limb ischemia induces preconditioning, endothelial in humans, and experimental myocardial infarct size. Methods Results— Endothelial human forearm was induced 20 minutes upper (inflation blood pressure cuff to 200 mm Hg) followed reperfusion. Remote...
Background— We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of left ventricular contractile function. In this study, we assessed the utility IVA to measure right (RV) Methods and Results— examined 8 pigs by using tissue Doppler imaging RV free wall simultaneous measurements intraventricular pressure, volume, maximal elastance (e max ), preload recruitable stroke work, dP/dt conductance catheterization. Animals were paced in atrium at...
Remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction increases salvage. We investigated the effect of remote on long-term clinical outcome. From February 2007 November 2008, 333 a suspected first acute were randomized receive (n = 166) or without 167) (intermittent arm ischaemia through four cycles 5-min inflation followed by deflation blood-pressure cuff). Patient follow-up extended from randomization...
BackgroundRemote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown reduce myocardial infarct size in patients ST-elevation infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote could incidence of cardiac death hospitalisation for heart failure at 12 months.MethodsWe did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) 33...
Abstract This report from the European Society of Cardiology (ESC) Atlas Project updates and expands upon 2021 in presenting cardiovascular disease (CVD) statistics for ESC member countries. paper examines inequalities healthcare outcomes countries utilizing mortality risk factor data World Health Organization Global Burden Disease study with additional economic Bank. Cardiovascular were collected by questionnaire circulated to national cardiac societies Statistics pertaining 2022, or latest...
We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of right ventricular contractile function. In this study, we assessed the usefulness IVA to measure left (LV) function and force-frequency relationships in an experimental preparation.In study 1, examined 6 pigs by use tissue Doppler imaging LV free wall simultaneous measurements intraventricular pressure, volume, maximal elastance (Emax), dP/dtmax conductance catheterization. Animals...
Remote ischemic preconditioning (RIPC) induced by transient limb ischemia releases a dialysable circulating protective factor that reduces ischemia-reperfusion injury. Exercise performance in highly trained athletes is limited tissue hypoxemia and acidosis, which may therefore represent type of stress modifiable RIPC.National-level swimmers, 13-27 yr, were randomized to RIPC (four cycles 5-min arm ischemia/5-min reperfusion) or low-pressure control procedure, with crossover. In study 1,...
<h3>Objective</h3> To assess the association between a patent ductus arteriosus (PDA) on day 3 of life and severe morbidity mortality. <h3>Design</h3> Cohort study. <h3>Setting</h3> Neonatal Intensive Care Unit, Aarhus University Hospital, Denmark. <h3>Patients</h3> All neonates with gestational age less than 32 weeks admitted from 2010 to 2012. <h3>Interventions</h3> (n=183) were routinely screened echocardiography for PDA life. Information baseline characteristics outcome was collected by...
Local and remote ischemic preconditioning (IPC) reduce ischemia-reperfusion (I/R) injury preserve cardiac function. In this study, we tested the hypothesis that is memorized by explanted heart yields protection from subsequent I/R underlying mechanism involves sarcolemmal mitochondrial ATP-sensitive K(+) (K(ATP)) channels. Male Wistar rats (300-350 g) were randomized to a control (n = 10), IPC local group 10). Remote was induced four cycles of 5 min limb ischemia, followed reperfusion. 2...
Background— We have found that remote ischemic conditioning (rIC), adjunctive to primary angioplasty, increases myocardial salvage in patients with ST-segment elevation infarction (STEMI) and extensive area at risk (AAR). The present substudy aimed evaluate the short-term effects of rIC on left ventricular (LV) function. Methods Results— Patients a first STEMI were randomized (4 cycles 5 minutes upper-limb ischemia) during transfer percutaneous coronary intervention (pPCI) (n=123) versus...
Background and Purpose— Remote ischemic preconditioning is a phenomenon by which short period of sublethal ischemia to an organ protects against subsequent in another organ. We have recently demonstrated that remote conditioning transient hind limb delivered during before reperfusion can provide potent cardioprotection, we termed per-conditioning. This study evaluated whether per-conditioning may neuroprotection clinically relevant rat model acute stroke. Methods— was used middle cerebral...
Endosomes and endosomal vesicles (EVs) rapidly move along cytoskeletal filaments allowing them to exchange proteins lipids between different compartments, lysosomes, the trans-Golgi network (TGN), plasma membrane. The precise mechanisms that connect membrane traffic TGN perinuclear compartments with motor-protein driven transport have largely remained elusive. Here we show Gadkin (also termed γ-BAR), a peripheral protein localized TGN-derived EVs, directly associates clathrin adaptor AP-1...
The rationale and study design for the multicentre, randomized, controlled CONDI2/ERIC-PPCI are discussed.
Objectives Remote ischaemic conditioning (RIC) promotes cardioprotection in patients undergoing primary percutaneous coronary intervention (pPCI) for ST-elevation myocardial infarction (STEMI). The effect of RIC may be modified by cardiovascular risk factors and their medications. We examined whether factors, lipid glucose levels, medication use influenced the efficacy with STEMI treated pPCI. Design Post hoc subgroup analysis a single-centre randomised controlled trial. Participants A total...
Patients with congestive heart failure (CHF) have impaired functional capacity and inferior quality of life. The clinical manifestations are associated structural impairments in skeletal muscle, emphasizing a need for feasible rehabilitation strategies beyond optimal anticongestive medical treatment. We investigated whether low-load blood flow restricted resistance exercise (BFRRE) or remote ischemic conditioning (RIC) could improve life patients CHF stimulate muscle myofibrillar...
Synaptic vesicles (SVs) in the central nervous system upon stimulation undergo rapid calcium-triggered exoendocytic cycling within nerve terminal that at least part depends on components of clathrin- and dynamin-dependent endocytosis machinery. How exocytic SV fusion endocytic retrieval are temporally spatially coordinated is still an open question. One possibility specialized membrane microdomains characterized by their high content cholesterol may assist spatial coordination synaptic...
Abstract Background and Aims Patients with congenital heart disease (CHD) form a high-risk subgroup for infective endocarditis (IE), necessitating tailored prevention treatment strategies. However, comprehensive nationwide data comparing IE characteristics outcomes in patients without CHD, including children, are sparse. This study aims to address this gap knowledge. Methods Using Danish registries, all from 1977 2021 were identified stratified on whether they had diagnosis of regardless its...