A5001736408- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Computational Drug Discovery Methods
- Neuropeptides and Animal Physiology
- Neurogenesis and neuroplasticity mechanisms
- Seaweed-derived Bioactive Compounds
- Receptor Mechanisms and Signaling
- Phosphodiesterase function and regulation
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Biochemical effects in animals
- Peroxisome Proliferator-Activated Receptors
- Adenosine and Purinergic Signaling
- Autophagy in Disease and Therapy
- Intensive Care Unit Cognitive Disorders
- Prenatal Substance Exposure Effects
- Effects and risks of endocrine disrupting chemicals
- Estrogen and related hormone effects
- Medicinal Plants and Neuroprotection
- bioluminescence and chemiluminescence research
- Autism Spectrum Disorder Research
Ningbo University
2016-2025
Shandong Academy of Sciences
2024
Qilu University of Technology
2024
Beijing Haidian Hospital
2022-2024
Peking University Shenzhen Hospital
2022
Nanjing University of Chinese Medicine
2021
Zhengzhou University of Light Industry
2020
Fudan University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2014
Trinity College Dublin
2004-2011
Non-steroidal anti-inflammatory agents (NSAIDs) are associated with a marked reduction in the risk of developing Alzheimer's disease, form dementia characterized by accumulation amyloid plaques containing amyloid-beta protein (Abeta). Studies effects NSAIDs upon inflammatory response surrounding and generation Abeta from precursor (APP) have led to two proposed mechanisms which may protect against disease: one, selective lowering Abeta42 subset NSAIDs; two, inflammation. Although disease is...
The mechanisms underlying the inhibition of long-term potentiation (LTP) induction by amyloidβ-peptide (Aβ) were investigated in medial perforant path rat and mouse dentate gyrus vitro . Evidence is presented this study that Aβ-mediated LTP involves activation microglia production reactive oxygen nitrogen species. In control slices, Aβ strongly inhibited NMDA receptor-dependent (NMDAR-dependent) LTP, although not NMDAR-independent or depression (LTD). NMDAR-dependent was prevented...
Fucoxanthin, a natural carotenoid abundant in edible brown seaweeds, has been shown to possess anti-cancer, anti-oxidant, anti-obesity and anti-diabetic effects. In this study, we report for the first time that fucoxanthin effectively protects against scopolamine-induced cognitive impairments mice. addition, significantly reversed increase of acetylcholinesterase (AChE) activity decreased both choline acetyltransferase brain-derived neurotrophic factor (BDNF) expression. Using an vitro AChE...
β-Amyloid (Aβ) can form aggregates through self-assembly and produce neurotoxicity in the early stage of Alzheimer's disease (AD). Therefore, inhibition Aβ assembly is considered as primary target for AD therapy. In this study, we reported that fucoxanthin, a marine carotenoid, potently reduced formation fibrils oligomers. Moreover, fucoxanthin-triggered modification significantly oligomers vitro. Molecular dynamics simulation analysis further revealed hydrophobic interaction between...
Alzheimer's disease (AD) is a complex neurodegenerative disorder with largely unexplored epigenetic landscape. This study employs an innovative approach that integrates multi-omics analysis and explainable machine learning to explore the regulatory mechanisms underlying signature of PRRT1 implicated in AD. Through comprehensive DNA methylation transcriptomic profiling, we identified distinct signatures associated gene expression AD patient samples compared healthy controls. Utilizing...
Background Abnormal lipid metabolism has been identified as a potential pathogenic mechanism of Alzheimer's disease (AD), which might be epigenetically regulated. Lysosomes are critical organelles for metabolism. However, the epigenetic modifications lysosome and regulating genes remain unclear in AD patients. Objective Explore role abnormal modifications, especially methylation metabolism-related AD. Methods Methylation beadchip MALDI-TOF mass spectrometry were used to detect genome-wide...
Abstract A number of recent studies have shown that β‐amyloid (Aβ) inhibits the induction long‐term potentiation (LTP) in hippocampus. However, little is known about mechanisms underlying such inhibition LTP. In present study, we evidence cytokine tumor necrosis factor (TNF) α has a key role Aβ The suppression LTP by was absent mutant mice null for TNF receptor type 1 (TNF‐R1) and prevented inhibitors TNFα, infliximab peptide antagonist, inhibitor TNFα production, thalidomide. addition,...
Brain derived neurotrophic factor (BDNF) has been known to play an important role in various mental disorders or diseases such as Alzheimer's disease (AD). The aim of our study was assess whether BDNF promoter methylation peripheral blood able predict the risk AD. A total 44 AD patients and 62 age- gender-matched controls were recruited current case-control study. Using bisulphite pyrosequencing technology, we evaluated four CpG sites BDNF. Our results showed that significantly higher cases...
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by neurofibrillary tangles, synaptic impairments, and loss of neurons. Oligomers β-amyloid (Aβ) are widely accepted as main neurotoxins to induce oxidative stress neuronal in AD. In this study, we discovered that fucoxanthin, a marine carotenoid with antioxidative properties, concentration dependently prevented Aβ oligomer-induced increase apoptosis intracellular reactive oxygen species SH-SY5Y cells....
Abstract Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Accumulated damaged mitochondria, which are associated with impaired mitophagy, contribute to neurodegeneration in AD. We show levels Disrupted‐in‐schizophrenia‐1 (DISC1), genetically psychiatric disorders and AD, decrease the brains AD patients transgenic model mice Aβ‐treated cultured cells. contains a canonical LC3‐interacting region (LIR) motif ( 210 FSFI 213 ), through DISC1 directly binds LC3‐I/II....
Background: As a natural carotenoid abundant in chloroplasts of edible brown algae, fucoxanthin possesses various health benefits, including anti-oxidative activity particular. Objective: In the present study, we studied whether protected against hydrogen peroxide (H2O2)-induced neuronal apoptosis. Design: The neuroprotective effects on H2O2-induced toxicity were both SH-SY5Y cells and primary cerebellar granule neurons. Results: Fucoxanthin significantly apoptosis intracellular reactive...
Background:VGF (nonacryonimic) and phosphatidylinositol 3-kinase (PI3K)/AKT (also known as protein kinase B, PKB)/mammalian target of rapamycin (mTOR) signaling play pivotal roles in depression. However, whether 3-kinase/AKT/mTOR signaling-mediated VGF participates rapid-acting antidepressant-like actions GLYX-13 is unclear.
Alpinia oxyphylla Miq. (i.e., A. oxyphylla), a traditional Chinese medicine, can exert neuroprotective effects in ameliorating mild cognitive impairment and improving the pathological hallmarks of Alzheimer's disease (AD). Here, 50 active compounds 164 putative targets were collected identified with 251 clinically tested AD-associated target proteins using network pharmacology approaches. Based on Gene Ontology/Kyoto Encyclopedia Genes Genomes pathway enrichments,...
Alzheimer's disease is a progressive neurodegenerative disorder that mainly affects the elderly. Soluble β-amyloid oligomer, which can induce neurotoxicity, generally regarded as main neurotoxin in disease. Here we report eckmaxol, phlorotannin extracted from brown alga Ecklonia maxima, could produce neuroprotective effects SH-SY5Y cells. Eckmaxol effectively prevented but did not rescue oligomer-induced neuronal apoptosis and increase of intracellular reactive oxygen species. also...
Sunitinib, a tyrosine kinase inhibitor, is clinically used for the treatment of cancer. In this study, we found first time that sunitinib inhibits acetylcholinesterase (AChE) at submicromolar concentrations in vitro. addition, dramatically decreased hippocampal and cortical activity AChE time-dependent manner mice. Molecular docking analysis further demonstrates might interact with both catalytic anion peripheral anionic sites within AChE, which accordance enzymatic results showing mixed...
Peripheral inflammatory responses affect central nervous system (CNS) function, manifesting in symptoms of memory deficits, depression, and anxiety. Previous studies have revealed that neuropeptide VGF (nonacronymic) C-terminal peptide TLQP-62 rapidly reinforces brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB) signaling, regulating consolidation antidepressant-like action. However, whether it is beneficial for lipopolysaccharide (LPS)-induced neuropsychiatric...